Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Oral sustained-release gel for treating candidiasis and preparation method of oral sustained-release gel

A slow-release gel and gel technology, applied in the direction of antifungal agents, local antibacterial agents, medical preparations of non-active ingredients, etc., can solve the problems of side effects and toxic side effects of patients, and improve solubility and action time Long-lasting, high-viscosity effect

Active Publication Date: 2021-06-25
ZHEJIANG UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing problem is that oral preparations or intravenous injection preparations are mostly administered systemically, because these drugs generally have certain toxic and side effects, and patients are susceptible to serious side effects when they are administered systemically for a long time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral sustained-release gel for treating candidiasis and preparation method of oral sustained-release gel
  • Oral sustained-release gel for treating candidiasis and preparation method of oral sustained-release gel
  • Oral sustained-release gel for treating candidiasis and preparation method of oral sustained-release gel

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] Preparation of liposomes

[0029] Take carboxymethyl cellulose, and through the method of superfine pulverization, carboxymethyl cellulose is pulverized into nano-scale particles, the average particle diameter is between 50-80nm, then take 10g of pulverized carboxymethyl cellulose, add Dissolved in ethanol, it was observed that carboxymethyl cellulose was completely dissolved without precipitation, and carboxymethyl cellulose alcohol solution was obtained.

[0030] Take 10 g of miconazole, add ethanol to dissolve, observe that miconazole is completely dissolved, no precipitation occurs, and a miconazole alcohol solution is obtained.

[0031] Mix the carboxymethyl cellulose alcohol solution and the miconazole alcohol solution to obtain a uniform solution, add lecithin under the condition of heating in a water bath at 50 degrees Celsius, stir to dissolve it, and form a clear solution.

[0032] Then slowly add the above-mentioned clear solution into the phosphate buffer s...

Embodiment 1

[0038] First take 20ml of liposome solution and 10ml of 3% sodium bicarbonate solution, stir and mix evenly, then add 30ml of 0.5% sodium hyaluronate solution, stir and mix evenly. The stirring temperature in the above process is 60 degrees Celsius, the stirring speed is 70r / min, and the vacuum degree is -0.02Mpa. Then add 5ml of 5% sodium hyaluronate gel, and stir evenly at a stirring speed of 30r / min, a temperature of 60 degrees Celsius and a vacuum of -0.02Mpa. Finally a gel formulation is obtained.

Embodiment 2

[0040] First take 25ml of liposome solution and 15ml of 3% sodium bicarbonate solution, stir and mix evenly, then add 35ml of 0.5% sodium hyaluronate solution, stir and mix evenly. The stirring temperature in the above process is 60 degrees Celsius, the stirring speed is 70r / min, and the vacuum degree is -0.02Mpa. Then add 5ml of 5% sodium hyaluronate gel, and stir evenly at a stirring speed of 30r / min, a temperature of 60 degrees Celsius and a vacuum of -0.02Mpa. Finally a gel formulation is obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides an oral sustained-release gel for treating candida mycoderma and a preparation method thereof, belongs to the field of pharmaceutical preparations, and solves the problems that patients are susceptible to serious side effects and the like due to the adoption of a systemic administration mode for a long time in the prior art. The oral sustained-release gel for treating the candida mycoderma is characterized by comprising the following raw materials in parts by volume: 20-30 parts of liposome, 30-45 parts of a gel material, 10-20 parts of a sodium bicarbonate solution with the concentration of 1%-4% and 5-8 parts of a molding material, and miconazole and carboxymethyl cellulose are encapsulated in the liposome. The invention has the advantages of local administration, long acting time and the like.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an oral sustained-release gel for treating candidiasis and a preparation method thereof. Background technique [0002] Candidiasis is a fungal disease caused by Candida species, especially Candida albicans. The pathogen can invade the skin and mucous membranes as well as viscera. Usually classified by site of involvement, the two most common syndromes are mucocutaneous candidiasis (eg, oropharyngeal candidiasis or thrush, esophagitis, and vaginitis) and invasive or deep organ candidiasis (eg, candidiasis syndrome, chronic disseminated or hepatosplenic candidiasis, endocarditis, etc.). [0003] For oropharyngeal candidiasis, Candida albicans stomatitis is common in the tongue, soft palate, buccal mucosa, gums, etc., and the existing treatment of oropharyngeal candidiasis mostly uses antibiotics to make oral preparations or intravenous injection preparations, etc., so a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/02A61K47/36A61K47/38A61K31/4174A61P1/02A61P31/10A61P31/02
CPCA61K9/06A61K47/02A61K47/36A61K47/38A61K31/4174A61P1/02A61P31/10A61P31/02Y02A50/30
Inventor 吴圣洁
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com