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High polymer material surface anticoagulation modification method

A polymer material, anti-coagulation technology, applied in the direction of heparin coatings, alginic acid coatings, coatings, etc., can solve the problems of low grafting rate of heparin sodium, limited surface amount of heparin sodium, and general anti-coagulation function effect, etc. The preparation method is simple and feasible, the anticoagulant effect is promoted, and the anticoagulant effect is prevented from being lasting.

Active Publication Date: 2020-09-08
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anticoagulant function provided by this scheme is achieved through the chemical grafting reaction between heparin sodium and the matrix material. The grafting rate of heparin sodium is generally low and the amount of heparin sodium on the surface of the material is limited, resulting in a general anticoagulant function.

Method used

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  • High polymer material surface anticoagulation modification method
  • High polymer material surface anticoagulation modification method
  • High polymer material surface anticoagulation modification method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Preparation of sodium alginate and organosilicon quaternary ammonium salt charge complex: prepare respectively a concentration of 4wt% sodium alginate aqueous solution (the number average molecular weight of sodium alginate is 80000) and a concentration of 4wt% trimethyl[3-(trimethyl Oxysilyl)propyl]ammonium chloride aqueous solution, sodium alginate and trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride are mixed at room temperature according to the mass ratio of 2:1, and an insoluble Precipitated in water, centrifuged, washed 3 times with water and dried to obtain charge complex of sodium alginate and trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride.

[0073] Soak the poly(4-methyl-1-pentene) hollow fiber membrane in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried hollow fiber membrane into the chamber of the plasma processor and fix it. Vacuum to 1Pa, pass through oxygen for surface activation. The air pressure in the cavity is 35...

Embodiment 2

[0077]Preparation of sodium alginate and organosilicon quaternary ammonium salt charge complex: prepare respectively a concentration of 1.5wt% sodium alginate aqueous solution (the number average molecular weight of sodium alginate is 10000) and a concentration of 1.5wt% dimethyltetradecane Base[3-(triethoxysilyl)propyl]ammonium chloride aqueous solution, sodium alginate and dimethyltetradecyl[3-(triethoxysilyl)propyl]ammonium chloride according to Mix at room temperature with a mass ratio of 1:1 to rapidly form a water-insoluble precipitate. After centrifugation, wash with water three times and dry to obtain sodium alginate and dimethyltetradecyl[3-(triethoxysilane base) propyl] ammonium chloride charge complex.

[0078] Soak the poly(4-methyl-1-pentene) hollow fiber membrane in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried hollow fiber membrane into the chamber of the plasma processor and fix it. Vacuum to 1Pa, pass through oxygen for surface a...

Embodiment 3

[0082] Preparation of sodium alginate and organosilicon quaternary ammonium salt charge complex: prepare respectively a concentration of 2.5wt% sodium alginate aqueous solution (the number average molecular weight of sodium alginate is 30000) and a concentration of 2.5wt% dimethyl octadecane Base[3-(trimethoxysilyl)propyl]ammonium chloride aqueous solution, sodium alginate and dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride according to mass ratio Mix at room temperature at a ratio of 1:2, rapidly form a water-insoluble precipitate, centrifuge, wash 3 times with water and dry to obtain sodium alginate and dimethyloctadecyl[3-(trimethoxysilyl)propane base] ammonium chloride charge complex.

[0083] Soak the poly(4-methyl-1-pentene) hollow fiber membrane in deionized water for 24 hours, dry it in a vacuum drying oven, put the dried hollow fiber membrane into the chamber of the plasma processor and fix it. Vacuum to 1Pa, pass through oxygen for surface activation. ...

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Abstract

The invention relates to the technical field of medical polymer materials and medical instruments, in particular to a high polymer material surface anticoagulation modification method. The high polymer material surface anticoagulation modification method comprises the following steps: A) performing low-temperature plasma activation treatment on the high polymer material; b) putting the activated high polymer material into an organic solution containing a charge compound for 0.5-10 minutes, taking out, and drying to obtain a high polymer material coated with the charge compound, wherein the charge compound is prepared from raw materials including sodium alginate and organosilicon quaternary ammonium salt; and C) placing the high polymer material coated with the charge compound in an aqueoussolution of heparin sodium for 0.5-10 min, taking out the high polymer material, and heating the high polymer material at 40-80 DEG C to obtain the high polymer material containing the anticoagulation coating. The anticoagulation coating obtained by the high polymer material surface anticoagulation modification method is not liable to fall off, and the anticoagulation effect is better.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials and medical devices, in particular to a method for modifying the anticoagulant surface of polymer materials. Background technique [0002] The surface of medical polymer materials is in direct contact with the outside, and its surface properties are crucial to subsequent applications. Therefore, effective methods are used to control and adjust the physical and chemical properties of the surface to make the material have friction, adhesion, wettability, and conductivity. , antibacterial, biocompatibility, etc. As a medical polymer material, its functionality is mainly manifested through the contact between the surface of the material and the biological environment. Therefore, it is necessary to functionally modify the surface of the medical material, otherwise bacteria will cause infection and blood coagulation will cause thrombus. For blood-contact materials, the first thing tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J7/04C09D105/04C09D7/63C09D105/10C08L23/20
CPCC08J7/042C08J7/123C08J2323/20C08J2405/04C08J2405/10C09D105/04C09D105/10C09D7/63C08K5/544
Inventor 石恒冲栾世方殷敬华杨华伟周容涛孙振龙
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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