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Preparation method of drug-loaded polycaprolactone-chitosan-silica hybrid fiber

A silica and hybrid fiber technology, applied in fiber treatment, pharmaceutical formula, fiber chemical characteristics, etc., can solve performance limitations and other problems, achieve the effect of improving hydrophilicity, reducing pollution, and improving safety

Active Publication Date: 2021-10-15
CHINA UNIV OF MINING & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the deficiencies in the prior art, provide a kind of preparation method of drug-loaded polycaprolactone-chitosan-silicon dioxide hybrid fiber, solve the problem of PCL, CS and SiO 2 The problem of performance limitations in single use, and the green method to obtain drug-loaded PCL-CS-SiO 2 Hybrid fiber

Method used

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  • Preparation method of drug-loaded polycaprolactone-chitosan-silica hybrid fiber
  • Preparation method of drug-loaded polycaprolactone-chitosan-silica hybrid fiber
  • Preparation method of drug-loaded polycaprolactone-chitosan-silica hybrid fiber

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Experimental program
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Effect test

Embodiment 1

[0042] Embodiment 1: 1.0g polycaprolactone and 0.075g chitosan are dissolved in 5mL, mass concentration is in the acetic acid solution of 90%, stir 12h at room temperature, add 4% (w / v) tetracycline hydrochloride after fully dissolving, Prepare the drug-loaded PCL-CS solution. Hydrolyze methyl orthosilicate for 2h under the catalytic condition of HCl (1M) to obtain clear and transparent SiO 2 Sol. Addition of SiO to drug-loaded PCL-CS solution 2 sol, making SiO 2 The mass percentage in the compound is 20%. After mixing and stirring for 2h, the drug-loaded PCL-CS-SiO was obtained 2 hybrid solution. Pour the spinning solution into the syringe, connect the positive pole to the needle, and the negative pole to the receiving plate, set the electrostatic field voltage to 15kV, the flow rate to 1mL / h, and the distance from the needle tip to the receiving plate to be 15cm, and perform electrospinning to obtain drug-loaded PCL- CS-SiO 2 hybrid fibers.

[0043] Experimental resu...

Embodiment 2

[0044] Embodiment 2: 1.25g polycaprolactone and 0.05g chitosan are dissolved in 5mL, mass concentration is in the acetic acid solution of 80%, stir 12h at room temperature, add 10% (w / v) vancomycin hydrochloride after fully dissolving prime, formulated as a drug-loaded PCL-CS solution. Under the catalytic condition of HCl (1M), hydrolyze ethyl orthosilicate for 48h to obtain clear and transparent SiO 2 Sol. Addition of SiO to drug-loaded PCL-CS solution 2 sol, making SiO 2 The mass percent content in the compound is 10%. After mixing and stirring for 2h, the drug-loaded PCL-CS-SiO was obtained 2 hybrid solution. Pour the spinning solution into the syringe, connect the positive electrode to the needle, and the negative electrode to the receiving plate, set the electrostatic field voltage to 17kV, the flow rate to 1.5mL / h, and the distance from the needle tip to the receiving plate to be 17cm, and perform electrospinning to obtain drug-loaded PCL -CS-SiO 2 hybrid fibers. ...

Embodiment 3

[0045] Embodiment 3: 0.5g polycaprolactone and 0.1g chitosan are dissolved in 5mL, mass concentration is in the acetic acid solution of 85%, stir 12h at room temperature, add 0.5% (w / v) adriamycin hydrochloride after fully dissolving prime, formulated as a drug-loaded PCL-CS solution. Hydrolyze methyl orthosilicate for 2h under the catalytic condition of HCl (1M) to obtain clear and transparent SiO 2 Sol. Addition of SiO to drug-loaded PCL-CS solution 2 sol, making SiO 2 The mass percentage in the compound is 30%. After mixing and stirring for 2h, the drug-loaded PCL-CS-SiO was obtained 2 hybrid solution. Pour the spinning liquid into the syringe, connect the positive electrode to the needle, and the negative electrode to the receiving plate, set the electrostatic field voltage to 20kV, the flow rate to 0.5mL / h, and the distance from the needle tip to the receiving plate to be 19cm, and perform electrospinning to obtain drug-loaded PCL -CS-SiO 2 hybrid fibers.

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Abstract

The invention discloses a preparation method of drug-loaded polycaprolactone-chitosan-silicon dioxide hybrid fiber, which belongs to the preparation method of hybrid fiber. The preparation method is: dissolving polycaprolactone (PCL) and chitosan (CS) in acetic acid solution; then adding the drug and stirring thoroughly to obtain a drug-loaded mixed solution; hydrolyzing the silicon source to obtain SiO 2 Sol, the SiO 2 The sol is added dropwise to the above drug-loaded mixed solution, and the spinning precursor solution is obtained after uniform stirring; the drug-loaded three-component hybrid fiber is prepared by using sol-gel combined with electrospinning technology. Advantages: The process method is simple, the repeatability is good, the raw materials are cheap and easy to obtain, the solvent used is non-toxic, non-polluting, green and environmentally friendly; PCL, CS and SiO 2 The three are hybridized, and the resulting hybrid fiber combines the advantages of the three single components to make up for their respective deficiencies and defects, and has good spinnability, superhydrophilicity, biological activity and drug release performance; the resulting hybrid fiber The fiber is in a uniform and continuous form; it is used in the field of biomedicine as a drug carrier material.

Description

technical field [0001] The invention relates to a preparation method of a hybrid fiber material, in particular to a preparation method of a drug-loaded polycaprolactone-chitosan-silicon dioxide hybrid fiber. Background technique [0002] The commonly used preparation methods of nanocomposite fibers include stretching, phase separation, spinning and so on. Among them, electrospinning is currently the only method that can directly and continuously prepare micro / nano composite fibers. The preparation process is simple and easy to operate, and the obtained fiber material has unique advantages such as small size, high porosity, and large specific surface area. Therefore, It is widely used in heavy metal adsorption, protective clothing, energy materials, drug sustained release, tissue engineering and other fields. Especially in the field of drug delivery, micro / nano drug-loaded fibers can delay and control drug release, with long-lasting drug effect and strong stability, which ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K47/36A61K47/04D01F8/14D01F8/18D01F1/10D01D5/00
CPCA61K47/02A61K47/34A61K47/36D01D5/003D01F1/10D01F8/14D01F8/18
Inventor 滕淑华周华建周艺博
Owner CHINA UNIV OF MINING & TECH
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