Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A nicergoline tablet and technology for nicergoline, applied in the field of medicine, can solve the problems of low absolute bioavailability, low bioavailability, low dissolution rate and the like, and achieve the effects of increasing shelf life, increasing affinity, and increasing dissolution rate
Inactive Publication Date: 2020-11-10
SHANDONG FANGMING PHARMACEUTICAL CO LTD
View PDF7 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Due to the poor water solubility of Nicergoline, most of the oral preparations of Nicergoline currently on the market have the problems of low dissolution rate, poor absorption and low bioavailability after taking it. After testing, Nicergoline is rapidly absorbed after oral administration. , the absolute bioavailability is less than 5%
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0015] A kind of preparation method of Nicergoline tablet, (1) Nicergoline, carboxymethyl starch sodium, hypromellose, starch, mannitol, water are mixed uniformly to make pill ointment, and pill ointment is molded (2) add Nicergoline, oil for injection, phosphatidylglycerol, pregelatinized starch, microcrystalline cellulose in ethanol and stir until Nicergoline is completely dissolved at a rotating speed of 500r / min, then Remove ethanol, and add corn fiber to obtain the main medicinal ointment, the surface of the pill is coated with the main medicinal ointment, dried, and pressed into tablets to obtain a pill coated with the second main medicinal layer; (3) gum arabic, lactose, pectin, medicine Mix gelatin, cornstarch and pigment evenly to prepare a coating paste, put the pills coated with the second main drug layer in a fluidized bed coating device for bottom spraying and coating, and dry to obtain the inner layer of the coating. (4) coating the main drug ointment on the surf...
Embodiment 2
[0023] A kind of preparation method of Nicergoline tablet, (1) Nicergoline, carboxymethyl starch sodium, hypromellose, starch, mannitol, water are mixed uniformly to make pill ointment, and pill ointment is molded (2) add Nicergoline, oil for injection, phosphatidylglycerol, pregelatinized starch, microcrystalline cellulose in ethanol and stir until Nicergoline is completely dissolved at a rotating speed of 500r / min, then Remove ethanol, and add corn fiber to obtain the main medicinal ointment, the surface of the pill is coated with the main medicinal ointment, dried, and pressed into tablets to obtain a pill coated with the second main medicinal layer; (3) gum arabic, lactose, pectin, medicine Mix gelatin, cornstarch and pigment evenly to prepare a coating paste, put the pills coated with the second main drug layer in a fluidized bed coating device for bottom spraying and coating, and dry to obtain the inner layer of the coating. (4) coating the main drug ointment on the surf...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention relates to the technical field of medicine, in particular to a preparation method of a nicergoline tablet. The nicergoline tablet is sequentially provided with a pill, a second main medicine layer, a coating inner layer, a first main medicine layer and a coating outer layer from inside to outside; and the thickness ratio of the second main medicine layer to the coating inner layer tothe first main medicine layer to the coating outer layer is (1-2):(4-5):(1-2):(1-2). a tablet inner layer is arranged, so that the medicine can be disintegrated hierarchically, the action time of themedicine is prolonged, and absorption is facilitated; and the nicergoline is uniformly dispersed in phospholipid, so that the affinity between the nicergoline and grease is increased, the dissolutionrate of the nicergoline is further increased, and the utilization rate is increased. By arranging a hollow tablet shell, the dissolution time of the tablet shell is shortened, the medicine is exposedas soon as possible to play a role, and a patient is treated with the medicine early; in addition, the tablet shell contains gelatin and corn starch, so that the tablet shell is softened and decomposed when meeting water and can be absorbed by the human body, and the dissolution time of the tablet shell is also shortened;.
Description
technical field [0001] The application belongs to the technical field of medicine, in particular to a preparation method of Nicergoline tablets. Background technique [0002] Nicergoline is a semi-synthetic ergot alkaloid derivative with alpha-receptor blocking and vasodilator effects. It can strengthen the metabolism of brain cell energy, increase the utilization of oxygen and glucose, promote the conversion of neurotransmitter dopamine to enhance nerve conduction, strengthen brain protein biosynthesis, and improve brain function. [0003] Nicergoline is prepared as a raw material to obtain pharmaceutical preparations, including tablets, capsules, water injections, and freeze-dried powder injections. Due to the poor water solubility of Nicergoline, most of the oral preparations of Nicergoline currently on the market have the problems of low dissolution rate, poor absorption and low bioavailability after taking it. After testing, Nicergoline is rapidly absorbed after oral a...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more