Material with biological anti-pollution function, and preparation method and application thereof

A functional and biological technology, applied in the directions of medical formulation, tissue regeneration, drug delivery, etc., can solve problems such as restricting the application of inferior vena cava filters, poor blood compatibility, and increased surgical failure, so as to improve blood compatibility and improve blood circulation. Compatibility, the effect of inhibiting adhesion and proliferation

Pending Publication Date: 2021-04-23
CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above complications will increase the risk of permanent filter failure, and for the retrievable inferior vena cava filter, the intima coverage will cause the filter to adhere to the blood vessel, making the recovery window period of the filter smaller and more difficult to recover. Increased risk of surgical failure
[0004] It can be seen that the existing inferior vena cava filter has the problems of poor hemocompatibility and the inability to effectively inhibit cell adhesion and proliferation to form intima tissue, making the filter difficult or even unrecyclable. These problems restrict the quality of the inferior vena cava to a certain extent. filter application

Method used

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  • Material with biological anti-pollution function, and preparation method and application thereof
  • Material with biological anti-pollution function, and preparation method and application thereof
  • Material with biological anti-pollution function, and preparation method and application thereof

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preparation example Construction

[0023] The embodiment of the present invention also provides a preparation method of a material with biological antifouling function, please refer to figure 1 , including the following steps:

[0024] S1. Formation of polyamine-phenol coating

[0025] The substrate deposited with the polydopamine coating is reacted with a polyamine molecular solution to form a polyamine-phenol coating on the substrate, and the polyamine-phenol coating formed after this reaction contains a large number of amine groups, which is convenient Introduce additional functionalized coatings.

[0026] Specifically, the preparation process of the substrate deposited with the polyamine-phenol coating includes: soaking the substrate in a mixed solution formed of catechol monomer and tris buffer solution, and reacting for 1-24 hours. The preparation of the polyamine-phenol coating is an existing process, and in tris (TRIS) buffer solution (the pH value of the control solution is 7-10, such as 7, 8, 8.5, 9...

Embodiment 1

[0040] This embodiment provides a method for preparing a material with biological antifouling function, comprising the following steps:

[0041] (1) Soak the inferior vena cava filter in a Tris (pH 8.5) buffer solution containing 1 mg / mL dopamine, react at room temperature for 12 hours, and then ultrasonically clean it with ultrapure water, put it into a buffer solution containing 10 μg / mL polyallylamine (molecular weight About 10000Da) of 2.5mg / mL NaOH aqueous solution, soak for 6 hours, and obtain a layer of wear-resistant and amine-rich coating (marked as PAM@DA) on the surface of the inferior vena cava filter.

[0042] (2) Mix MES, EDC, NHS, hyaluronic acid (molecular weight 1000KDa) and water to form a 20mL solution and react for 20min, wherein the concentrations of MES, EDC, NHS and hyaluronic acid are 10mg / mL, 1mg / mL, 0.24mg / mL and 2mg / mL. After immersing the inferior vena cava filter obtained in (1) with the PAM@DA coating on the surface for 12 hours in the reacted so...

Embodiment 2

[0044] This embodiment provides a method for preparing a material with biological antifouling function, comprising the following steps:

[0045] (1) Soak the inferior vena cava filter in Tris (pH 8.5) solution of 0.8mg / mL dopamine, react at room temperature for 12 hours, after cleaning, put it into 2.0 mg / mL NaOH aqueous solution, soaked for 4 hours, and obtained a wear-resistant and amine-rich dopamine conversion coating (PAM@DA) on the surface of the inferior vena cava filter.

[0046] (2) Mix MES, EDC, NHS, hyaluronic acid (molecular weight of 5KDa) and water to form a 20mL solution and react for 10min, wherein the concentrations of MES, EDC, NHS and hyaluronic acid are 8mg / mL, 0.8mg / mL , 0.2mg / mL and 1mg / mL. After immersing the inferior vena cava filter obtained in (1) with the PAM@DA coating on the surface for 10 hours in the reacted solution, a functional coating of the inferior vena cava filter with anti-adhesion function can be obtained .

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Abstract

The invention discloses a material with a biological anti-pollution function and a preparation method and application thereof, and relates to the technical field of biological materials. The material with the biological anti-pollution function comprises a base material, a polyaminophenol coating and a hyaluronic acid layer, Wherein the polyaminophenol coating is obtained by reaction of phenolic molecules and polyamine molecules. The preparation method comprises the following steps: forming the polyaminophenol adhesive coating on the base material by utilizing a phenol-amine chemical coating technology, and then covalently grafting hyaluronic acid by utilizing amino groups on the polyaminophenol adhesive coating to form a hyaluronic acid coating. After the coating is in contact with an aqueous solution, a hydration layer is formed on the surface to form a super-hydrophilic surface, so that adhesion, migration and proliferation of components, endothelial cells, smooth muscle cells, inflammatory cells and the like in blood and a coating modified material are effectively inhibited, and therefore, the material with the biological anti-pollution function can be prepared and formed as follows: a vena cava filter, an artificial heart inner wall anticoagulation surface, an artificial heart-lung machine anticoagulation surface and the like.

Description

technical field [0001] The invention relates to the technical field of biomaterials, and in particular to anticoagulation and a material with biological antifouling function, its preparation method and application. Background technique [0002] Pulmonary embolism is a disease with a high clinical mortality rate. Although the current systemic anticoagulant therapy can achieve a certain effect, it still cannot completely avoid the occurrence of pulmonary embolism, and systemic anticoagulant therapy itself will have complications, and some patients Unable to accept systemic anticoagulant therapy. As a preventive method for pulmonary embolism, inferior vena cava filter has been widely used all over the world. With the widespread clinical use, some corresponding complications also appeared, which made the filter treatment fail and even lead to the death of the patient. [0003] During the implantation of the inferior vena cava filter, the surgical operation will cause damage to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L27/34A61L33/00A61L33/06A61L33/08A61L27/54A61L31/16
CPCA61L27/34A61L27/54A61L31/10A61L31/16A61L33/0029A61L33/068A61L33/08A61L2300/216A61L2300/236A61L2300/42A61L2300/608A61L2400/18A61L2420/08A61L2430/20C08L101/025C08L5/08
Inventor 黄楠杨作霞钟永英
Owner CHENGDU JIAODA MEDICAL SCI & TECH COMPANY
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