Preparation method and application of up-conversion nanorod

A nanorod and hydrothermal technology, applied in the field of biomedical materials, can solve problems such as poor drug treatment effect, and achieve the effects of improving hypoxia, high safety and high brightness.

Inactive Publication Date: 2020-11-06
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The tumor is highly hypoxic, res

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation method and tumor treatment of upconversion nanorods, the specific steps are as follows:

[0023] 1) Upconversion nanorods were synthesized by hydrothermal method.

[0024] 2) prepare respectively yttrium chloride, ytterbium chloride, and thulium chloride aqueous solution (the molar concentration is 1mol / L), prepare the sodium hydroxide solution (the molar concentration is 8mol / L), and prepare the fluoride solution (2mol / L )spare.

[0025] 3) Measure 8mL of sodium hydroxide solution and add it to a 250mL round-bottomed flask. While stirring, add 25mL of absolute ethanol and an equal volume of oleic acid. After stirring for 10min, the mixed solution turns from cloudy to clear.

[0026] 4) Add dropwise the chloride salt solution containing 20mmol rare earth elements (molar ratio Y 十 :Yb 3十 : Tm 3十 =75 / 25 / 0.3), continue to stir for 10min.

[0027] 5) Measure 5mL of ammonium fluoride solution, slowly add it dropwise into the round bottom flask, and conti...

Embodiment 2

[0033] The preparation method and tumor treatment of upconversion nanorods, the specific steps are as follows:

[0034] 1) Upconversion nanorods were synthesized by hydrothermal method.

[0035] 2) prepare respectively the aqueous solution of yttrium chloride, ytterbium chloride and thulium chloride (the molar concentration is 1mol / L), prepare the sodium hydroxide solution (the molar concentration is 8mol / L), and prepare the fluoride solution (2mol / L )spare.

[0036] 3) Measure 8mL of sodium hydroxide solution and add it to a 250mL round-bottomed flask. While stirring, add 25mL of absolute ethanol and an equal volume of oleic acid. After stirring for 10min, the mixed solution turns from cloudy to clear.

[0037] 4) Add dropwise the chloride salt solution containing 20mmol rare earth elements (molar ratio Y 十 :Yb 3十 : Tm 3十 =75 / 25 / 0.3), continue to stir for 10min.

[0038] 5) Measure 5mL of fluorinated hydrogen chloride solution, slowly add it dropwise into the round botto...

Embodiment 3

[0044] The preparation method and tumor treatment of upconversion nanorods, the specific steps are as follows:

[0045] 1) Upconversion nanorods were synthesized by hydrothermal method.

[0046] 2) Prepare mirror chloride solution, ammonium chloride and dichloride aqueous solution (molar concentration is 1mol / L) respectively, prepare sodium hydroxide solution (molar concentration is 8mol / L), prepare fluorinated sodium solution (2mol / L )spare.

[0047] 3) Measure 8mL of sodium hydroxide solution and add it to a 250mL round-bottomed flask. While stirring, add 25mL of absolute ethanol and an equal volume of oleic acid. After stirring for 10min, the mixed solution turns from cloudy to clear.

[0048] 4) Add dropwise the chloride salt solution containing 20mmol rare earth elements (molar ratio Y 十 :Yb 3十 : Tm 3十 =75 / 25 / 0.3), continue to stir for 10min.

[0049] 5) Measure 5mL of fluorinated hydrogen chloride solution, slowly add it dropwise into the round bottom flask, and con...

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Abstract

The invention discloses a preparation method and application of an up-conversion nanorod. The preparation method comprises the following specific steps: 1) synthesizing the up-conversion nanorod by utilizing a hydrothermal method; 2) respectively preparing water solutions of ytterbium chloride, yttrium chloride and thulium chloride; 3) weighing 8 mL of a sodium hydroxide solution, adding the sodium hydroxide solution into a 250-mL round-bottom flask, adding 25 mL of absolute ethyl alcohol and isometric oleic acid while stirring, and conducting stirring for 10 min to clarify the mixed solutionfrom turbidity; 4) dropwise adding a chlorate solution containing 20 mmol of rare earth elements, and conducting stirring; (5) measuring 5 mL of an ammonium fluoride solution, dropwise and slowly adding the ammonium fluoride solution into the round-bottom flask, and continuing to conduct stirring for 30 minutes until the solution becomes uniform liquid; and (6) transferring the prepared mixed solution into two 50-mL hydrothermal kettles, putting the hydrothermal kettles into a 180 DEG C drying oven for a reaction, conducting cooling to room temperature, carrying out centrifugal treatment, sequentially conducting repeated washing with ethanol and pure water multiple times, and removing a solvent to obtain a pure up-conversion crystal material.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method and application of upconversion nanorods. Background technique [0002] Chloroplast is a kind of organelle existing in higher plants, and the photosynthesis of higher plants mainly depends on the existence of chloroplasts. Chloroplasts can undergo photosynthesis due to the presence of chlorophyll, and the photosynthesis of chlorophyll reaches the maximum at a wavelength of 450nm, that is, the oxygen production of chloroplasts is the highest under blue light irradiation. Therefore, we looked for a material that can emit blue light to increase the oxygen production of chloroplasts. [0003] Up-conversion nanorods (UCNs) can emit low-energy light after being excited by high-energy light. Unlike the traditional typical light-emitting process (involving only one ground state and one excited state), the up-conversion process requires many intermedia...

Claims

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Application Information

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IPC IPC(8): C09K11/78A61K9/00A61K41/00A61P35/00
CPCA61K9/0009A61K41/0057A61P35/00C09K11/7769
Inventor 郑斌郭明明明东刘爽甘霖
Owner TIANJIN UNIV
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