Preparation and application of hyperbranched aminated porous microspheres
A technology of porous microspheres and microspheres, which is applied in the preparation of microspheres, microcapsules, and sugar derivatives. It can solve the problems of insufficient separation specificity of active compounds, and achieve cheap raw materials, controllable reactions, and simple processes. Effect
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[0032] The invention relates to a method for preparing hyperbranched aminated porous microspheres. The hyperbranched aminated porous microspheres include polyethyleneimine, double emulsion polymer and porous microspheres. The surface of the hyperbranched aminated porous microspheres contains a large amount of polyethylene Imine, the size of the microsphere is about 4 μm, and the hyperbranched aminated porous microsphere introduces polyethyleneimine into the porous microsphere at the same time of double emulsion polymerization.
[0033] The preparation method of PGMA-PAM@PEI is as follows:
[0034] Step1: Take 0.1mL of 1-chlorotridecane, sodium dodecyl sulfate (SDS) (0.25% w / w) and 20mL of SDS (0.25% w / w);
[0035] Step2: Add 0.1 mL of 1-chlorotridecane to sodium dodecyl sulfate (SDS) (0.25% w / w) to form 10 mL of emulsion;
[0036] Step3: Mix the emulsion obtained above with 20mL SDS (0.25% w / w) containing 200 mg sulfonated polystyrene (SPS) microspheres to obtain a mixed...
Embodiment 1
[0049] Prepare PGMA-PAM@PEI-1. The particle size of the microsphere is 4 μm. The microsphere is polymerized from GMA, DVB and AM. PEI is introduced while polymerizing the microsphere. The preparation method of the microsphere is as follows:
[0050] Step 1. Add 0.1 mL of 1-chlorotridecane to SDS (0.25% w / w) to form 10 mL emulsion and mix with 20 mL SDS (0.25% w / w) were mixed, and the mixed solution was stirred at 40 °C for 20 h.
[0051] Step 2. Prepare 10 mL emulsion in SDS aqueous solution (0.25% w / w), which is composed of 1 mL divinylbenzene (DVB), 519 mg acrylamide (AM), 1 mL glycidyl methacrylate (GMA) and 40 mg 2,2'-Azoisobutyronitrile (AIBN) composition. It was quickly added to the above mixed solution, and the mixed solution was stirred at 40 °C for another 3 h. Then, 2 g of PEI was added to the above mixture.
[0052] Step 3. Add 5 mL of polyvinyl alcohol (PVA) aqueous solution (1% w / w) to the above solution, and protect the mixture with nitrogen gas. At the sam...
Embodiment 2
[0056] To prepare PGMA-PAM@PEI-2, the difference compared with PGMA-PAM@PEI-1 in Example 1 is: in step 2, the PEI weighing 2 g is changed to the PEI weighing 3 g; finally Microspheres with a particle size of 4 μm were obtained.
[0057] figure 2 It is a transmission electron microscope image of PGMA-PAM@PEI-2 prepared in Example 2.
[0058] Under the adsorption condition of 30°C, PGMA-PAM@PEI-2 was used to separate and purify verbascoside from Cistanche tubulosa. The adsorption capacity of verbascoside was 76.5, and the selectivity was 4.4.
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