Preparation process of capryloyl hydroxamic acid

Abstract

The invention relates to the field of chemical synthesis, and particularly discloses a preparation process of capryloyl hydroxamic acid, which comprises the following steps: preparing ethyl n-caprylate, and preparing the capryloyl hydroxamic acid, wherein the ethyl n-caprylate is prepared by the following steps: mixing 1-1.5 kg of n-caprylic acid with 0.35-0.7 kg of ethanol, adding solid superacid, performing heating reflux for 5-7 hours, filtering to obtain precipitate and filtrate, and performing reduced pressure distillation on the filtrate to obtain the ethyl n-caprylate, and the obtainedprecipitate is washed and roasted to obtain the solid superacid, and the solid superacid is recycled to the preparation step of the ethyl n-caprylate for use. By using the solid superacid catalyst, the environmental friendliness of the esterification reaction in the n-capryloyl hydroxamic acid preparation process is improved.

Description

technical field

[0001] The application relates to the field of chemical synthesis, more specifically, it relates to a preparation process of caprylyl hydroxamic acid. Background technique

[0002] Caprylyl hydroxamic acid, also known as caprylyl hydroxamic acid, is an organic acid that can maintain a non-ionized state from acidic to neutral. It has high-efficiency chelation, can inhibit the active elements required by mold, and limit microorganisms. The environment required for growth is an ideal antibacterial agent and is widely used in the fields of cosmetics, medicine and fine chemicals.

[0003] In the preparation process of octanoyl hydroxamic acid, it is usually first to generate n-octanoic acid ethyl ester through n-octanoic acid and ethanol under the catalysis of sulfuric acid; Obtain n-octanoyl hydroxamic acid.

[0004] In related industrial production, homogeneous catalysts are generally used for the esterification reaction of n-octanoic acid and ethanol. Homogen...