Low-molecular-weight chondroitin sulfate and preparation method thereof

A technology of chondroitin sulfate and low molecular weight, which is applied in the preparation of sugar derivatives, chemical instruments and methods, and medical preparations containing active ingredients, etc. It can solve the problems of insufficient research, narrow range of molecular weight distribution, and low catalytic efficiency. , to achieve the effects of short production cycle, narrow molecular weight distribution range and high enzyme activity
CN111741963AInactive Publication Date: 2020-10-02NANJING HANXIN PHARMA TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING HANXIN PHARMA TECH CO LTD
Publication Date
2020-10-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a low-molecular-weight chondroitin sulfate and a preparation method thereof. Macromolecular chondroitin sulfate is used as a raw material, and the low-molecular-weight chondroitin sulfate having average molecular weight of less than 1000 daltons is produced through a production process comprising chondroitin sulfate lyase degradation, deproteinization, filtration sterilization, drying, and the like. According to the low-molecular-weight chondroitin sulfate, the molecular weight distribution range is narrow, the content of chondroitin sulfate disaccharide is 43-60%, thecontent of chondroitin sulfate tetrasaccharide is 30-45%, the sum of contents of the chondroitin sulfate disaccharide and the chondroitin sulfate tetrasaccharide is greater than 87%, the total contentof oligosaccharides in the low-molecular-weight chondroitin sulfate is 97% or above, and the protein content is not more than 0.5%. Compared with common marketed macromolecular chondroitin sulfate, the product has a more obvious repairing effect on chondrocytes damaged by 1mM hydrogen peroxide at a concentration of 50-100 [mu]g / mL, has a strong repairing ability and a repair rate between 14% and23%, can be used to treat joint injuries, and is an important raw material for medical products, healthcare products, cosmetics, food, etc..
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Description

technical field

[0001] The invention belongs to the technical field of biochemical industry, and in particular relates to a low molecular weight chondroitin sulfate and a preparation method thereof. Background technique

[0002] Chondroitin sulfate (Chondroitin sulfate, CS, macromolecular chondroitin sulfate or chondroitin sulfate polysaccharide) is a kind of linear polysaccharide containing polyanions, composed of D-glucuronic acid (GlcA) and N-acetyl-D-amino semi Lactose (GalNAc) is connected by β-1,3 glycosidic bonds to form disaccharide units, and the disaccharide units are connected by β-1,4 glycosidic bonds, and sulfate groups are introduced at different positions during the subsequent biosynthesis process. Widely present in the cartilage and connective tissue of various animals.

[0003] A large number of studies have shown that CS has the activities of lowering blood fat, anti-atherosclerosis, enhancing immunity, anti-viral hepatitis and anti-tumor. field. For exa...

Claims

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