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Magnetic renewable antibacterial agent and preparation method thereof

An antibacterial agent and magnetic technology, applied in the field of magnetic regenerable antibacterial agent and its preparation, can solve the problems of antibacterial agent loss, difficulty, easy loss, etc., and achieve the effect of solving difficult processing

Inactive Publication Date: 2020-09-15
邓天生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Fe with magnetic effect via reversible addition-fragmentation chain transfer reaction 3 o 4 Grafted onto graphene oxide-loaded block copolymers of organic antibacterial agents, it overcomes the shortcomings of uneven dispersion and easy loss of common antibacterial agents; it solves the problem of difficult disposal of antibacterial agents after loss, and at the same time, inorganic nano-particles with magnetic effects The particles are grafted onto the organic antibacterial agent, and there is no incompatibility between the two

Method used

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  • Magnetic renewable antibacterial agent and preparation method thereof
  • Magnetic renewable antibacterial agent and preparation method thereof
  • Magnetic renewable antibacterial agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of graphene oxide.

[0030] The 250mL check bottle was put into a freezing tank whose system temperature was 0°C, and 27.6mL of concentrated sulfuric acid (98wt%H 2 SO 4 ), keep the temperature below 5°C, slowly add 1.2g graphite powder while stirring, continue stirring for 1.5h, then slowly add 3.6g KMnO 4 After stirring for 10 minutes, the solution was purple-green. The reaction temperature was controlled below 20°C and the reaction was continued for 1 hour. Then, the reaction flask was placed in an oil bath at 35°C for 3 hours, and 55 mL of deionized water was added slowly, and the temperature was raised to 95°C for continuous stirring. 15min, then add 140mL of water to stop the reaction. 6mL hydrogen peroxide (30wt%H 2 o 2 ) into the reaction system, observe the color change of the solution, stop dripping hydrogen peroxide when the solution just turns yellow, pour off the supernatant, rinse twice with 2wt% HCl solution, and then wash three times with...

Embodiment 2

[0032] Fe 3 o 4 Preparation of surface reversible addition-fragmentation chain transfer agents.

[0033] Fe 3 o 4 Nanoparticles are prepared by the method of Ding, Y.L., etc. Mater.Sci.Eng.C.48,487-498 (2015), and then prepared on Fe by the method of Makhluf, S.B., etc. Small.4,1453-1458 (2008). 3 o 4 Amino groups were introduced into the surface of nanoparticles to obtain aminated Fe 3 o 4 Nanoparticles (amino group content 16.06 mmol / g). Add 4-cyano-4-(thiobenzoyl)valeric acid (0.1118g, 0.4mmol) and 1-hydroxybenzotriazole (0.0405g, 0.3mmol) into a 150mL branched-necked flask, pump nitrogen After three times, N 2 Under protection, 30 mL of dichloromethane was added with a disposable syringe, and the aminated Fe dissolved in 30 mL of dichloromethane 3 o 4 Nanoparticles (0.0125g, 0.2mmol) were added to the reaction flask, and after stirring at room temperature for 30min, 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride dissolved in 10mL of dichloromethane (0...

Embodiment 3

[0035] Fe 3 o 4 Preparation of grafted poly-4-vinylbenzaldehyde hybrids.

[0036] The synthetic Fe of above-mentioned embodiment 2 3 o 4 Surface reversible addition-fragmentation chain transfer agent (0.09g, 0.1mmol) and 4-vinylbenzaldehyde (3.83mL, 30mmol) were dissolved in 30mL dioxane, and azobisisobutyronitrile (0.0821g, 0.5 mmol) as an initiator, reacted in an oil bath at 70°C under the protection of nitrogen for 12 hours, put it in an ice-water bath to terminate the reaction, precipitated and washed the reaction product with diethyl ether, and after continuous precipitation and washing for 3 times, freeze-dried the purified product and dried it under vacuum at 35°C Dry to constant weight to obtain solid powdery Fe 3 o 4 The grafted poly-4-vinylbenzaldehyde hybrid was 3.09 g, and the yield was 76.2%.

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Abstract

The invention discloses a magnetic renewable antibacterial agent and a preparation method thereof. The Fe3O4 with a magnetic effect is grafted to the segmented copolymer of the graphene oxide loaded organic antibacterial agent through a reversible addition-fragmentation chain transfer reaction; according to the prepared magnetic renewable antibacterial agent, the defects that a common antibacterial agent is uneven in dispersion and prone to loss are overcome, the problem that treatment is difficult after the antibacterial agent is lost is solved, meanwhile, inorganic nano particles with the magnetic effect are grafted to an organic antibacterial agent, and the situation that the inorganic nano particles and the organic antibacterial agent are incompatible does not exist.

Description

technical field [0001] The invention belongs to the field of macromolecule chemical synthesis, and in particular relates to a magnetic reproducible antibacterial agent and a preparation method thereof. Background technique [0002] Organic antibacterial agents not only have a broad-spectrum and high-efficiency bactericidal ability, but also have a wide range of sources, low cost, and simple processing technology. The antibacterial mechanism of organic antibacterial agents: (1) inactivate microbial metabolic enzymes, affect the metabolism of microorganisms, and achieve the purpose of sterilization; (2) react with intracellular proteases to destroy cell functions; (3) block DNA synthesis and inhibit microbial reproduction ; (4) promote redox reaction, disrupt cell growth; (5) hinder amino acid translipid. [0003] The production of natural selenium-enriched water usually needs to go through steps such as water diversion, aeration, filtration, disinfection, and packaging. The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N55/10A01P1/00H01F1/42C08F292/00C08F212/14C08F293/00C08F8/42
CPCA01N55/00C08F8/42C08F292/00C08F293/005C08F212/24H01F1/42C08F212/22
Inventor 邓天生
Owner 邓天生