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A clinically shapeable magnesium silicate/polyamino acid composite material and its use in preparing bone repair materials

A polyamino acid and composite material technology, applied in the direction of magnesium silicate, silicate, prosthesis, etc., can solve the problems of poor osteogenesis, inability to effectively promote osteoblast proliferation, and lack of biological activity, so as to promote bone marrow Proliferation of mesenchymal stem cells, convenient clinical shaping, and good biological activity

Active Publication Date: 2021-09-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been a few reports on polymer materials used as bone repair materials in recent years, most of them lack biological activity, cannot effectively promote the proliferation of osteoblasts, and have poor osteogenesis.

Method used

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  • A clinically shapeable magnesium silicate/polyamino acid composite material and its use in preparing bone repair materials
  • A clinically shapeable magnesium silicate/polyamino acid composite material and its use in preparing bone repair materials
  • A clinically shapeable magnesium silicate/polyamino acid composite material and its use in preparing bone repair materials

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation of embodiment 1 amino acid copolymer

[0052] Weigh 95g of 6-aminocaproic acid, 24g of 4-aminobutyric acid, 5g of proline, and 3g of lysine, put them into a 250ml three-neck flask, add 60mL of deionized water at the same time, and add 0.1mL of catalyst phosphoric acid, oil Heat the bath and keep stirring to 160°C for 1 hour of dehydration, raise the temperature to 200°C for 1 hour, and continue to raise the temperature to 210°C for 3 hours. In order to avoid oxidation, nitrogen protection was used throughout the experiment, and the resulting product was amino acid copolymer, named PAA.

Embodiment 2

[0053] The preparation of embodiment 2 amino acid copolymers

[0054] Weigh 95g of 6-aminocaproic acid, 24g of 4-aminobutyric acid, 5g of proline, and 3g of lysine, put them into a 250ml three-neck flask, add 60mL of deionized water at the same time, and add 0.1mL of catalyst phosphoric acid, oil Heat the bath and keep stirring to dehydrate at 160°C for 1 hour, raise the temperature to 200°C for 1 hour, and continue to raise the temperature to 220°C for 4 hours. In order to avoid oxidation, nitrogen protection was used throughout the experiment, and the resulting product was amino acid copolymer.

Embodiment 3

[0055] Embodiment 3 Preparation of amino acid copolymer

[0056] Weigh 94g of 6-aminocaproic acid, 24g of 4-aminobutyric acid, 5g of proline, 3g of lysine, and 1.5g of glutamic acid, put them into a 250ml three-necked flask, add 60mL of deionized water at the same time, and add Catalyst Phosphoric acid 0.1mL, heated in an oil bath and continued to stir to dehydrate at 160°C for 1h, raise the temperature to 200°C for 1h, and continue to raise the temperature to 220°C for 3h. In order to avoid oxidation, nitrogen protection was used throughout the experiment, and the resulting product was amino acid copolymer.

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Abstract

The invention provides a clinically shapeable magnesium silicate / polyamino acid composite material and its application in preparing bone repair materials. The composite material is made of clinically shapeable polyamino acid and magnesium silicate as raw materials. obtained; the clinically sculptable polyamino acid is polymerized as a monomer by any 3 or 4 amino acids in 6-aminocaproic acid and 4-aminobutyric acid, proline, lysine, and glutamic acid owned. In the composite material of the present invention, the base material is a polyamino acid that can be molded by hot water, and its glass transition temperature is 44-55°C, which can be arbitrarily shaped at a relatively low temperature, which is beneficial to doctors during the operation according to the shape of the bone. The specific shape of the defect is manipulated. The composite material of the present invention has good biological activity, is beneficial to bone formation in vivo, and can effectively promote the proliferation of bone marrow mesenchymal stem cells, and has good application prospects in the preparation of bone repair materials for repairing irregular bone defects and promoting regeneration of bone defects .

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a clinically plastic magnesium silicate / polyamino acid composite material, a preparation method thereof, and an application in preparing bone defect repair materials. Background technique [0002] Bone injury repair has always been one of the common problems in orthopedics. Every year in my country, more than 50 million people suffer from bone injuries or bone defects caused by trauma, tumors, congenital diseases and other reasons. For large areas of damage, bone tissue is difficult to repair itself, and bone substitute materials are needed for filling and repairing. Therefore, the research and development of new bone defect repair materials is of great clinical significance. [0003] The shape of human bone defects is often irregular, such as skull, jaw, vertebrae and other defects such as limb bones, etc., which requires bone repair materials to have the charac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44A61L27/56C01B33/22C08G69/04C08G69/08
CPCA61L27/446A61L27/56A61L2430/02C01B33/22C08G69/04C08G69/08C08L77/04
Inventor 李鸿魏杰李漱阳何浩生李林郑衡彭海涛杜艳杨爱萍吕国玉
Owner SICHUAN UNIV
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