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Antibacterial anti-inflammatory and biomedical dressing for promoting wound healing and preparation method of dressing

A wound healing and biomedical technology, applied in the field of medical supplies, can solve the problems of ineffective prevention of wound infection, poor binding fastness of antibacterial agents, and slow wound healing speed, so as to block the penetration of bacteria and viruses, promote wound healing, The effect of avoiding secondary trauma

Inactive Publication Date: 2020-06-09
XI'AN POLYTECHNIC UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite non-woven fabric is composed of three layers of materials. The surface layer is a water-absorbing layer made of water-absorbing non-woven fabric, the middle layer is a waterproof layer made of polyethylene, polyurethane film or waterproof and breathable film, and the inner layer is made of antibacterial non-woven fabric. Antibacterial layer The medical dressings prepared on the market currently have poor antibacterial agent binding fastness, single function, unsustainable antibacterial effect, poor biocompatibility, cannot effectively prevent wound infection, slow wound healing, and poor pain relief effect Good, or some antibacterial agents have potential cytotoxicity, complex preparation process and other issues, which have great limitations in application

Method used

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  • Antibacterial anti-inflammatory and biomedical dressing for promoting wound healing and preparation method of dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Weigh 10 g of sodium alginate with a molecular weight of 80,000 and add it to 400 mL of deionized water, stir and dissolve to obtain a sodium alginate solution with a mass concentration of 2.5%; add 0.3 g of curcumin extract to the sodium alginate solution, stir After uniformity, the spinning dope is left to defoam. The prepared spinning solution is added to the coagulation bath and drawing bath of 2% and 5% calcium chloride by mass percentage respectively, and then conventional wet spinning is carried out at a temperature of 20°C, and the resulting as-spun fibers are 1.5 times The post-drawing process is followed by water washing at 20°C and heat treatment at 40°C to obtain drug-containing antibacterial and anti-inflammatory calcium alginate fibers. Send the prepared fibers into the opening machine, the opening time is 3min, and feed the carding machine through the cotton feeding system to be carded into a fiber web. The main cylinder speed of the carding machine is co...

Embodiment 2

[0040] Weigh 10 g of sodium alginate with a molecular weight of 100,000 and add it to 323 mL of deionized water, stir and dissolve to obtain a sodium alginate solution with a mass concentration of 3%; add 0.4 g of curcumin extract to the sodium alginate solution, stir After uniformity, the spinning dope is left to defoam. The prepared spinning solution is added to the coagulation bath and drawing bath of 2% and 5% calcium chloride by mass percentage respectively, and then conventional wet spinning is carried out at a temperature of 40°C, and the resulting as-spun fibers are 1.7 times The post-drawing process is followed by water washing at 40°C and heat treatment at 60°C to obtain drug-containing antibacterial and anti-inflammatory calcium alginate fibers. Send the prepared fibers into the opening machine, the opening time is 4min, and feed the carding machine through the cotton feeding system to be carded into a fiber web. The main cylinder speed of the carding machine is con...

Embodiment 3

[0044] Weigh 10 g of sodium alginate with a molecular weight of 120,000 and add it to 286 mL of deionized water, stir and dissolve to obtain a sodium alginate solution with a mass concentration of 3.5%; add 0.5 g of curcumin extract to the sodium alginate solution, stir After uniformity, the spinning dope is left to defoam. The prepared spinning solution is added to the coagulation bath and drawing bath of 2% and 5% calcium chloride by mass percentage respectively, and then conventional wet spinning is carried out at a temperature of 55°C, and the resulting as-spun fibers are 2 times The post-drawing process is followed by water washing at 55°C and heat treatment at 80°C to obtain drug-containing antibacterial and anti-inflammatory calcium alginate fibers. Send the prepared fibers into the opening machine, the opening time is 5min, and feed the carding machine through the cotton feeding system to be carded into a fiber web. The main cylinder speed of the carding machine is con...

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Abstract

The invention discloses an antibacterial anti-inflammatory and biomedical dressing for promoting wound healing and a preparation method of the dressing, and belongs to the technical field of medical supplies. The dressing uses a curcumin-containing calcium alginate fiber nonwoven fabric as a skin close layer, the curcumin-containing calcium alginate fiber nonwoven fabric can provide an ideal antibacterial environment for wound healing, promote wound healing, and relieve wound pain; the dressing uses a chitosan fiber non-woven fabric as a middle layer, and the chitosan fiber non-woven fabric has the effects of diminishing inflammation, promoting blood coagulation and inhibiting scars while absorbing exudates; the dressing uses a polyurethane film as an isolation layer, and the polyurethanefilm can achieve the effects of preventing dust, water, air leakage and pollution; and the biomedical dressing prepared by compounding the curcumin-containing calcium alginate fiber nonwoven fabric, the chitosan fiber non-woven fabric and the polyurethane film has complementary and synergistic effects, and the advantages of realizing antibacterial and bacteriostatic properties, a good anti-inflammatory effect and anti-adhesion performance, promoting rapid wound healing and having good biocompatibility. The medical hemostatic dressing provided by the invention has no side effects on human bodies and no any irritation to skin, is safe to use, environmentally friendly and pollution-free, and has wide application prospects in the field of biomedical materials.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to a biomedical dressing for antibacterial, anti-inflammatory and wound healing promotion and a preparation method thereof. Background technique [0002] Traditional medical dressings are made of natural plant fibers or animal hairs, such as gauze, wool, cotton pads, oil gauze, etc. This type of dressing is easy to stick to the wound when it is changed, and it is easy to damage the new granulation tissue when the dressing is removed, causing pain to the user and not conducive to wound healing. [0003] In order to obtain better antibacterial performance and use effect, medical dressings adopt different methods. In patent 201310165016.3, Li Li et al. added sodium alginate to nano-silver sol and mixed it with the prepared polymer cross-linking agent to provide a preparation method of sodium alginate-based antibacterial medical dressing containing nano-silver. Pa...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/20A61L15/18A61L15/26A61L15/42A61L15/44A61L15/46A61L15/50
CPCA61L15/18A61L15/20A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L15/50A61L2300/216A61L2300/232A61L2300/236A61L2300/404A61L2300/41A61L2300/412C08L5/04C08L5/08C08L75/04
Inventor 魏亮宋丹青孙润军张昭环张一心刘呈坤董洁王秋实
Owner XI'AN POLYTECHNIC UNIVERSITY
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