A kind of aluminum magnesium carbonate granule and preparation method thereof
A technology of aluminum magnesium carbonate and granules, which is applied in the directions of aluminum/calcium/magnesium active ingredients, pharmaceutical formulations, medical preparations with non-active ingredients, etc. It can avoid the problems of patients with difficulty in taking it, and chewable tablets are not suitable for patients who have difficulty in chewing, so as to avoid the difference in the antacid performance of the drug in vitro, the maintenance time of the antacid in vitro, and the decrease of the stability of the drug.
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Embodiment 1
[0044] A hydrotalcite granule, in parts by weight, in every 1000 packs (2g / pack) of hydrotalcite granules, the content of each component is as follows:
[0045]
[0046] Preparation method: Weigh the prescription amount of aluminum magnesium carbonate (particle size distribution D(V, 0.9) is 50.5 μm, D(V, 0.5) is 17.9 μm), mannitol, corn starch, banana flavor, mint flavor, pass through 50 mesh Sieve, put it in a wet mixing granulator and mix evenly; prepare hydroxypropyl cellulose into an aqueous solution with a concentration of about 3.1%, and then add sodium saccharin to dissolve it to obtain a granulation solution, and then add the above mixture to the wet method The soft material is produced in the mixing granulator, and the prepared soft material is passed through a 14-mesh screen, dried in a boiling dryer at 50°C-53°C, and sieved with a vibrating sieve with a 10-mesh screen on the upper layer and a 60-mesh screen on the lower layer. Whole grains, mixed evenly, that is...
Embodiment 2
[0048] A hydrotalcite granule, in parts by weight, in every 1000 packs (2g / pack) of hydrotalcite granules, the content of each component is as follows:
[0049]
[0050]
[0051] Preparation method: Weigh the prescription amount of aluminum magnesium carbonate (particle size distribution D(V, 0.9) is 52.5 μm, D(V, 0.5) is 7.0 μm), mannitol, corn starch, banana flavor, mint flavor, pass through 50 mesh Sieve, put it in a wet mixing granulator and mix evenly; prepare hydroxypropyl cellulose into an aqueous solution with a concentration of about 1.7%, and then add sodium saccharin to dissolve it to obtain a granulation solution, and then add the above mixture to the wet method The soft material is produced in the mixing granulator, and the prepared soft material is passed through a 14-mesh sieve, and dried in a boiling dryer at 60°C. The upper layer of the vibrating sieve is equipped with a 10-mesh sieve, and the lower layer is equipped with a 60-mesh sieve. Mix well and se...
Embodiment 3
[0053] A hydrotalcite granule, in parts by weight, in every 1000 packs (2g / pack) of hydrotalcite granules, the content of each component is as follows:
[0054]
[0055] Preparation method: Weigh the prescription amount of aluminum magnesium carbonate (particle size distribution D (V, 0.9) is 52.5 μm, D (V, 0.5) is 7.0 μm), mannitol, and corn starch, pass through a 50-mesh sieve, and set wet method Mix evenly in a mixing granulator; prepare hydroxypropyl cellulose into an aqueous solution with a concentration of about 1.7%, then add sodium saccharin to dissolve it to obtain a granulation solution, and then add the above mixture to a wet mixing granulator to prepare Soft material, the prepared soft material is passed through a 14-mesh sieve, dried in a boiling dryer at 60°C, sieved with a vibrating sieve with a 10-mesh sieve on the upper layer and a 60-mesh sieve on the lower layer, and mixed evenly.
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Abstract
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