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Medicine composition for skin mucous membrane nursing and wound repair and preparation method of medicine composition

A technology of wound repair and composition, which is applied in the field of pharmaceutical compositions, can solve problems such as insufficient stability, and achieve remarkable effects, great clinical application value and social benefits, and easy-to-obtain preparation raw materials

Inactive Publication Date: 2020-11-10
尚源 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that small-molecule hyaluronic acid has physiological activities such as moisturizing, anti-oxidation, promoting wound healing, and promoting angiogenesis. However, when it is applied to the skin surface, it is not stable enough, and the retention time is shorter than the wound healing time. Therefore, it is limited. Applications

Method used

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  • Medicine composition for skin mucous membrane nursing and wound repair and preparation method of medicine composition
  • Medicine composition for skin mucous membrane nursing and wound repair and preparation method of medicine composition
  • Medicine composition for skin mucous membrane nursing and wound repair and preparation method of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of embodiment 1 low molecular weight chitosan

[0025] Chitosan 20g (derived from North Atlantic white crab, deacetylation degree 95%, moisture 5%, ash content 0.5%, viscosity average molecular weight 100,000) was dissolved with acetic acid 800ml, chitosan concentration was 0.025g / ml, added Hydrolyze 6ml of the mixed enzyme composed of pectinase 27u and bromelain 33u, after hydrolyzing 40mim at 50°C, adjust the pH value to 6.7 with 0.1mol / L sodium hydroxide solution, continue to degrade at 65°C for 3h, inactivate the enzyme at 110°C for 15min, centrifuge The supernatant was obtained and freeze-dried to obtain 17.81 g of solid powder. Through HPLC test, it is confirmed that it is chitosan with low molecular weight, the average molecular weight is 860, and the purity is more than or equal to 99.5%.

Embodiment 2

[0026] The preparation of embodiment 2 low molecular weight hyaluronic acid

[0027] Take 20g of hyaluronic acid (purchased from Bloomage Biotechnology Co., Ltd., average molecular weight 1,000,000), prepare 0.5g / 100ml hyaluronic acid aqueous solution, and distribute it into four 500ml sterilized reagent bottles, each reagent bottle Medium 200ml. Using Co 60 - Irradiate with a gamma irradiation device, and the irradiation dose is 3kGy respectively. The treated samples are placed at 4° C. for 2 hours and then freeze-dried to obtain a total of 15.5 g of powdery solids. Measured by Fourier transform infrared spectrometer, its average molecular weight is 6500.

Embodiment 3

[0028] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0029] Small molecular weight chitosan, the average molecular weight is 860, and the purity is ≥ 99.5%, and it is prepared in Example 1. Low-molecular-weight hyaluronic acid, with an average molecular weight of 6500, was prepared in Example 2.

[0030] Glycine, serine, arginine, glycerin, carbomer, polyvinyl alcohol, polyethylene glycol, carboxymethyl cellulose, Nanqian bamboo, bowl flower grass, purple pearl grass, and salvia miltiorrhiza are all commercially available, and distilled water is homemade (Stainless steel electric water distiller, model: ZLSC-5).

[0031]In the 1000ml flask, add 2g Nanqian bamboo, 2g bowl flower grass, 2g purple pearl grass, 2g salvia miltiorrhiza, 200ml distilled water, stir evenly, heat and reflux for 3 hours, filter, and distill under reduced pressure (60 ℃, 10kPa), reduce the filtrate Concentrate under pressure to half of the original volume, cool t...

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Abstract

The invention discloses a medicine composition for skin mucous membrane nursing and wound repair. The medicine component consists of 1%-10% of small molecular weight chitosan, 1%-10% of small molecular weight hyaluronic acid, 0.5%-3% of glycine, 0.5%-3% of serine, 0.5%-2% of arginine, 1%-6% of glycerol, 0.1%-2% of carbomer, 0.5%-2% of polyvinyl alcohol, 0.5%-3% of polyethylene glycol, 0.5%-2% of carboxymethyl cellulose, 1.5%-4% of nandina domestica Thunb. fruits, 1%-4% of thunbergia fragrans roxb. stems and leaves, 1%-3% of c allicarpa macrophylla Vahl, 1%-2% of salvia miltiorrhiza and 44%-89.4% of distilled water. The medicine composition disclosed by the invention overcomes the defects of existing medicines, has a remarkable effect on skin mucous membrane nursing and wound repair, and has a relatively great clinical application prospect. The medicine preparation disclosed by the invention is easily available in raw materials, simple in preparation method, suitable for industrial production and relatively high in application value.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for skin and mucous membrane care and wound repair and a preparation method thereof. Background technique [0002] Hyaluronic acid is a macromolecular mucopolysaccharide, which is an important physiological substance in the human body. Studies have found that small-molecule hyaluronic acid has physiological activities such as moisturizing, anti-oxidation, promoting wound healing, and promoting angiogenesis. However, when it is applied to the skin surface, it is not stable enough, and the retention time is shorter than the wound healing time. Therefore, it is limited. Applications. [0003] Chitosan is a secondary product obtained from chitin through biodegradation or other methods, and has a wide range of sources. After making chitosan into small molecules, it is found that it has the characteristics of stable spatial structure, high water solubility,...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P17/02A61P27/02A61P31/02A61P31/04A61P31/10A61K31/728A61K31/722
CPCA61K31/722A61K31/728A61K36/19A61K36/537A61K36/85A61K36/899A61K2236/331A61K2236/51A61K2236/53A61P17/02A61P27/02A61P31/02A61P31/04A61P31/10A61K2300/00
Inventor 尚源邵瑞涛
Owner 尚源
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