Method for preparing taurine

A technology of taurine and sodium isethionate, which is applied to the preparation of sulfonic acid, chemical instruments and methods, and the preparation of organic compounds, can solve problems such as harsh reaction conditions, accumulation of by-products, and easy precipitation of salts, and achieve The effect of mild reaction temperature and pressure conditions, promotion of ammonia nucleophilic attack on hydroxyl carbon, and mild temperature and pressure conditions

Active Publication Date: 2020-08-25
WANHUA CHEM GRP CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0004] The synthetic technique of taurine is mainly divided into two classes at present: 1) ethanolamine technique, main disadvantage is that the reaction cycle is long, the yield is low, the cost is on the high side, and the generation of three wastes is relatively serious, which is now a non-mainstream production technique; 2) environmental protection Oxyethane process, which is the mainstream process for the production of taurine at present, has the advantages of low production cost, high yield of taurine, and small output of three wastes. However, the ammonolysis reaction conditions of sodium isethionate in this process Harsh, under high temperature and high pressure, salt is easy to precipitate, causing blockage of equipment and instruments, requiring regular shutdown and maintenance, affecting the increase in production capacity, increasing production costs and safety risks
In addition, by-products such as ethylene glycol, ethanolamine, and diethylene glycol are accumulated in the process of recycling the mother liquor, and the mother liquor needs to be discharged quantitatively on a regular basis, which affects the total yield of the product.
[0005] To sum up, the current taurine preparation process has harsh reaction conditions, high safety risks, and accumulation of by-products. The mother liquor containing active ingredients needs to be discharged in an appropriate amount, which reduces the total yield of the product and increases the production cost.

Method used

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  • Method for preparing taurine

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preparation example Construction

[0035] BaCaTiO 4 Catalyst preparation method: weigh nano-scale BaCO according to the molar ratio of 1:1:1 3 、TiO 2 and CaCO 3 After the particles are mixed, they are fully ground by a ball mill for 45 minutes, then transferred to a muffle furnace, calcined at 1300°C for 4.5 hours, and then rapidly cooled to room temperature to obtain the desired catalyst.

[0036] BaCe 2 Ti 5 o 15 Catalyst preparation method: weigh nano-scale BaCO in a molar ratio of 1:5:2 3 、TiO 2 and CeO 2 After the particles are mixed, they are fully ground by a ball mill for 30 minutes, then transferred to a muffle furnace, and calcined at 1250°C for 3.5 hours, then heated up to 1300°C, continued to be calcined for 4 hours, and the desired catalyst can be obtained after cooling down to room temperature.

[0037] BaTi 6 co 6 o 19 Catalyst preparation method: weigh nano-scale BaCO according to the molar ratio of metal atoms in the molecular formula 1:6:3 3 、TiO 2 and Co 2 o 3 After the particl...

Embodiment 1

[0039] 496g sodium isethionate aqueous solution (40wt%), 300g reuse mother liquor (the mother liquor solid after drying is diluted to 50wt% through ultrapure water) is placed in 1L high-pressure reactor, feeds a certain amount of liquid ammonia, makes liquid The ammonia concentration reaches 24wt%, the concentration of sodium isethionate in the mixed solution is 19wt%, and the ammonolysis reaction catalyst BaTi is added 6 co 6 o 19 , the consumption of catalyst is 6wt% of sodium isethionate. The temperature of the reaction system was raised to 225° C., the pressure of the system was 18 MPa, and the reaction was carried out for 40 minutes. The yield of sodium taurate obtained by the ammonolysis reaction was 94%. After the reaction solution was flashed at 184°C to remove ammonia, it was evaporated and concentrated to increase the concentration of sodium taurine to 43wt%, and then a certain amount of concentrated sulfuric acid was added at 80°C to adjust the pH of the system to...

Embodiment 2

[0041] 500g sodium isethionate solution (42wt%), 400g reuse mother liquor (the mother liquor solid after drying is diluted to 55wt% through ultrapure water) is placed in 1L high-pressure reactor, feeds a certain amount of liquid ammonia, makes liquid The ammonia concentration reaches 21wt%, the concentration of sodium isethionate in the mixed solution is 18.4wt%, and the ammonolysis reaction catalyst BaCaTiO is added 4 , the consumption of catalyst is 5.5wt% of sodium isethionate. The temperature of the reaction system was raised to 230° C., the pressure of the system was 18 MPa, and the reaction was carried out for 40 minutes. The yield of sodium taurate obtained in this step was 92%. After the reaction solution was flashed at 180°C to remove ammonia, it was evaporated and concentrated to increase the concentration of sodium taurine to 40wt%, and then a certain amount of concentrated sulfuric acid was added at 60°C to adjust the pH of the system to 8.2, and then cooled to 30°...

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Abstract

The invention provides a method for preparing taurine. An adopted heterogeneous catalyst system can greatly improve the technological conditions for preparing taurine from sodium isethionate, and in addition, byproducts including ethanolamine, ethylene glycol and dipolyethylene glycol are removed through a high-temperature spray dryer, and complete application of effective components of mother liquor is achieved. Compared with the traditional process, the process has the advantages that the reaction temperature and pressure conditions required by the ammonolysis reaction of the sodium isethionate are milder, and meanwhile, the reaction time is also shortened. The method realizes complete application of effective components in the mother liquor, significantly improves the total yield of taurine, is easy for industrial production, and reduces the production cost of the product.

Description

technical field [0001] The invention relates to a method for preparing taurine. Background technique [0002] Taurine, also known as taurocholic acid, taurobilin, and chemical name 2-aminoethanesulfonic acid, is an essential non-protein amino acid that exists in almost all organs of humans and mammals in free form. The role of taurine is different from that of other amino acids. It can promote the growth and development of the nervous system, protect the brain, improve memory, and improve optic nerve conduction and visual function. It can also protect the heart, prevent and treat cardiovascular and cerebrovascular diseases and other important diseases. Features. Taurine has high medicinal value and is an important nutrient. It is widely used in functional beverages, pet food, health food, feed, medicine and other fields. It can also be used as biochemical reagents and other organic synthesis intermediates. A fine chemical with wide application value. [0003] [0004] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C303/22C07C303/44C07C309/14B01J23/02B01J23/10B01J23/78
CPCC07C303/22C07C303/44B01J23/002B01J23/10B01J23/78B01J23/02B01J2523/00C07C309/14B01J2523/25B01J2523/3712B01J2523/47B01J2523/23B01J2523/845
Inventor 张静桂振友郭斌蔺海政钟子太孔令晓梁静王文李晶陈来中张永振
Owner WANHUA CHEM GRP CO LTD
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