Bioglass composite bone cement and electric field treatment method

A technology of biological glass and processing method, applied in the fields of pharmaceutical formulation, tissue regeneration, drug delivery, etc., can solve the problem of reduced release of active ions, and achieve the effect of improving electrical conductivity, improving efficiency, and promoting healing

Active Publication Date: 2022-04-05
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the middle and late stages after 1-2 weeks of use, the release of active ions in the bioglass is significantly reduced

Method used

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  • Bioglass composite bone cement and electric field treatment method
  • Bioglass composite bone cement and electric field treatment method
  • Bioglass composite bone cement and electric field treatment method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Change the basic chemical composition to 54SiO 2 -6Na 2 O-8K 2 O-8MgO-22CaO-2P 2 o 5(mol%) borosilicate biological glass powder is placed in the simulated body fluid (SBF) of the human body at 37 ℃ and applies a direct current electric field to carry out pretreatment, and the application time is 5h, and the electric current is 200mA, on the surface of the biological glass powder particles, a rich layer of diffusion channels is generated. Silica glass phase slow release film layer. Then, according to the mass number, take 50 parts of pretreated borosilicate biological glass powder, 40 parts of sodium alginate mixed solution, and 10 parts of titanium nitride nano-conductive functional phase with an average particle size of 400nm to make borosilicate The bioglass composite bone cement is soaked in human simulated body fluid (SBF) after curing, and kept in a constant temperature environment of 37°C. The concentration of active ions in the immersion solution was tested ...

Embodiment 2

[0039] According to the mass number, take 10 parts of the basic chemical composition as 54SiO 2 -6Na 2 O-8K 2 O-8MgO-22CaO-2P 2 o 5 (mol%) borosilicate biological glass powder and 90 parts of PMMA mixed solution are made into borosilicate biological glass composite bone cement, which is soaked in human simulated body fluid (SBF) after solidification and molding, and kept at a constant temperature of 37°C. After the 8th day, a DC electric field was applied to the human simulated body fluid containing bone cement for 1 hour every day, and the currents were 30mA, 60mA and 90mA respectively, and a control group without electric field was set up. For details on the surface morphology and calcium-phosphorus ratio of silicate bioglass particles, see figure 2 , it can be seen from the figure that with the increase of the loading current intensity, the hydroxyapatite particles precipitated on the surface of the borosilicate bioglass particles during the degradation process continu...

Embodiment 3

[0041] Change the basic chemical composition to 54SiO 2 -6Na 2 O-8K 2 O-8MgO-22CaO-2P 2 o 5 (mol%) borosilicate biological glass powder is placed in the human body simulated body fluid (SBF) of 45 ℃ and applies direct current electric field to carry out pretreatment, and application time is 3h, and electric current 300mA, generates the rich that contains diffusion channel on the biological glass powder particle surface Silica glass phase slow release film layer. Then, according to the mass number, 70 parts of pretreated borosilicate bioglass powder and 30 parts of sodium alginate mixed solution were taken to make borosilicate bioglass composite bone cement, which was soaked in human simulated body fluid ( In SBF), maintain a constant temperature environment of 37°C. Using an inductively coupled plasma emitter to test the concentration of active ions in the soaking solution, the release of boron ions and calcium ions on the first day of immersion in the bioglass composite ...

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Abstract

The invention relates to a bioglass composite bone cement and an electric field treatment method. The electric field treatment method includes applying a direct current electric field to borosilicate bioglass powder to induce surface pretreatment; it may also include curing the borosilicate bioglass composite bone cement. Then load a safe DC electric field. Compared with the prior art, in the present invention, the borosilicate biological glass powder induces surface pretreatment by a direct current electric field to generate a silicon-rich glass phase slow-release film layer containing diffusion channels to improve the bioglass composite bone cement made of it. Biosafety at the initial stage of use; after curing, the borosilicate bioglass composite bone cement regulates the biological activity of the bioglass composite bone cement by loading a safe DC electric field to achieve controllable and sustainable repair of bone tissue; in the bioglass composite bone cement The introduction of nano-conductive functional phase can improve the electrical conductivity of bioglass bone cement and improve the efficiency of DC electric field-induced mineralization; this technology can be applied to bone repair, regeneration and other fields in bone tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a bioglass composite bone cement and an electric field treatment method. Background technique [0002] In recent years, due to accidents such as traffic accidents, diseases, natural disasters and the aging of the population, bone diseases have become an important issue today. According to statistics, there are 3 million bone trauma patients in my country every year, and nearly 200 million osteoporosis patients and osteoarthritis patients every year. Bone tissue defects and injuries have become important diseases that affect people's health and life. Bioactive glass bone cement with borosilicate bioglass powder as solid phase is an emerging biomedical bone repair material with excellent biocompatibility, bioactivity and biodegradability. As a biomedical material, this kind of material has incomparable advantages over metals, polymers and biologically inert materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/02A61L27/54A61L27/04A61L27/50
CPCA61L27/10A61L27/025A61L27/54A61L27/047A61L27/50A61L2430/02A61L2300/602A61L2400/12A61L2300/102
Inventor 林健姚爱华朱子旻张敏慧张轩宇
Owner TONGJI UNIV
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