Magnetic field control spiral nano robot for targeted drug delivery

A nano-robot, magnetic nano-technology, applied in the nano field, to achieve the effect of low cost and strong operability

Inactive Publication Date: 2021-05-14
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, current carbon nanotube nanorobots for field-controlled targeted drug delivery remain to be investigated.

Method used

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  • Magnetic field control spiral nano robot for targeted drug delivery
  • Magnetic field control spiral nano robot for targeted drug delivery
  • Magnetic field control spiral nano robot for targeted drug delivery

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] Preparation method of helical nanorobot

[0048] In another aspect of the present invention, the present invention proposes a method for preparing a helical nanorobot. According to an embodiment of the present invention, the method includes: forming a polyethylene glycol modified layer on the helical carbon nanotube substrate; respectively connecting magnetic nano drug-loaded particles and target cell ligands on the polyethylene glycol modified layer to obtain helical nanotubes robot.

[0049] As mentioned above, the helical nanorobot prepared by this method can realize comprehensive functions such as single large-dose drug loading, cell-specific recognition and precise targeting, and field-controlled drug release.

[0050] Use of helical nanorobots in targeted drug delivery

[0051] In yet another aspect of the present invention, the present invention proposes the use of helical nanorobots in targeted drug delivery. According to an embodiment of the present inventio...

Embodiment 1

[0063] Quantum dots based on graphene materials, CoFe 2 o 4 -BaTiO 3 The magnetic nanoparticles of the material are taken as an example, and the anticancer drugs such as doxorubicin (DOX) and paclitaxel (PTX) are used as examples for carrying drugs. The target cell ligands are folic acid ligands, transferrin ligands and epithelial growth Taking the factor ligand as an example, the specific implementation process of the present invention is described.

[0064] Step 1: The helical carbon nanotubes are prepared in batches by using the existing chemical vapor deposition process, the size: the pitch is 480-520nm, the wire diameter is 230-260nm, and the outer diameter of the helix is ​​400-550nm. Use concentrated nitric acid to carry out oxidative treatment to the prepared helical carbon nanotubes, make its surface carboxylate, and obtain carboxylated helical carbon nanotubes (refer to figure 1 ).

[0065] Step 2: Combine carboxylated helical carbon nanotubes with an activator (...

Embodiment 2

[0071] Taking the helical nanorobot prepared in Example 1 (carrying anticancer drugs doxorubicin (DOX) and paclitaxel (PTX), the target cell ligand is selected to specifically recognize the folic acid ligand of human breast cancer cell MCF-7) as an example, In detail, the novel structure of the helical nanorobot of the present invention has significant advantages in targeted drug delivery and treatment, and the specific implementation steps are as follows:

[0072] Helical nanorobots use graphene quantum dot-modified helical carbon nanotubes as a substrate, modify polyethylene glycol to improve the biocompatibility of helical nanorobots, and attach magnetic nanoparticles to the surface for magnetization and drug delivery of helical nanorobots .

[0073] In a liquid (such as blood) environment outside the body, the helical nanorobot realizes controllable and efficient three-dimensional movement under the action of a rotating magnetic field (70Hz, 40Gs), and can be driven accord...

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Abstract

The invention provides a magnetic field control spiral nano-robot for targeted drug delivery. The nano-robot comprises a spiral carbon nanotube matrix, a polyethylene glycol modification layer, magnetic nano drug-loaded particles and a target cell ligand. The spiral nano robot can achieve multiple functions of magnetic field driving, drug carrying, targeted cell recognition, controllable drug release, fluorescence feedback and the like, lays a foundation for scientific research and clinical treatment of drug delivery, and has potential application prospects in the field of biomedicine.

Description

technical field [0001] The present invention relates to the field of nanotechnology. Specifically, the present invention relates to a magnetic field-controlled helical nanorobot for targeted drug delivery. Background technique [0002] A nanorobot is a composition that can convert energy in the form of chemical energy, electrical energy, magnetic energy, and light energy into kinetic energy or driving force of a nanostructure. It has the characteristics of small size and flexible movement, and can be controlled in a narrow space. movement to achieve a specific function or task. For example, by modifying functional substances, nanorobots can realize functions such as ion adsorption, pollution degradation, and repair of micro-nano parts. Nanorobots have broad application prospects in the field of biomedicine, and are expected to achieve precision medicine in disease diagnosis, drug delivery, and cancer treatment. [0003] According to the World Health Organization, cancer i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/04A61K47/10A61K47/22A61K41/00A61K45/00A61K31/704A61K31/337A61P35/00
CPCA61K9/5115A61K9/5146A61K9/5015A61K9/0009A61K41/00A61K45/00A61K31/704A61K31/337A61P35/00
Inventor 佟浩白学元林佳聪李勇侯冰洋
Owner TSINGHUA UNIV
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