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Nano-copper and nano-zinc oxide biphasic deposition copper-zinc co-doped nano-hydroxyapatite and preparation method thereof

A technology of nano-hydroxyapatite and nano-zinc oxide, which is applied in chemical instruments and methods, botanical equipment and methods, nanotechnology, etc., can solve the problem that nano-hydroxyapatite has no antibacterial ability, and the antibacterial effect is limited by concentration, etc. Problems, to achieve the effect of prolonging the release time, improving biological activity, and strengthening antibacterial ability

Inactive Publication Date: 2020-10-23
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the test and characterization, the antibacterial activity of the material is long-lasting and the effect is obvious, which can effectively solve the shortcomings and defects of nano-hydroxyapatite without antibacterial ability and the antibacterial effect is limited by the concentration.

Method used

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  • Nano-copper and nano-zinc oxide biphasic deposition copper-zinc co-doped nano-hydroxyapatite and preparation method thereof
  • Nano-copper and nano-zinc oxide biphasic deposition copper-zinc co-doped nano-hydroxyapatite and preparation method thereof

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Effect test

Embodiment 1

[0026] A preparation method of nano-copper and nano-zinc oxide dual-phase deposition of copper-zinc co-doped nano-hydroxyapatite, the steps are as follows:

[0027] (1) Copper and zinc ion doping: Under rapid stirring conditions, the phosphoric acid mixed solution containing copper sulfate and zinc nitrate is added dropwise to the calcium hydroxide suspension for reaction within 40-60 minutes, and the reaction is carried out after 6 hours by centrifugation , Ball milling for 3 hours, aging for 12 hours, washing, drying at 80°C for 12 hours, and calcining at 750°C for 8 hours to prepare copper-zinc co-doped nano-hydroxyapatite powder.

[0028] Among them, the molar ratio of the sum of copper atoms in copper sulfate, zinc atoms in zinc nitrate, and calcium atoms in calcium hydroxide to phosphorus atoms in phosphoric acid is 1.67:1. The molar ratio of copper atoms in copper sulfate to zinc atoms in zinc nitrate is 1:1, and the amounts of the two substances each account for copper atom...

Embodiment 2

[0035] A preparation method of nano-copper and nano-zinc oxide dual-phase deposition of copper-zinc co-doped nano-hydroxyapatite, the steps are as follows:

[0036] (1) Copper and zinc ion doping: Under rapid stirring conditions, the phosphoric acid mixed solution containing copper sulfate and zinc nitrate is added dropwise to the calcium hydroxide suspension for reaction within 40-60 minutes, and the reaction is conducted for 6 hours after centrifugation , Ball milling for 3 hours, aging for 12 hours, washing, drying at 80°C for 12 hours, and calcining at 700°C for 7 hours to prepare copper-zinc co-doped nano-hydroxyapatite powder.

[0037] Among them, the molar ratio of the sum of copper atoms in copper sulfate, zinc atoms in zinc nitrate, and calcium atoms in calcium hydroxide to phosphorus atoms in phosphoric acid is 1.67:1. The molar ratio of copper atoms in copper sulfate to zinc atoms in zinc nitrate is 1:1, and the amounts of the two substances each account for copper atoms...

Embodiment 3

[0044] A preparation method of nano-copper and nano-zinc oxide dual-phase deposition of copper-zinc co-doped nano-hydroxyapatite, the steps are as follows:

[0045] (1) Copper and zinc ion doping: Under rapid stirring conditions, the phosphoric acid mixed solution containing copper sulfate and zinc nitrate is added dropwise to the calcium hydroxide suspension for reaction within 40-60 minutes, and the reaction is carried out after 6 hours by centrifugation , Ball milling for 3 hours, aging for 12 hours, washing, drying at 80°C for 12 hours, and calcining at 450°C for 9 hours to prepare copper-zinc co-doped nano-hydroxyapatite powder.

[0046] Among them, the molar ratio of the sum of copper atoms in copper sulfate, zinc atoms in zinc nitrate, and calcium atoms in calcium hydroxide to phosphorus atoms in phosphoric acid is 1.67:1. The molar ratio of copper atoms in copper sulfate to zinc atoms in zinc nitrate is 1:1, and the amounts of the two substances each account for copper atom...

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Abstract

The invention discloses nano-copper and nano-zinc oxide biphasic deposition copper-zinc co-doped nano-hydroxyapatite and a preparation method thereof. The preparation method comprises steps: preparingcopper-zinc co-doped nano-hydroxyapatite by using ion exchange principle, sequentially depositing nano-zinc oxide and nano-copper on the surface of the copper-zinc co-doped nano-hydroxyapatite by using a chemical deposition process to obtain nano-copper and nano-zinc oxide biphasic deposition copper-zinc co-doped nano-hydroxyapatite. According to the preparation method, nano-copper and nano-zincoxide are deposited on the surface of hydroxyapatite, meanwhile, co-doping of copper and zinc is achieved, the antibacterial activity and biological performance of hydroxyapatite can be improved through copper, and the bone structure is maintained; zinc can induce osteoblast proliferation and improve the biological activity and antibacterial property of hydroxyapatite. The codoping of copper and zinc plays a role in promoting the deposition of nano-copper and nano-zinc oxide on the surface of hydroxyapatite, a synergistic antibacterial effect can be generated among multiple ions, the antibacterial ability can be enhanced by combining two modification methods, and the release time of antibacterial ions is prolonged.

Description

Technical field [0001] The invention relates to a nano-copper, nano-zinc oxide dual-phase deposition of copper-zinc co-doped nano-hydroxyapatite and a preparation method thereof, and belongs to the field of biomedical material preparation. Background technique [0002] Hydroxyapatite is the main inorganic component of mineralized tissues such as bone and tooth enamel in mammals. Hydroxyapatite and CO doped 3 2- The carbonated apatite formed accounts for about 65% of the total bone mass. The synthetic nano-hydroxyapatite is very similar to the hydroxyapatite in bone in terms of element composition, crystal shape and structure. A large number of biological experiments have shown that nano-hydroxyapatite has the advantages of non-toxic, non-irritating and non-damaging biological tissues, especially its excellent biological activity, biocompatibility and osteoconductivity, and it is widely used as bone in clinical practice. Tissue repair materials and enamel remineralization materia...

Claims

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Application Information

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IPC IPC(8): C01B25/32A01N59/20A01N59/16A01P3/00A01P1/00B22F1/00B22F9/24C23C18/40B82Y30/00B82Y40/00
CPCC01B25/325A01N59/20A01N59/16B22F9/24B82Y30/00C23C18/40B82Y40/00C01P2004/04C01P2004/64B22F1/054
Inventor 郭超牛艺董寅生储成林盛晓波黄志海
Owner SOUTHEAST UNIV