Carboxylic acid derivatization reagent as well as preparation method and application thereof

A technology for derivatizing reagents and carboxylic acids, applied in the field of analytical chemistry, can solve the problems of insufficient sensitivity, complicated derivatization operations, and the influence of strong ionization efficiency of derivatization reagents, and achieves high reactivity, mild derivatization conditions, and properties. stable effect
CN111574476AActive Publication Date: 2020-08-25SHANDONG ANALYSIS & TEST CENT

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG ANALYSIS & TEST CENT
Publication Date
2020-08-25

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Abstract

The invention provides a carboxylic acid derivatization reagent as well as a preparation method and application thereof, and belongs to the technical field of analytical chemistry. The carboxylic acidderivatization reagent is specifically ammonium N,N,N-trimethyl-2-(piperazine-1-yl)ethane-1-iodide, and the structural formula of the carboxylic acid derivatization reagent is shown in the specification. The carboxylic acid derivatization reagent can be used as a derivatization reagent for carboxylic acid metabolite spectrum detection, and has a good mass spectrum sensitization effect, so that the carboxylic acid derivatization reagent has good practical popularization and application values.
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Description

Technical field

[0001] The invention relates to the technical field of analytical chemistry, in particular to a carboxylic acid derivatization reagent and a preparation method and application thereof. Background technique

[0002] Disclosure of the background information is only intended to increase the understanding of the overall background of the present invention, and is not necessarily regarded as an acknowledgement or in any form suggesting that the information constitutes the prior art known to those of ordinary skill in the art.

[0003] Carboxylic acid compounds such as fatty acid, bile acid, malic acid, citric acid, succinic acid, indole acetic acid, abscisic acid, etc. are important metabolites in the organism. They play a role in cell proliferation, energy metabolism, signal transduction, etc. Crucial role. Changes in the content of these metabolites can reflect the biological state of the body. For example, the abnormal regulation of metabolites related to the tricar...

Claims

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