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Aloe arborescens antibacterial gel for infantile eczema

A technology of baby eczema and aloe vera, which is applied in cosmetic preparations, skin care preparations, medical preparations with non-active ingredients, etc. It can solve the problems of uncertain product toxicity and poor stability, and achieve the goal of keeping the skin moist and healing time Short-term effect with low recurrence rate

Active Publication Date: 2021-03-19
山东爱维德生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above problems, develop safe gel products suitable for infant eczema, solve the problems of uncertain toxicity and poor stability of existing products, prevent infant skin infection, and ensure the normal growth and development of infants. The purpose of the present invention is to provide A kind of antibacterial gel of Aloe arborescens for infant eczema

Method used

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  • Aloe arborescens antibacterial gel for infantile eczema
  • Aloe arborescens antibacterial gel for infantile eczema

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preparation example Construction

[0052] The present invention also includes a preparation method of the Aloe arborescens antibacterial gel for infant eczema, comprising the following steps:

[0053] (1) In parts by weight, take 0.5-0.7 parts of Aloe arborescens extract and 1-3 parts of γ-polyglutamic acid modified chitosan, add them to 100 parts of water, ultrasonicate for 10-30 minutes, and put them at a temperature of 20-40°C Stir for 1 to 3 hours to obtain the first solution;

[0054] (2) Add 0.4-0.6 parts of sodium hyaluronate to 20 parts of water, stir for 0.5-1.5 hours, add the resulting mixture into the first solution, ultrasonicate for 10-30 minutes, and stir at 20-40°C for 1-3 hours. Obtain the second solution;

[0055] (3) Add 0.05-0.15 parts of polyethylene glycol phospholipid, 2-3 parts of glycerin and 0.01-0.3 parts of palmitoyl dipeptide-5 into 20 parts of water, stir for 30-50 minutes, and add the obtained emulsion into the second solution, Sonicate for 10-30 minutes, and stir at 20-40°C for ...

Embodiment 1

[0061] Preparation of Aloe arborescens Extract

[0062] Aloe arborescens extract is prepared according to the published method of patent CN107334908A: take fresh aloe vera arborescens leaves, wash them, dry them with hot air until the moisture content is lower than 10%, grind them, pass through a 60-mesh sieve to obtain aloe vera powder, take 500 g of the obtained aloe vera powder and add In 50 liters of 50% ethanol aqueous solution, adopt microwave extraction method to carry out first extraction, power 400W, temperature 40 ℃, extraction time 3 hours, filter after extraction is completed, filter cake joins 50 liters of 50% n-butanol aqueous solution In the second extraction, the microwave extraction method was used for the second extraction, the power was 80W, the temperature was 40°C, and the extraction time was 3 hours. After the extraction was completed, it was filtered, and the filtrate obtained from the two extractions was combined, concentrated, and vacuum-dried to obtain...

Embodiment 2

[0064] Preparation of γ-polyglutamic acid modified chitosan:

[0065] ① Take 100g of γ-polyglutamic acid and add it to 500g of dimethyl sulfoxide, add 10g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 9g of N- Hydroxysuccinimide, the resulting mixture was stirred at 10°C for 1 hour, 8000g of ethyl acetate was added, stirred for 20 minutes, filtered, the filter cake was washed with 1000g of acetonitrile and then vacuum-dried at 20°C to obtain a solid one;

[0066] ② Take 200g chitosan and add it to the mixture of 10000g dimethyl sulfoxide and 0.5 mol / liter sodium chloride aqueous solution (the volume ratio of dimethyl sulfoxide and 0.5 mol / liter sodium chloride aqueous solution is 1:2) , stirred for 30 minutes, added the solid 1 obtained in step ①, raised the temperature to 30° C., and stirred for 10 hours to obtain a reaction solution, which was dialyzed for 24 hours with a dialysis bag with a molecular weight of 3500, and freeze-dried to obtain modified γ...

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Abstract

The invention discloses aloe arborescens antibacterial gel for infantile eczema and a preparation method thereof. The aloe arborescens antibacterial gel is prepared from the following raw materials ofan aloe arborescens extract, gamma-polyglutamic acid modified chitosan, sodium hyaluronate, polyethylene glycol phospholipid, allantoin and the like. The prepared gel has a good treatment effect on eczema, eczema of most patients can be well treated, the healing time is short, the recurrence probability of the patients is relatively low, and anaphylactic reaction is avoided; gamma-polyglutamic acid is adopted to modify the structure of chitosan, carboxyl in gamma-polyglutamic acid and amino in chitosan are condensed to prepare a novel macromolecular reticular structure, and meanwhile, the characteristic that chitosan is insoluble in water is improved, so that chitosan forms a high-adsorption reticular gel structure in water, and a certain slow-release effect is achieved; and mucopolysaccharide and the chitosan have relatively good compatibility, so that a uniform and stable gel solution can be formed, and the product is prevented from generating precipitate at an over-high or over-lowtemperature.

Description

technical field [0001] The invention relates to the technical field of gel cosmetics, in particular to an aloe arborescens antibacterial gel for infant eczema, and the invention also includes a preparation method of the gel. Background technique [0002] Aloe arborescens is a natural plant with rich nutrition and outstanding medicinal value. It is widely planted in many regions of my country. Aloe arborescens has been used as a traditional Chinese medicine for thousands of years. It has the effects of purging, clearing the liver and killing insects. Studies in recent years have shown that Aloe arborescens is rich in saponins, flavonoids, proteins, and amino acid compounds, as well as a large amount of mucopolysaccharides and trace elements. It has anti-eczema, anti-oxidation, anti-inflammatory, antibacterial, anti-aging, Moisturizing, beauty and whitening and other pharmacological activities. In addition, Aloe arborescens is a pure natural plant, non-toxic and harmless, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/64A61K8/73A61K8/88A61K8/04A61K36/886A61K36/896A61K9/06A61K38/05A61K47/10A61K47/22A61K47/24A61K47/61A61P17/00A61Q17/00A61Q19/00
CPCA61K8/9794A61K8/042A61K8/88A61K8/735A61K8/64A61Q17/005A61Q19/00A61K36/896A61K36/886A61K9/06A61K9/0014A61K47/61A61K47/24A61K38/05A61K47/10A61K47/22A61P17/00A61K2800/82A61K2800/592Y02A50/30
Inventor 马启冠张海峰张玙璠赖培錡
Owner 山东爱维德生物科技有限公司
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