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Sinapic acid-polydopamine composite broad-spectrum light screening agent as well as preparation method and application thereof

A technology of polydopamine and sinapinic acid, applied in the field of fine chemicals, to achieve the effect of solving the problems of easy agglomeration, poor photostability and high-efficiency light shielding agent performance

Active Publication Date: 2021-07-02
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the technical problems of existing light-shielding agents, the present invention proposes a kind of sinapinic acid-polydopamine composite broad-spectrum light-shielding agent and its preparation method and application

Method used

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  • Sinapic acid-polydopamine composite broad-spectrum light screening agent as well as preparation method and application thereof
  • Sinapic acid-polydopamine composite broad-spectrum light screening agent as well as preparation method and application thereof
  • Sinapic acid-polydopamine composite broad-spectrum light screening agent as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0035] A kind of preparation method of sinapinic acid-polydopamine composite broad-spectrum light shielding agent of the present embodiment, the steps are as follows:

[0036] (1) Synthesis of photostable plant sunscreen chitosan sinapinate:

[0037] Dissolve 0.5 g of chitosan in 50 mL of aqueous acetic acid (1%, v / v ), stirring and dissolving to a transparent homogeneous phase; adding 1.0 g vitamin C and 1.0 g sinapinic acid, and bubbling nitrogen gas for 30 minutes to remove oxygen in the reaction system; then adding 1.0 mL of H 2 o 2 Start the reaction, and react at room temperature for 16 hours under nitrogen protection; after the reaction, dialyze the reaction solution for 72 hours (dialysis bag: 10000 Da), concentrate the reaction solution in vacuo, and freeze-dry to obtain chitosan sinapinate.

[0038] figure 1 It is the H NMR spectrum of chitosan, sinapinic acid and chitosan sinapinate. Compared with the chitosan hydrogen spectrum, the synthesized chitosan sinapi...

Embodiment 2

[0043] A kind of preparation method of sinapinic acid-polydopamine composite broad-spectrum light shielding agent of the present embodiment, the steps are as follows:

[0044] (1) Synthesis of photostable plant sunscreen chitosan sinapinate:

[0045] Dissolve 2.0 g of chitosan in 200 mL of acetic acid aqueous solution (1%, v / v), stir and dissolve to a transparent homogeneous phase; add 1.0 g of vitamin C and 2 g of sinapinic acid, and bubble with nitrogen for 90 min to clear the reaction Oxygen in the system; then add 2.5 mL of H 2 o 2 Start the reaction and react at room temperature for 16 h under the protection of nitrogen; after the reaction, the reaction solution was dialyzed for 72 h (dialysis bag: 10000 Da), the reaction solution was concentrated in vacuo, and freeze-dried to obtain chitosan sinapinate.

[0046] (2) Preparation of sinapinic acid-polydopamine composite broad-spectrum light shielding agent:

[0047] Dissolve 100 mg chitosan sinapinate in 10 mL, 10 mmol / ...

Embodiment 3

[0049] A kind of preparation method of sinapinic acid-polydopamine composite broad-spectrum light shielding agent of the present embodiment, the steps are as follows:

[0050] (1) Synthesis of photostable plant sunscreen chitosan sinapinate:

[0051] Dissolve 1 g of chitosan in 150 mL of acetic acid aqueous solution (1%, v / v), stir and dissolve to a transparent homogeneous phase; add 1.0 g of vitamin C and 1.2 g of sinapinic acid, and bubble the reaction system with nitrogen for 60 min Oxygen in ; then add 1.5mL of H 2 o 2 Start the reaction and react at room temperature for 12 h under the protection of nitrogen; after the reaction, the reaction solution was dialyzed for 72 h (dialysis bag: 10000 Da), the reaction solution was concentrated in vacuo, and freeze-dried to obtain chitosan sinapinate.

[0052] (2) Preparation of sinapinic acid-polydopamine composite broad-spectrum light shielding agent:

[0053] Dissolve 500 mg chitosan sinapinate in 50 mL, 10 mmol / L tris-hydroc...

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Abstract

The invention belongs to the field of fine chemicals, and particularly relates to a sinapic acid-polydopamine composite broad-spectrum light screening agent as well as a preparation method and application thereof. In a system of vitamin C and hydrogen peroxide, sinapic acid is grafted to a chitosan polymer chain through a free radical-initiated grafting method, and the plant sun-screening agent chitosan sinalate with excellent light stability is obtained through dialysis and freeze drying. Chitosan sinalate is dissolved in a trihydroxymethyl aminomethane-hydrochloric acid buffer solution (pH=8.5), a certain amount of dopamine hydrochloride is added, a plant sun-screening agent and melanoids are organically combined through Michael addition of polydopamine and chitosan, and the sinapic acid-polydopamine composite broad-spectrum light screening agent is obtained. The screening agent has excellent light stability, broad-spectrum light shielding property and skin adhesion, has higher UVB and UVA protection capability compared with commercially available organic sunscreen agents, and has application prospects in sunscreen cream.

Description

technical field [0001] The invention belongs to the field of fine chemicals, and relates to a light shielding agent, in particular to a sinapinic acid-polydopamine composite broad-spectrum light shielding agent and its preparation method and application. Background technique [0002] With the understanding of the severity of skin photodamage, the use of sunscreens has been widely promoted. In recent years, more and more studies have found the negative impact of sunscreens on the ecological environment. Finding sunscreens from nature is an effective way to solve the plight of the sunscreen industry. [0003] As the main body of photosynthesis, plants also have a photoprotective mechanism. Studies have found that plants synthesize and deposit phenolic compounds that can absorb ultraviolet rays in epidermal tissue through the phenylpropanoid pathway to prevent excessive light. Malate sinapinate is a UV-shielding molecule used by cruciferous plants (Plant Cell, 1992, 4, 1413)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G73/06C08B37/08A61K8/84A61Q17/04
CPCC08G81/00C08G73/0672C08B37/003A61K8/84A61Q17/04A61K2800/84
Inventor 陈亚芍李妮妮冀晓虹
Owner SHAANXI NORMAL UNIV
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