Method for preparing collagen substrate material for oral cavity by using biological bone

Abstract

The invention discloses a method for preparing a collagen substrate material for an oral cavity by using biological bone. The method comprises the steps of cutting young bovine bone or swine bone, then, carrying out treatments such as virus removing, defatting, deproteinization, decalcification, cell removing and endotoxin removing, then, carrying out freeze-drying, and then, shearing the bone into required specifications. The whole process is simple, the production cycle is short, and thus, large-scale mass production is facilitated. According to the method, the young bovine bone or swine bone is selected as a raw material and is rich in source, degradation-induced inflammatory reactions are reduced, and clearing is easy, so that immunological rejections caused after human body implantation are avoided. Moreover, the young bovine bone and swine bone materials have good porosity and pore size channels and are similar to human bones in porosity, a human body microenvironment is simulated, crawling passing of seed cells such as osteoblasts is facilitated, healing of soft tissue can be excellently promoted, and the osteogenesis capability is relatively good. Furthermore, chemical reagents of all treatment steps are spin-dried in a long running water state and washed off, the speed is high, and the washing is thorough and residual-free, so that the safety of use of the product is further guaranteed.

Description

technical field [0001] The invention relates to a method for preparing a collagen matrix material for oral cavity by using biological bone. Background technique [0002] During the medical treatment of oral diseases, when patients experience tooth discomfort in the oral cavity such as dental trauma, misplaced teeth, extra teeth, and retained deciduous teeth, tooth extraction surgery is often required. Immediately after tooth extraction, implant the filling material in the extraction socket, which can support and fill the alveolar socket, block or slow down the alveolar bone resorption, prevent the gingival epithelium or fibrous tissue from entering the extraction socket, and guide and promote the bone regeneration of the extraction socket to achieve Alveolar bone preservation or augmentation. [0003] At present, dental socket filling materials can be roughly divided into artificial synthetic materials and biological bone materials. Among them, there are problems with synt...

AI Technical Summary

Problems solved by technology

Among them, there are problems with synthetic materials: on the one hand, the degradation rate of synthetic materials in the human body is not easy to control, and it is out of sync with the bone regeneration and repair speed of periodontal tissue repair and tooth extraction socket; on the other hand, synthetic materials, such as polylactic acid Degradation products will cause strong acidity in the local environment, but will inhibit the repair and growth of the repaired tissue, so it is gradually replaced by biological bone materials

[0005] However, whether it is directly washed with clean water or shaken, it takes a long time, resulting in a long production cycle of the entire product, which is not conducive to large-scale mass production of products

Moreover, the current bio-bone materials contain many organic components such as miscellaneous proteins, cells, and antigens. If they are not completely removed, they will easily cause immune rejection after implantation in the human body, which will affect the healing of soft tissue in the extraction socket.

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