Lung-heat-clearing pharmaceutical composition and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of excessive precipitation, large oral dosage, inaccurate dosage, etc., and achieve the effect of increasing the effect of nourishing lung yin

Active Publication Date: 2020-11-27
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the compatibility of this prescription is mainly attacking, clearing, and purging, lacking Yin-nourishing and Qi-tonifying medicines, and the prevention and treatment of pulmonary fibrosis are not very targeted. Modern people's low immunity is usually due to Qi and blood problems, and too clearing Attack is not suitable for immunocompromised patients, ...

Method used

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  • Lung-heat-clearing pharmaceutical composition and preparation method thereof
  • Lung-heat-clearing pharmaceutical composition and preparation method thereof
  • Lung-heat-clearing pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Establish the fingerprints of chlorogenic acid, caffeic acid, p-coumaric acid, scutellarin, rosmarinic acid, and apigenin

[0022] When selecting the evaluation index of extraction rate, the active ingredient p-coumaric acid in Hedyotis diffusa, which is also the active ingredient in Scutellaria barbata; Fritillin B. Chlorogenic acid, caffeic acid, scutellarin, rosmarinic acid, and apigenin are active ingredients in other medicinal materials. Such selection can more comprehensively reflect the efficiency of Qingfei oral liquid reflux extraction.

[0023] 1.1 Preparation of reference substance stock solution

[0024] Precisely weigh 4.37 mg and 5.90 mg of the reference substances of chlorogenic acid and caffeic acid, respectively, and place them in 5ml measuring bottles; 5.71, 4.67, and 2.38mg were placed in 10ml measuring bottles, dissolved in methanol and diluted to the mark, and shaken to obtain concentrations of 0.874mg / ml, 1.18mg / ml, 0.626mg / ml, and 0....

Embodiment 2

[0044] Embodiment 2: peiminin A, peiminin B content assay method

[0045] Chromatographic conditions: chromatographic column is Kromasil C18, mobile phase: acetonitrile-water-diethylamine (70:30:0.03), flow rate: 0.7ml / min, column temperature: 30°C, evaporative photodetector, drift tube temperature: 45 °C, nitrogen flow rate 1.5L / min. External standard two-point determination method: Precisely draw 10 μl and 20 μl of the reference solution and 10 μl of the test solution respectively, inject them into the liquid chromatograph, and measure. Use the logarithmic equation to calculate the contents of peimin A and peimin B respectively. Preparation of the test solution: Rotate the test solution in 1.2 at 80°C to 90ml to obtain a concentrated medicinal solution containing 2.5g of crude drug per milliliter. Accurately draw 10ml of the concentrated medicinal solution, place it in a flask, and add 0.8 g of the concentrated ammonia test solution. ml soaked for 1.5 hours, precisely adde...

Embodiment 3

[0046] Embodiment 3: Orthogonal test investigation of extraction process conditions of Qingfei Oral Liquid

[0047] 3.1 Transfer rate

[0048] The transfer rate of 8 active ingredients including chlorogenic acid, caffeic acid, p-coumaric acid, scutellarin, rosmarinic acid, apigenin, peimin A and peimin B were used as evaluation indexes to investigate the preparation process.

[0049] 3.2 Anointing rate

[0050] The extraction rate of traditional Chinese medicine mixture refers to the percentage of the weight of the extract after concentrating the Chinese medicinal liquid into the extract to the weight of the original medicinal material. The extraction rate of the traditional Chinese medicine can indicate the extraction efficiency of the traditional Chinese medicinal material. Determination method: Take 200ml of the test solution in an evaporating dish dried to constant weight, evaporate to dryness in a water bath at 80°C, transfer the evaporating dish to a drying oven, dry at...

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Abstract

The invention provides a lung-heat-clearing pharmaceutical composition and a preparation and extraction process thereof. The lung-heat-clearing pharmaceutical composition can be used for treating pulmonary fibrosis. The pharmaceutical composition is prepared from the following components: solanum nigrum, lily bulb, selfheal, thunberg fritillary bulb, paris polyphylla, prepared rhizoma polygonati,adenophora stricta, sculellaria barbata and oldenlandia diffusa, and can be prepared into an oral liquid form. A fingerprint spectrum is prepared from chlorogenic acid, caffeic acid, p-coumaric acid,scutellarin, rosmarinic acid and apigenin; the contents of peiminine and peiminine are detected, the transfer rates of the eight effective components are used as evaluation indexes to investigate thepreparation process, and the preferable extraction process comprises the following steps of soaking the medicinal materials for 1 hour, extracting twice with water of 8 times of volume or 50% ethanol,and extracting for 1.5 hours each time. The transfer rate reaches 120% or above, and the paste yield is 30%.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a lung-clearing medicinal composition and a preparation process, in particular to a traditional Chinese medicine Qingfei oral liquid. Background technique [0002] With the development of urbanization, the population density is increasing day by day, and the personal work pressure continues to increase. Many people are in a state of sub-health and low immunity. The air pollution caused by industrial development makes respiratory diseases more and more common and serious. Especially with the epidemic pneumonia bacterial virus, the lung immune system is the first to be attacked. In addition, smoking, mining, and allergies to industrial waste gas and dust can all cause damage to the lungs, requiring lung maintenance and treatment of related diseases. [0003] Qingfei Mixture commonly used in clinical practice originated from Qingfei Formula, which was first seen in "Jingyue Quanshu", Mianli J...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/08A61P11/00
CPCA61K9/0095A61K36/23A61K36/34A61K36/342A61K36/536A61K36/539A61K36/748A61K36/81A61K36/896A61K36/8966A61K36/8967A61K36/8969A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61P11/00A61K2300/00
Inventor 黄萍张轶雯潘宗富郑小卫邹小舟刘宇佳盛孔胜
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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