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Novel application of cortex magnoliae officinalis glycoside ingredient in improvement of gastrointestinal function

A technology of glycosides and Magnolia, applied in the field of medicine and health

Active Publication Date: 2020-07-17
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report that glycosides in Magnolia officinalis are used to improve gastrointestinal function

Method used

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  • Novel application of cortex magnoliae officinalis glycoside ingredient in improvement of gastrointestinal function
  • Novel application of cortex magnoliae officinalis glycoside ingredient in improvement of gastrointestinal function
  • Novel application of cortex magnoliae officinalis glycoside ingredient in improvement of gastrointestinal function

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The extraction and separation of total glucosides of Magnolia officinalis, as described in Xue Zhenzhen's article (Phytochemistry, 2016, 127:50-62. DOI: 10.1016 / j.phytochem.2016.03.011).

[0033] (1) Magnolia officinalis dried bark 40kg, pulverized, heated and refluxed with 40L of 70% ethanol water and extracted 3 times.

[0034] (2) Concentrate the extract obtained from (1) ethanol-water extraction, and then extract three times with 30 L of ethyl acetate.

[0035] (3) The aqueous solution extracted in (2) was passed through a D101 macroporous resin column, eluted with 5 times column volume of distilled water to remove impurities, and then eluted with 5 times column volume of 20% ethanol water.

[0036] (4) Concentrate the 20% ethanol water eluate in (3) to dryness to obtain the total glycosides of magnolosides.

[0037] (5) Separating and purifying the total glycosides in (4), using 1 H NMR, 13 C NMR and mass spectrometry were used to identify 11 new phenylethanol g...

Embodiment 2

[0039] In order to evaluate the new application of magnolosides of the present invention, rats modeled with iodoacetamide (IAA) combined with eating every other day were selected for effect evaluation. 40 SPF-grade healthy male 7-day-old SD mice were provided by the Experimental Animal Center of the Academy of Military Medical Sciences, license number SCXK (Army) 2012-0004. With the approval of the Experimental Animal Welfare Committee, the animals were kept in the animal room of the Institute of Basic Theory, China Academy of Chinese Medical Sciences. water. All animals were adaptively fed for 3 days before the start of the experiment. Rats in the normal group were given 0.2 mL of 2% sucrose solution orally, once a day, and continued to build the model for 6 days; rats in the model group were given 0.2 mL of 0.1% IAA and 2% sucrose mixture, once a day, Continue modeling for 6 days. The young mice were weaned at the age of 3 weeks, and were fed normally until the age of 6 w...

Embodiment 3

[0045] Functional dyspepsia model rats were selected to study motilin, the target of magnolosides, as follows.

[0046] In order to evaluate the target of magnolosides of the present invention, rats modeled with iodoacetamide (IAA) combined with feeding every other day were selected for effect evaluation. 40 SPF-grade healthy male 7-day-old SD mice were provided by the Experimental Animal Center of the Academy of Military Medical Sciences, license number SCXK (Army) 2012-0004. With the approval of the Experimental Animal Welfare Committee, the animals were kept in the animal room of the Institute of Basic Theory, China Academy of Chinese Medical Sciences. water. All animals were adaptively fed for 3 days before the start of the experiment. Rats in the normal group were given 0.2 mL of 2% sucrose solution orally, once a day, and continued to build the model for 6 days; rats in the model group were given 0.2 mL of 0.1% IAA and 2% sucrose mixture, once a day, Continue modeling...

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Abstract

The invention relates to the fields of medicine and health, and discloses a novel application based on cortex magnoliae officinalis glycoside ingredient total glycoside, and the cortex magnoliae officinalis glycoside ingredient total glycoside is used to prepare products for improving a gastrointestinal function. Specifically, the inventors extract and separate the cortex magnoliae officinalis glycoside ingredient total glycoside through a natural medicinal chemistry method, and find that the cortex magnoliae officinalis glycoside ingredient total glycoside has the ability of regulating multiple gastrointestinal function-related indicators through pharmacological research, and the cortex magnoliae officinalis glycoside ingredient total glycoside has the ability of increasing the content ofmotilin and gastrin in serum and reducing the content of nitric oxide synthase, calcitonin gene-related peptide and vasoactive intestinal peptide in the serum, and 5-hydroxytryptamine in colon tissue, and can regulate the intestinal flora structure and reduce the content of short-chain fatty acids, so that the cortex magnoliae officinalis glycoside ingredient total glycoside has a good effect ofregulating the gastrointestinal function, and can be applied to the preparation and development of the products for improving the gastrointestinal function.

Description

technical field [0001] The invention relates to a new application of glycoside components extracted and separated from the traditional Chinese medicine Magnolia officinalis for improving gastrointestinal function, and belongs to the field of medicine and health. Background technique [0002] In recent years, with the increase of work pressure and the change of lifestyle, the occurrence of human gastrointestinal diseases is also increasing, and at the same time, other organs are also involved in lesions. Among them, functional dyspepsia (Functional Dyspepsia, FD) is a disease that seriously affects the daily activities of patients, manifested as one or more of the following symptoms: postprandial satiety, early satiety, epigastric pain, and epigastric burning sensation. In addition, this disease is a typical physical and mental disease, and the quality of life of FD patients will decline, and the mood will be depressed, such as anxiety and depression, which are common clinica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/575A61P1/14A61K129/00
CPCA61K36/575A61P1/14
Inventor 杨滨卫军营吴长勋薛珍珍
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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