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Nanoreactor, preparation method and application thereof

A nano-reactor, nano-particle technology, applied in pharmaceutical formulations, metal processing equipment, medical preparations with non-active ingredients, etc., can solve the problems such as the inability to achieve controlled release of silver, and achieve low systemic toxicity and high safety. , The effect of preparation technology is simple

Active Publication Date: 2021-05-25
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, so far, on nanocarrier-based Ag + -Zn 2+ There are few antibacterial studies on co-delivery, and most of them are silver-zinc composite nanomaterials. For example, silver nanoparticles are attached to the surface of zinc oxide, and the controlled release of highly toxic silver cannot be achieved.

Method used

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  • Nanoreactor, preparation method and application thereof
  • Nanoreactor, preparation method and application thereof
  • Nanoreactor, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Preparation of Zeolite Imidazolate Framework-8(ZIF-8)1#

[0077] 0.89g Zn(NO 3 ) 2 ·6H 2 O was dissolved in 30 mL of methanol to form a solution. 20 mL of methanol containing 1.97 g of 2-methylimidazole was poured into Zn(NO 3 ) 2 in solution. The mixture was kept at room temperature for 24 hours. The resulting white precipitate was collected by centrifugation, washed three times with methanol, and finally placed in an oven at 60° C. to dry overnight.

[0078] Preparation of intermediate product A1

[0079] Dip sample 1# into 10mL methanol solution containing 40μmol metal silver ions, and stir evenly. Then 1 mL of methanolic solution containing 40 mg of sodium borohydride was added to the mixture with vigorous stirring. After reacting for 30 minutes, the product was collected by centrifugation, washed several times with ethanol, and dried overnight at 60°C to synthesize sample A1. The intermediate product A1 was nanoparticles loaded with metallic silver on ZIF-...

Embodiment 2

[0086] The zeolite imidazolate framework-8 (ZIF-8) used in this example is the sample 1# prepared in Example 1.

[0087] Preparation of intermediate product A2

[0088] Immerse sample 1# in 10mL of methanol solution containing 20μmol metal copper ions, and stir evenly. Then 1 mL of methanolic solution containing 10 mg of sodium borohydride was added to the mixture under vigorous stirring. After reacting for 30 minutes, the product was collected by centrifugation, washed several times with ethanol, and dried overnight at 60° C. to synthesize intermediate product A2.

[0089] Preparation of nanoreactor C2 (mesoporous)

[0090] 0.1 g of cetyltrimethylammonium bromide was dissolved in a mixture of water (20 mL) and ethanol (8 mL). Then, add ammonia solution (NH 4 OH, 0.2 mL, 25 wt%) and stirred at room temperature, then sample A2 was added. After stirring, 450 μL of ethyl orthosilicate solution was added to the suspension. The mixture was stirred at room temperature for 24 h...

Embodiment 3

[0094] The zeolite imidazolate framework-8 (ZIF-8) used in this example is the sample 1# prepared in Example 1.

[0095] Preparation of intermediate product A3

[0096] Dip sample 1# into 10mL methanol solution containing 40μmol metal silver ions, and stir evenly. Then 1 mL of methanolic solution containing 20 mg of sodium borohydride was added to the mixture under vigorous stirring. After reacting for 30 minutes, the product was collected by centrifugation, washed several times with ethanol, and dried overnight at 60° C. to synthesize intermediate product A3.

[0097] Preparation of nanoreactor C3 (mesoporous)

[0098] 0.5 g of cetyltrimethylammonium bromide was dissolved in a mixture of water (20 mL) and ethanol (8 mL). Then, add ammonia solution (NH 4 OH, 0.3mL, 25wt%) and stirred at room temperature, then added Ag&ZIF-8 nanoparticles. After stirring, 330 µL of ethyl orthosilicate solution was added to the suspension. The mixture was stirred at room temperature for 24...

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Abstract

The invention discloses a nanoreactor, a preparation method and an application thereof. The nanoreactor is metal-loaded hollow silicon dioxide nanoparticles; the metal comprises metal I and metal II; the metal I comprises any one of a silver element, a copper element, a cobalt element, a nickel element and a magnesium element; and the metal II is a zinc element. The nanoparticles obtained by adopting the preparation method disclosed by the invention have the advantages of uniform size, high surface area, ordered mesopores and large pore volume. In addition, the nanoreactor can also be used as an ideal antibacterial agent for treating MRSA infection.

Description

technical field [0001] The application relates to the technical field of inorganic nanomaterials, in particular to a nanoreactor, a preparation method and its application. Background technique [0002] Antimicrobial resistance (AMR) worldwide is leading to increased mortality and healthcare costs. In 2014, the World Health Organization (WHO) reported that in 5 of the 6 regions of the World Health Organization, the resistance rate of Escherichia coli to cephalosporins exceeded 50%, and the resistance rate of Staphylococcus aureus to methicillin was 50%. %. To prevent the development of resistance, antibiotics must address a wide range of resistance mechanisms, such as enzymatic degradation, efflux, and impermeability. A promising alternative to current antibiotics are inorganic nanoparticles, which are able to kill pathogens through various modes of action. First, the released metal ions can cause bacterial death; in addition to interfering with the metabolic system, heavy...

Claims

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Application Information

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IPC IPC(8): A61K33/38A61K9/52A61K47/04A61P31/04B22F9/24B22F1/02B22F1/00A61K33/30
CPCA61K33/38A61K33/30A61K9/5115A61P31/04B22F9/24B22F1/07B22F1/054B22F1/17A61K2300/00
Inventor 刘健刘利红刘少敏田昊王昕尧张绍昆陈艳平吴宏
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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