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Toothpaste containing composite biological enzyme preparation and having multiple whitening effects and preparation method thereof

A technology of compound biological enzymes and preparations, applied in the field of daily chemical products, can solve the problems of tooth tissue wear, unsuitable for long-term use, and it is recommended that the use time should not exceed 4 weeks, so as to reduce high friction, remove dental calculus and exogenous teeth. Pigmentation, reduce the effect of the regeneration process

Inactive Publication Date: 2021-04-30
上海绿瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, whitening toothpaste (RDA>100) containing high cleaning abrasives will also cause a certain degree of tooth tissue wear and tear, so it is not suitable for long-term use. It is recommended not to use it for more than 4 weeks to ensure the safety of enamel and dentin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] This embodiment is a kind of water formula toothpaste with multiple whitening effects containing compound biological enzyme preparation, toothpaste comprises the following components by weight percentage: glycerin 3%, thickener 1%, sorbitol (sugar) alcohol 40% , sweetener 0.1%, anti-caries agent 0.32%, bromelain 0.001%, papain 0.001%, lysozyme 0.01%, polyphosphate 5%, pyrophosphate 0.1%, preservative 0.1%, abrasive 30% , foaming agent 2.5%, alkaline pH value regulator 0.6%, acidic pH value regulator 1.3%, essence 0.8% and the rest are water.

[0062] The weight ratio of lysozyme to the total mass of two proteases, bromelain and papain, is 1:0.2.

[0063] Among the above components, the thickener is selected from cellulose gum. Sweetener is selected xylitol for use. The anti-caries agent is sodium monofluorophosphate. The preservative is selected from methylparaben. Pyrophosphate is selected tetrapotassium pyrophosphate for use. Polyphosphate is selected sodium trip...

Embodiment 2

[0071] The present embodiment is a water-based formula toothpaste with multiple whitening effects containing compound biological enzyme preparations. The toothpaste includes the following components by weight percentage: 3% glycerin, 1% carrageenan, 40% sorbitol, Sucralose 0.1%, Sodium Fluoride 0.32%, Bromelain 0.05%, Papain 0.05%, Lysozyme 0.2%, Polyphosphate 5%, Pyrophosphate 0.1%, Preservative 0.1%, Hydrated Silica 30%, Sodium lauryl sulfate 1.5%, cocamidopropyl betaine 1%, sodium hydroxide aqueous solution 0.6%, disodium citrate anhydrous 1.3%, essence 0.8% and the rest is water.

[0072] The weight ratio of lysozyme to the total mass of two proteases, bromelain and papain, is 2:1.

[0073] The above water-based formula toothpaste containing complex biological enzyme preparations with multiple whitening effects can be prepared by the method in Example 1. The toothpaste had a final test pH of 7.2.

Embodiment 3

[0075] This embodiment is a kind of water formula toothpaste with multiple whitening effects containing compound biological enzyme preparation. The toothpaste comprises the following components by weight percentage: 3% glycerin, 1% cellulose gum, 40% sorbitol (sugar) alcohol , sweetener 0.1%, sodium monofluorophosphate 0.32%, bromelain 0.001%, papain 0.001%, lysozyme 0.01%, sodium tripolyphosphate 5%, tetrapotassium pyrophosphate 0.1%, methylparaben 0.1%, Hydrated silica 50%, sodium lauryl sulfate 1.5%, cocamidopropyl betaine 1%, 50% sodium hydroxide solution 0.2%, sodium citrate 1.8%, essence 0.8% and the rest is water.

[0076] The weight ratio of lysozyme to the total mass of two proteases, bromelain and papain, is 1:0.2.

[0077] The above water-based formula toothpaste containing complex biological enzyme preparations with multiple whitening effects can be prepared by the method in Example 1. The final test pH of the toothpaste was 5.6.

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Abstract

The invention provides toothpaste containing a composite biological enzyme preparation and having multiple whitening effects and a preparation method of the toothpaste. The toothpaste comprises the following components in percentage by weight: 1%-10% of glycerol, 0.1%-3.0% of a thickening agent, 40%-80% of sorbitol (sugar) alcohol, 0.1%-0.5% of a sweetening agent, 0.02%-1.0% of an anticaries agent, 0.001%-0.5% of bromelain, 0.001%-0.5% of papain, 0.01%-2% of lysozyme, 0.01%-5% of polyphosphate, 0.1%-10% of pyrophosphate, 0.1%-1% of a preservative, 5%-50% of a grinding agent, 0.3%-4.0% of a foaming agent, 0.8%-2.0% of essence, 0.1%-1.0% of an alkaline pH value regulator, 0.1%-2.0% of an acidic pH value regulator and the balance of water. The pH value of the formula is controlled to be 6.0-8.0, under the enzymatic action of papain, bromelain and lysozyme, protein films and bacterial biofilms on the surfaces of teeth are subjected to enzymolysis, exogenous stains on the teeth are effectively removed to achieve the effect of whitening the teeth, and the problem of exogenous stains on the teeth caused by long-term diet is solved.

Description

technical field [0001] The invention relates to the field of daily chemical products, in particular to an aqueous formula and anhydrous formula toothpaste with multiple whitening effects containing a compound biological enzyme preparation and a preparation method thereof. Background technique [0002] Toothpaste is a cleaning product commonly used in daily life for cleaning teeth and protecting oral hygiene. With the continuous development of science and technology, people's living standards are gradually improving, and correspondingly, the quality demand for toothpaste is also gradually increasing, and the function is also developing from a single cleaning type to a multifunctional type. [0003] More than half of consumers are concerned about yellowing and stained teeth, as this is considered a sign of poor oral hygiene or aging. Beyond basic needs (plaque removal and caries prevention), consumer demand for oral care products that have a positive effect on tooth surface w...

Claims

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Application Information

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IPC IPC(8): A61K8/66A61K8/19A61K8/20A61K8/24A61K8/25A61K8/34A61Q11/00
CPCA61K8/66A61K8/345A61K8/25A61K8/19A61K8/24A61K8/20A61Q11/00A61K2800/5922A61K2800/28
Inventor 姜春鹏李岗
Owner 上海绿瑞生物科技有限公司
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