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Adhesive self-repairing hemostatic sponge and preparation method thereof

A hemostatic sponge and self-repairing technology, which can be used in medical formulations, surgery, drug delivery, etc., can solve the problems of inability to stimulate the endogenous hemostatic process and poor hemostatic effect, and achieve the goal of accelerating hemostatic efficiency, preventing displacement, and increasing swelling rate Effect

Active Publication Date: 2021-10-19
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the seal cannot stimulate the endogenous hemostatic process, and also has the problem of poor hemostatic effect

Method used

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  • Adhesive self-repairing hemostatic sponge and preparation method thereof
  • Adhesive self-repairing hemostatic sponge and preparation method thereof
  • Adhesive self-repairing hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1: 2.5% dopamine was grafted with oxidized alginic acid (85% oxidation degree, 15% dopamine grafting rate, and 300 mPa·s viscosity), 30% acrylamide, 13% acrylic acid, 0.015% N , N'-methylenebisacrylamide is added to purified water, stirred at 100-200rpm until it is completely dissolved, then sodium hydroxide solution is added dropwise to neutrality, 1.2% ammonium persulfate, 0.5% sodium bisulfite, 0.4 % calcium chloride, stirred evenly at 100-200rpm, and reacted at 60°C for 3h under the protection of nitrogen to obtain a gel-like product. The gel product is placed in purified water 10 times its own weight after swelling, and is dialyzed for 24 hours under stirring at 50-100 rpm (purified water is replaced once every 8 hours, a total of 3 times of dialyzing), and the condensation of redox initiators can be removed. Gel-like product. The gel-like product after dialysis is placed in a mold, placed in a freeze dryer at -50°C for 4 hours, and vacuumed after the end,...

Embodiment 2

[0055] Example 2 Graft oxidized alginic acid with a mass fraction of 3.5% dopamine (oxidation degree is 80%, dopamine grafting rate is 10%, viscosity is 200mPa·s), 20% acrylamide, 20% acrylic acid, 0.01% N , Add N'-methylenebisacrylamide to purified water, stir at 100-200rpm until completely dissolved, add sodium hydroxide solution and disodium hydrogen phosphate solution to neutrality, add 1.1% ammonium persulfate, 0.5% Sodium bisulfite, 0.4% calcium sulfate, stirred evenly at 100-200rpm, and reacted at 60°C for 3h under the protection of nitrogen to obtain a gel-like product. The gel product is placed in purified water 10 times its own weight after swelling, and is dialyzed for 24 hours under stirring at 50-100 rpm (purified water is replaced once every 8 hours, a total of 3 times of dialyzing), and the condensation of redox initiators can be removed. Gel-like product. The gel-like product after dialysis is placed in a mold, placed in a freeze dryer at -50°C for 4 hours, an...

Embodiment 3

[0056] Example 3 Graft oxidized alginic acid with a mass fraction of 1.5% of dopamine (90% oxidation degree, 20% dopamine grafting rate, and 500 mPa·s viscosity), 25% acrylamide, 13% acrylic acid, 0.02% N , N'-methylenebisacrylamide is added to purified water, stirred at 100-200rpm until it is completely dissolved, then sodium hydroxide solution and sodium bicarbonate solution are added dropwise to neutrality, 1.0% ammonium persulfate, 0.5% sulfite Sodium bisulfate, 0.5% calcium carbonate, stirred evenly at 100-200rpm, and reacted at 60°C for 3h under the protection of nitrogen to obtain a gel-like product. The gel product is placed in purified water 10 times its own weight after swelling, and is dialyzed for 24 hours under stirring at 50-100 rpm (purified water is replaced once every 8 hours, a total of 3 times of dialyzing), and the condensation of redox initiators can be removed. Gel-like product. The gel-like product after dialysis is placed in a mold, placed in a freeze ...

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Abstract

The invention discloses an adhesive self-repairing hemostatic sponge and a preparation method thereof. The hemostatic sponge is prepared by grafting dopamine with oxidized alginic acid, acrylamide, acrylic acid, and N,N'-methylenebisacrylamide after neutralization, adding coagulation cross-linking agent and redox initiator for cross-linking, and programmed freeze-drying. . The hemostatic sponge prepared by the invention can not only quickly absorb blood or infiltrate, form a gel, form compression on damaged blood vessels on the surface of the cavity, and promote hemostasis, but also adhere to the surface of the cavity to further promote hemostasis and prevent displacement. The hemostatic sponge of the present invention can form a dynamic bond after absorbing blood or osmotic fluid, and has a certain self-repairing function. Therefore, the hemostatic sponge has the effects of fast and efficient hemostasis, adhesion and self-repair.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to an adhesive self-repairing hemostatic sponge and a preparation method thereof. The medical hemostatic sponge of the present application has the functions of rapid expansion and hemostasis, adhesion, displacement prevention and self-repair. Background technique [0002] In the first aid of sudden accidents, surgery and in war, 50% of the deaths are caused by massive bleeding. Some traditional hemostatic materials, such as hemostatic gauze, hemostatic bandage, hemostatic cotton yarn, etc., have limited hemostatic ability, and the hemostatic effect is not very satisfactory. Therefore, the development of highly efficient and quickly absorbable hemostatic materials and products, which can effectively stop bleeding within 1-2 minutes or even shorter after the bleeding occurs, has become one of the main goals of the research and development of hemostatic materials. Hemostat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/02A61L24/00C08F251/00C08F220/56C08F220/06C08F222/38
CPCA61L24/001A61L24/0036A61L24/02A61L24/06A61L24/08A61L2400/04C08F251/00C08L51/02C08L5/04C08F220/56C08F220/06C08F222/385
Inventor 张海军袁坤山张淑欣车超越侯文博尹玉霞鲁守涛段翠海
Owner SHANDONG BRANDEN MEDICAL DEVICE
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