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Method for separating plurality of active ingredients from peanut coat

A technology of active ingredients and peanut shells, which is applied in the field of separation of active ingredients of peanut shells, can solve the problems of excessive aflatoxin and other problems, and achieve the effects of low production cost, high yield and strong operability

Active Publication Date: 2020-07-28
HUNAN HUACHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In addition, in the existing peanut shell extracts on the market, a serious quality problem - aflatoxin exceeding the standard - has not been properly resolved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] (1) Extraction and separation of higher fatty acids: take 1 kg of raw material of peanut shell, crush it to 20 mesh, add organic solvent to heat and reflux to extract twice, the first extraction is to use 10L of petroleum ether and ethyl acetate according to the volume ratio of 4:1 The mixed solvent, the extraction time is 2 hours; the second extraction is to use 7L of 6# solvent oil and 120# solvent oil according to the volume ratio of 1:1 mixed solvent, the extraction time is 1 hour, filter, and combine the two organic solvent extracts , the extraction residue is stand-by; the combined extract is passed through a silica gel chromatography column at a flow rate of 0.5BV / hour (the amount of silica gel used in column chromatography is 0.2L, and the height-to-diameter ratio of the silica gel chromatography column is 5:1), and the silica gel is collected The effluent from the chromatography column was concentrated until there was no solvent to obtain 99.17 g of a light yell...

Embodiment 2

[0046] (1) Extraction and separation of higher fatty acids: take 1 kg of peanut shell raw material, crush it to 20 mesh, add organic solvent to heat and reflux for extraction twice (the first extraction is 9L of petroleum ether and ethyl acetate according to the volume ratio of 6:1) Mixed solvent, the extraction time is 3 hours; the second time 6L of 6# solvent oil and 120# solvent oil are mixed solvents according to the volume ratio of 3:1, the extraction time is 1 hour), filter, and obtain the extraction residue for use. Combine two organic solvent extracts, the extract is passed through a silica gel chromatography column at a flow rate of 0.8BV / hour (the amount of silica gel used in column chromatography is 0.16L, and the height-to-diameter ratio of the silica gel chromatography column is 7:1), and the silica gel is collected. The effluent from the chromatography column was concentrated until there was no solvent to obtain 94.72 g of a light yellow oily substance, which is h...

Embodiment 3

[0053] (1) Extraction and separation of higher fatty acids: Take 1 kg of raw peanut shells, crush them to 20 meshes, add organic solvent to heat and reflux for extraction twice, the first extraction is a mixture of 8L petroleum ether and ethyl acetate at a volume ratio of 5:1 Solvent, the extraction time is 3 hours; the second time 8L of 6# solvent oil and 120# solvent oil are mixed solvents according to the volume ratio of 1:3, the extraction time is 2 hours, filter, and extract the residue for use. Combine two organic solvent extracts, pass the extract through a silica gel chromatography column at a flow rate of 0.6BV / hour (the amount of silica gel used in column chromatography is 0.12L, and the height-to-diameter ratio of the silica gel chromatography column is 8:1), and the silica gel is collected. The effluent from the chromatography column was concentrated until there was no solvent to obtain 95.19 g of a light yellow oily substance, which is higher fatty acid of peanut s...

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Abstract

The invention provides a method for separating multiple active ingredients from peanut coat. The method comprises the following steps: carrying out heating reflux extraction on a peanut coat raw material by adopting a lipophilic organic solvent for more than two times to extract higher fatty acid, carrying out hot water extraction on extraction residues again, carrying out ultrafiltration and nanofiltration, treating a nanofiltration membrane trapped fluid to obtain peanut coat procyanidine, adsorbing a nanofiltration membrane permeate liquid by using a polyamide resin column, eluting to obtain peanut coat catechin, adding low-carbon alcohol into the hot water extraction residues, and obtaining the peanut coat resveratrol through a chromatography aluminum oxide resin column. According to the method, various peanut coat active ingredients can be simply and continuously extracted, peanut coat resources can be comprehensively utilized, the process is coherent and simple, the content of various active ingredients is high, the yield is high, aflatoxin is not contained, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for separating active components from peanut shells, in particular to a method for separating multiple active components from peanut shells. Background technique [0002] The peanut coat is the seed coat of Arachis hypogaea L., a plant of the genus Arachis of the leguminous family, that is, the thin purplish red skin outside the peanut. Peanuts are rich in active ingredients, and have the effects of stopping bleeding, dispelling blood stasis, and reducing swelling. They are widely used clinically. The best way to eat them is to boil them. Traditional Chinese medicine believes that peanut red coat can nourish the Qi of the spleen and stomach, and can achieve the effect of nourishing blood and stopping bleeding. Western medicine believes that peanut red coat can inhibit the dissolution of fibrin, increase the content of platelets, improve the quality of platelets, improve the defects of coagulation factors, strengthen t...

Claims

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Application Information

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IPC IPC(8): C07D311/62C07C37/82C07C37/84C07C37/70C07C39/21A61P3/06A61P7/02A61P39/06C11B1/10C11B3/10
CPCC07D311/62C07C37/685C07C37/82C07C37/84C07C37/70A61P3/06A61P7/02A61P39/06C11B1/10C11B3/10C07C39/21
Inventor 李伟黄华学
Owner HUNAN HUACHENG BIOTECH
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