Active artificial blood vessel capable of achieving repeated puncture and preparation method thereof

Abstract

The invention discloses an active artificial blood vessel capable of achieving repeated puncture and a preparation method thereof, belongs to the field of tissue engineering, and particularly relatesto an autologous endothelialization tissue engineering blood vessel capable of achieving repeated puncture, a preparation method thereof and a vascular skeleton for preparing the autologous endothelialization tissue engineering blood vessel capable of achieving repeated puncture. The preparation method of the autologous endothelialization engineering blood vessel capable of achieving repeated puncture comprises the following steps: implanting the vascular skeleton into an animal or a human body, enabling the vascular skeleton and a blood vessel of the animal or the human body to be connected in parallel and sewn, and taking out the sewn vascular skeleton after 7-62 days to obtain the autologous endothelialization tissue engineering blood vessel capable of achieving repeated puncture. The artificial blood vessel has the beneficial effects that: intimal hyperplasia and thrombus can be effectively inhibited; autologous blood vessels at any position can be replaced, and endothelializationblood vessels of corresponding sizes can be customized according to needs; and the preparation technology is high in controllability, the mechanical property and the cell mobility of a vascular skeleton are controlled by controlling a skeleton structure (wall thickness, fiber diameter, pore diameter, layer number and textile angle), and the gold standard of the artificial blood vessel is achieved.

Description

technical field [0001] The invention belongs to the field of biological materials and tissue engineering, and in particular relates to a puncture-resistant active artificial blood vessel and a preparation method thereof. Background technique [0002] Hemodialysis is the most effective measure to rescue acute and chronic renal failure, and can prolong the life of patients to a great extent. In kidney dialysis treatment, the patient's blood is extracted from the artery, processed by the hollow fiber dialyzer, and then injected into the patient's body through the vein, so as to correct the electrolyte and acid-base balance disorder of the body. Clinically, in the case of high blood flow and high dialysate flow, the toxin clearance rate per unit time will increase with the increase of blood flow or dialysate flow rate, so in order to achieve a higher toxin clearance rate and shorten the During dialysis treatment, a relatively high blood flow rate, usually greater than 200 mL / mi...

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide an active artificial blood vessel that can be punctured multiple times and its preparation method, so that the obtained artificial blood vessel can be punctured in the early stage, and automatically rebound after puncture, without leakage, and its parameters Stable, high bending strength, rapid cellularization in humans and / or animals, good long-term tissue regeneration ability, can meet the needs of hemodialysis for blood flow and long-term puncture resistance of vascular access