Bone-mimetic composite scaffold and preparation method thereof

Abstract

The invention provides a bone-imitative composite material scaffold and a preparation method thereof. The natural wood is de-lignified, and then compounded with hydroxyapatite to obtain an osteoinductive scaffold material, and the extracellular The matrix is ​​simulated to obtain the bone-mimetic composite scaffold. The invention obtains a highly anisotropic porous scaffold, and the three-dimensional pore structure provides channels for the transport of nutrients and intracellular growth and regeneration, overcomes the shortcomings of traditional isotropic scaffold materials and meets the strength and stability requirements of bone tissue regeneration. The method does not need to use special reagents and equipment, the operation is not difficult, the process conditions are mild, and it has the characteristics of easy production and popularization and application.

Description

technical field [0001] The invention belongs to the field of composite materials, and in particular relates to a bone-like composite material bracket and a preparation method thereof. Background technique [0002] Bio-scaffold materials are directly applied inside the human body and facing the complex and sensitive system of the human body, people have various and extremely high requirements for bio-scaffold materials. Therefore, the bioscaffold material must have the following characteristics: (1) good biocompatibility, it cannot have immunogenicity or cytotoxicity and cause unresolved inflammatory reactions; (2) certain mechanical strength and mechanical properties, in the operation It will not collapse during operation and normal patient activities; (3) easy to sterilize to prevent bacterial infection; (4) facilitate cell adhesion and proliferation; (5) controllable interconnected pores to guide cells to grow into the desired physical Forms and promotes vascularization o...

AI Technical Summary

Problems solved by technology

[0004] Specifically, natural polymer materials such as collagen, fibrin, and chitosan have good biocompatibility and can provide a natural three-dimensional porous structure for cell adhesion, proliferation, and differentiation, but they have poor mechanical properties, which are comparable to human bone modulus. The difference is large, and further modification and enhancement are needed

Synthetic polymers such as polyglycolic acid (PGA), polylactic acid (PLA) and polycaprolactone (PCL) are easy to process and have excellent biocompatibility and degradability, but there are also some disadvantages: hydrophilicity Poor, insufficient mechanical strength, degraded products have certain influence

However, calcium-phosphorus ceramics and bioactive glass have high mechanical strength and good biocompatibility, but they are easy to break or cannot be completely degraded, and have their own shortcomings.

Due to the problems of poor mechanical strength or weak osteogenic performance of a single material, it is difficult to meet the high requirements of bone tissue engineering scaffold materials by using the above materials alone

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