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A kind of electrostatic spraying film of hydrogel and its preparation method and application

An electrostatic spraying and hydrogel technology, applied in pharmaceutical formulations, prostheses, bandages, etc., can solve the problems of time-consuming, cumbersome preparation process, increase product production cost and risk management cost, etc., and achieve uniform thickness and simple production process. , the effect of simple use

Active Publication Date: 2022-07-29
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current research on hydrogels is too novelty-oriented, while ignoring the operability of product scale-up production and the convenience of application forms (dosage forms)
For example, a considerable amount of injectable hydrogel is composed of more than two components. If each component is temporarily dissolved before use, the preparation process is very cumbersome and time-consuming; if each component is dissolved in advance and filled into the syringe, These precursor solutions have very strict requirements on sterilization methods and storage conditions. For example, the high viscosity state limits the use of filter sterilization for sterilization, and the irradiation sterilization of the aqueous solution will affect the final product. Glue performance, and this product form generally requires cold chain transportation and low temperature storage, which invisibly increases the production cost and risk management cost of the product
In addition, when applying hydrogel materials on the surface of some regular-shaped materials, it is difficult to apply a hydrogel coating with uniform thickness due to the high viscosity of the hydrogel precursor solution.

Method used

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  • A kind of electrostatic spraying film of hydrogel and its preparation method and application
  • A kind of electrostatic spraying film of hydrogel and its preparation method and application
  • A kind of electrostatic spraying film of hydrogel and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation method of hydrogel electrostatic spraying film based on imine bond (1):

[0046] 1. Dosing

[0047] Solution A: According to the method described in Document 1, the dextran was aldehyde modified by the sodium periodate oxidation method, and the aldehyde dextran (O-DEX) was obtained after lyophilization. Then the O-DEX is dissolved in the acetic acid solution with a mass fraction of 20% according to the ratio of the material-to-liquid ratio of 4:10, and stirred until it is completely dissolved to obtain a uniform A liquid;

[0048] Liquid B: Aminated gelatin is obtained by ethylenediamine method according to the method described in Document 1, and then lyophilized to obtain aminated gelatin (N-GEL). Then, N-GEL was dissolved in an acetic acid solution with a mass fraction of 20% according to the ratio of the material to liquid ratio of 4:10, and stirred until it was completely dissolved to obtain a uniform B liquid.

[0049] 2. Electrostatic spraying

...

Embodiment 2

[0056] The preparation method of hydrogel electrostatic spraying film based on imine bond (2):

[0057] 1. Dosing

[0058] Liquid A: According to the method described in Document 2, sodium alginate is aldehyde-modified by sodium periodate oxidation method, and after freeze-drying, alginated sodium alginate (O-SA) is obtained. Then O-SA is dissolved in a hydrochloric acid solution with a mass fraction of 3% according to the ratio of the material-to-liquid ratio of 1:9, and stirred until it is completely dissolved to obtain a uniform A liquid;

[0059] Liquid B: Aminated carboxymethyl chitosan was grafted by ethylenediamine method according to the method described in document 3, and after freeze-drying, aminated carboxymethyl chitosan (N-CMCS) was obtained. Then, the N-CMCS was dissolved in a hydrochloric acid solution with a mass fraction of 3% according to the ratio of the material to liquid ratio of 1:9, and stirred until it was completely dissolved to obtain a uniform B liq...

Embodiment 3

[0067] The preparation method of hydrogel electrostatic spraying film based on imine bond (3):

[0068] 1. Dosing

[0069] Liquid A: According to the method described in Document 1, the dextran described in the document was replaced with hyaluronic acid, and the hyaluronic acid was aldehyde modified by the sodium periodate oxidation method, and the aldehyde group was obtained after lyophilization. hyaluronic acid (O-HA). Then, the O-HA is dissolved in a formic acid solution with a mass fraction of 6% according to the ratio of the material-to-liquid ratio of 1:5, and stirred until it is completely dissolved to obtain a uniform A liquid;

[0070] Liquid B: Dissolve the amine-terminated polyethylene glycol in a formic acid solution with a mass fraction of 6% in a ratio of 1:5, and stir until completely dissolved to obtain a uniform liquid B.

[0071] 2. Electrostatic spraying

[0072] The electrostatic spraying operation is carried out by using an electrostatic spinning machin...

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Abstract

The present invention relates to a hydrogel electrostatic spray film and its preparation method and application. The method includes: using the precursor A solution and the precursor B solution for forming a pH-responsive dynamic chemical bond as raw materials, and performing electrospinning or electrostatic spraying on the same film. The method of using the electrostatic spraying film is simple, and the electrospraying film can be quickly transformed into a hydrogel when it encounters water, and there is no need to use special accessories to mix the multi-component precursor solution.

Description

technical field [0001] The invention belongs to the field of biomedical materials and their preparation and application, in particular to a hydrogel electrostatic spray film and a preparation method and application thereof. Background technique [0002] Hydrogels are hydrophilic polymer networks formed by a variety of natural or synthetic polymer materials through physical interactions (such as hydrogen bonding, electrostatic interaction) or chemical reactions (such as Schiff base reaction, Michael addition reaction). Due to their good biocompatibility and diversity of synthetic mechanisms, in recent years, hydrogel materials have been designed as smart materials that respond to external stimuli such as light, heat, pH, magnetism, and redox. The fields of tissue engineering scaffolds, wound hemostatic closure materials, and cell therapy carriers have been widely studied and reported, and the formulation of injectable hydrogels is particularly attractive. This is because the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J5/18C08J3/075A61L31/04A61L31/14A61L31/16A61L31/12A61L27/26A61L27/54A61L27/52A61L27/40A61L15/22A61L15/44C08L89/00C08L5/08C08L5/04C08L71/02C08L67/04
CPCC08J5/18C08J3/075A61L31/041A61L31/145A61L31/16A61L27/26A61L27/54A61L27/52A61L15/225A61L15/44C08J2389/00C08J2305/08C08J2405/04C08J2371/02C08J2405/08C08J2367/04C08J2471/02A61L2400/04A61L2300/412C08L89/00C08L5/08C08L5/04C08L71/02C08L67/04
Inventor 莫秀梅李东升何创龙吴晶磊
Owner DONGHUA UNIV