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A method for rapid synthesis of highly fluorescent sulfur quantum dots

A sulfur quantum and fluorescent technology, applied in the field of nanomaterials, can solve the problems of cumbersome operation steps, low fluorescence quantum yield, and long time-consuming sulfur quantum dots, etc., and achieve the effects of broad application prospects, good light stability, and high yield

Active Publication Date: 2022-03-29
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Based on the defects existing in the prior art, the object of the present invention is to provide a preparation method and application of sulfur quantum dots. The raw materials of the preparation method are easy to obtain, the price is low, and the preparation method is simple, which can solve the problem of the preparation of sulfur quantum dots in the prior art. The time is long, the operation steps are loaded down with trivial details, the problems such as low fluorescent quantum yield; The advantage of the present invention is to provide green economy, fast preparation, easy operation, high fluorescent quantum yield and has wide application potential

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  • A method for rapid synthesis of highly fluorescent sulfur quantum dots
  • A method for rapid synthesis of highly fluorescent sulfur quantum dots
  • A method for rapid synthesis of highly fluorescent sulfur quantum dots

Examples

Experimental program
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Embodiment 1

[0033] At room temperature, 1g sulfur powder, 5g Na 2 S and 0.1g BSA, 50mL H 2 O is placed in a round-bottomed flask and ultrasonically treated for 10 min;

[0034] (2) Set the reaction temperature to 90° C., and the reaction time to 5 hours. After the reaction, cool down to room temperature naturally.

[0035] (3) Perform centrifugation and take the supernatant. In order to obtain pure sulfur quantum dots with uniform size distribution and removal of impurities such as unreacted raw materials, the centrifuged supernatant is filtered through a microporous membrane three times or placed in a dialysis bag for dialysis. The filtrate or dialysate is placed in a vacuum drying oven, heated, concentrated and dried. The obtained solid sulfur quantum dots are soluble in water and other solvents to meet the needs of different applications.

[0036] figure 1 TEM micrograph of the sulfur quantum dots prepared in Example 1. Depend on figure 1 It can be seen that the sulfur quantum do...

Embodiment 2

[0042] The sulfur quantum dots prepared in Example 1 were subjected to surface modification treatment. The specific method is:

[0043] At room temperature, 100 μL of hydrazine hydrate was added to 20 mL of sulfur quantum dot solution, and the reaction was stirred for 1 hour. The optical properties of the obtained surface-modified sulfur quantum dots were characterized, which proved to have the ability of biological imaging.

[0044] The modified sulfur quantum dots are used for cell fluorescence imaging. Due to their high fluorescence quantum yield and good biocompatibility, they show relatively bright fluorescence signals in cells.

Embodiment 3

[0046] The sulfur quantum dots prepared in Example 1 were subjected to surface modification treatment. The specific method is:

[0047] At room temperature, 10 μL of 0.1 M glucose oxidase (GOx) was added to 20 mL of the sulfur quantum dot solution, and the reaction was stirred for 1 h, and the obtained sulfur quantum dots were used for tumor treatment.

[0048] Loaded GOx can consume glucose in the body to produce H 2 o 2 , which has the effect of starvation healing.

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Abstract

The invention provides a method for rapidly synthesizing strong fluorescent sulfur quantum dots. The preparation method includes: adding sulfur powder and metal sulfide into a dispersion system to obtain a dispersion; the dispersion system includes protein and water; feeding an oxidizing gas into the system, and performing a stirring reaction under heating conditions; and finishing the reaction After cooling to room temperature and purification by centrifugation, filtration and dialysis, sulfur quantum dots were obtained. The method for preparing sulfur quantum dots by oxidizing gas oxidation in the present invention has the advantages of short reaction time, high fluorescence quantum yield, abundant surface functional groups, relatively uniform particle size distribution, good water solubility and biocompatibility, and high stability. The field has great application potential and significance.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and relates to a synthesis method for preparing strong fluorescent sulfur quantum dots by utilizing oxidative gas oxidation and protein passivation. Background technique [0002] Sulfur quantum dots are a kind of spherical fluorescent sulfur nanoparticles dispersed in nanometer scale. Sulfur quantum dots prepared by using sulfur powder and protein exhibit good chemiluminescent properties such as high fluorescence intensity, high photostability, anti-photobleaching, and low toxicity, which can be used in various fields such as detection, catalysis, imaging, and treatment. [0003] At present, cheap and easy-to-obtain, green and environmentally friendly synthetic raw materials, simple and rapid preparation methods, high quantum yield and red / near-infrared luminescent sulfur quantum dots need to be further developed and researched. However, so far, there have been only a few studies on ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/56C09K11/02B82Y20/00B82Y40/00G01N21/64C01B17/027C01B17/06A61K38/44A61K41/00A61K47/55A61K47/64A61K49/00A61P35/00
CPCC09K11/56C09K11/025B82Y20/00B82Y40/00G01N21/643C01B17/027C01B17/06A61K49/0067A61K38/443A61K47/64A61K47/55A61K41/0052C12Y101/03004A61P35/00G01N2021/6432
Inventor 蓝敏焕李香草赵少静
Owner CENT SOUTH UNIV
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