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Photoelectric biochemical sensor based on organic thin film field effect transistor as well as preparation method and application of photoelectric biochemical sensor

A field effect transistor and biochemical technology, applied in the field of biosensing, can solve the problems of cumbersome operation, increase the consumption of financial and material resources, etc., achieve good light response characteristics, reduce the consumption of financial resources and material resources, and good biocompatibility.

Active Publication Date: 2021-06-25
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in terms of improving the responsivity and sensitivity, some more complex strategies are generally adopted, including the synthesis of new organic semiconductor materials containing functional groups, device structure optimization and chemical modification, etc. However, these strategies are cumbersome to operate and greatly increase the consumption of financial and material resources.

Method used

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  • Photoelectric biochemical sensor based on organic thin film field effect transistor as well as preparation method and application of photoelectric biochemical sensor
  • Photoelectric biochemical sensor based on organic thin film field effect transistor as well as preparation method and application of photoelectric biochemical sensor
  • Photoelectric biochemical sensor based on organic thin film field effect transistor as well as preparation method and application of photoelectric biochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] like figure 1 Shown, a kind of photobiochemical sensor based on organic thin film field effect transistor, comprises: substrate, source electrode, drain electrode and organic semiconductor thin film, the substrate is the nitrogen-doped silicon substrate of 300nm silicon dioxide layer, organic semiconductor thin film is covered in On the substrate, a source electrode and a drain electrode are arranged between the organic semiconductor film and the substrate, the source electrode and the drain electrode are arranged in parallel, the source electrode and the drain electrode are made of gold, and the thickness is 30nm. Bulk type (D-A) organic polymer photoelectric active material, containing long alkyl chain D-A type organic polymer photoelectric active material is organic copolymer PDBT-co-TT, the absorption band of the organic semiconductor film is at 600-1000nm. The thickness of the organic semiconductor thin film was 40.73 nm.

[0063] The preparation method of organic...

Embodiment 2

[0065] The preparation method of photoelectric biochemical sensor in embodiment 1, comprises the following steps:

[0066] 1) Under an oxygen environment, treat the substrate with plasma for 10 minutes, then drop a silane coupling agent on the substrate, and keep it in a vacuum box at 120°C for 2 hours, wherein the silane coupling agent is octadecyltrichlorosilane ( OTS), every 1cm 2 Add 0.5 μL of silane coupling agent dropwise to the substrate, realize an oxygen environment through an oxygen flow of 20 sccm, and the rf power of the plasma is 100W;

[0067] 2) Paste a mask plate on the substrate obtained in step 1), then vapor-deposit a gold layer, remove the mask plate, form a source electrode and a drain electrode, and the W / L (width-to-length ratio) of the mask plate is 8;

[0068] 3) Spin-coat PDBT-co-TT, an organic polymer photoactive material containing long alkyl chain donor-acceptor type (D-A) organic polymer, on the substrate, at a spin-coating speed of 1500rpm, for ...

Embodiment 3

[0082] Because liver cancer is a common malignant tumor in my country, the mortality rate is increasing year by year, so the early diagnosis and treatment of liver cancer is particularly important. Alpha-fetoprotein antigen is the most specific disease marker and the main indicator for the diagnosis of liver cancer. Based on Example 3, the application of the photoelectric biochemical sensor of the present invention to the diagnosis of liver cancer is discussed.

[0083] Example 3

[0084] The application of photoelectric biochemical sensors in the detection of disease markers in embodiment 1, the method for detecting disease markers includes:

[0085] Step ①, drop 20 μL of probe solution on the photoelectric biochemical sensor, incubate at room temperature 20-25 °C for 1 h, wash the surface of the photo-biochemical sensor with 0.01×PBS for 3 times, dry at room temperature 20-25 °C for 2 seconds, and store in the dark. Test the I-t curve of the photoelectric biochemical senso...

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Abstract

The invention discloses a photoelectric biochemical sensor based on an organic thin film field effect transistor and a preparation method and application of the photoelectric biochemical sensor. The photoelectric biochemical sensor comprises a substrate, a source electrode, a drain electrode and an organic semiconductor thin film, wherein the organic semiconductor thin film covers the substrate; the source electrode and the drain electrode are arranged between the organic semiconductor film and the substrate, and the source electrode and the drain electrode are arranged in parallel; the organic semiconductor film is made of a photoelectric active material containing a long-alkyl-chain donor-acceptor type organic polymer; and an absorption band of the organic semiconductor film is located in a visible light region and / or an infrared light region. According to the invention, the responsivity and sensitivity of the photoelectric biochemical sensor to disease markers can be further improved, and early diagnosis and treatment of diseases are facilitated.

Description

technical field [0001] The invention belongs to the technical field of biosensing, and in particular relates to a photoelectric biochemical sensor based on an organic thin film field-effect transistor and a preparation method and application thereof. Background technique [0002] In recent years, biochemical sensors based on organic thin film field effect transistors have shown good application prospects in disease diagnosis as an emerging detection technology, because of their advantages such as simple structure, high flexibility, good biocompatibility, and label-free. It can meet the needs of fast, simple, cheap and label-free detection. Early detection and early treatment of diseases can significantly improve the specificity of treatment and the survival rate of patients. Currently, in clinical diagnosis, detection of disease markers is recognized as an effective method for diagnosing diseases. In order to achieve early detection, early intervention and early treatment o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01L51/42H01L51/00G01N33/574G01N33/543C12Q1/6825H10K99/00
CPCC12Q1/6825G01N33/5438G01N33/57438G01N33/57476G01N2333/471H10K71/10H10K30/354H10K30/65C12Q2565/607Y02E10/549
Inventor 程姗姗姜晓倩
Owner TIANJIN UNIV
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