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Fluorocytosine tablet and preparation method thereof

The technology of flucytosine tablet and flucytosine agent is applied in the field of medicine to achieve the effects of improving treatment effect, avoiding intestinal bleeding and avoiding double infection

Active Publication Date: 2021-07-09
药大制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing flucytosine products are generally capsules, injections, and tablets. Because fungi are prone to develop resistance to flucytosine, fungal drug resistance can be found in a long course of treatment, and drug resistance occurs frequently in this way. Monotherapy with flucytosine has limitations

Method used

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  • Fluorocytosine tablet and preparation method thereof
  • Fluorocytosine tablet and preparation method thereof
  • Fluorocytosine tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of flucytosine tablet, its preparation method comprises the following steps:

[0026] (1) Pass flucytosine, maltodextrin, sodium carboxymethyl starch, lactulose, and hypromellose through a 80-100 mesh sieve, aztreonam, pea flour, rice bran, brewer's yeast, and compound probiotics The agent is crushed separately and passed through a 200-230 mesh sieve;

[0027] (2) Mix 4.7g of aztreonam, 14g of pea powder, 10g of rice bran, 6g of brewer’s yeast and 3g of compound probiotics, add them to 57g of pure water, stir well and disperse evenly, and pass through a fluidization at a temperature of 50-55°C The bed is dried and crushed at 80-100 mesh to obtain mixture A;

[0028] (3) After mixing 31.2g of flucytosine, 20g of maltodextrin and 3g of lactulose, add it to 163g of pure water, fully stir and disperse evenly, then add 3g of sodium carboxymethyl starch, stir and disperse evenly, Obtain suspension B;

[0029] (4) Spray the mixture A into the suspension B under stirr...

Embodiment 2

[0032] A kind of flucytosine tablet, its preparation method comprises the following steps:

[0033] (1) Pass flucytosine, maltodextrin, sodium carboxymethyl starch, lactulose, and hypromellose through a 80-100 mesh sieve, aztreonam, pea flour, rice bran, brewer's yeast, and compound probiotics The agent is crushed separately and passed through a 200-230 mesh sieve;

[0034] (2) Mix 13.2g of aztreonam, 18g of pea powder, 15g of rice bran, 9g of brewer’s yeast and 6g of compound probiotics, add it to 153g of pure water, stir well and disperse evenly, and pass through a fluidization at a temperature of 50-55°C The bed is dried and crushed at 80-100 mesh to obtain mixture A;

[0035] (3) Mix 67.8g of flucytosine, 30g of maltodextrin and 6g of lactulose and add it to 363g of pure water, fully stir and disperse evenly, then add 1 / 3 of sodium carboxymethyl starch 5g, stir and disperse evenly, Obtain suspension B;

[0036] (4) Spray the mixture A into the suspension B under stirrin...

Embodiment 3

[0039] A kind of flucytosine tablet, its preparation method comprises the following steps:

[0040] (1) Pass flucytosine, maltodextrin, sodium carboxymethyl starch, lactulose, and hypromellose through a 80-100 mesh sieve, aztreonam, pea flour, rice bran, brewer's yeast, and compound probiotics The agent is crushed separately and passed through a 200-230 mesh sieve;

[0041] (2) Mix 7.2g of aztreonam, 15g of pea flour, 12g of rice bran, 7g of brewer’s yeast and 4g of compound probiotics, add them to 82g of pure water, stir well and disperse evenly, and pass through a fluidization at a temperature of 50-55°C The bed is dried and crushed at 80-100 mesh to obtain mixture A;

[0042] (3) After mixing 41.3g of flucytosine, 24g of maltodextrin and 3g of lactulose, add it to 140g of pure water, stir well and disperse evenly, then add 4g of sodium carboxymethyl starch, stir and disperse evenly, Obtain suspension B;

[0043] (4) Spray the mixture A into the suspension B under stirrin...

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Abstract

The invention discloses a flucytosine tablet and a preparation method thereof, and the flucytosine tablet comprises the following components: 31.2-67.8 parts of flucytosine, 4.7-13.2 parts of aztreonam, 20-30 parts of maltodextrin, 14-18 parts of pea meal, 10-15 parts of rice bran, 6-9 parts of beer yeast, 3-6 parts of lactulose, 3-6 parts of a compound probiotic agent, 9-16 parts of sodium carboxymethyl starch, and 3-7 parts of hydroxypropyl methyl cellulose, wherein in each flucytosine tablet, the content of flucytosine is 31.0%-36.0%, and the content of aztreonam is 4.5%-7.0%. The flucytosine tablet can improve the drug resistance of fungi due to long-term administration of flucytosine, reduce the administration frequency and reduce the administration dosage, the preparation method is simple and reliable, the prepared tablet has a smooth surface, the drug quality and the drug effect stability are effectively ensured, and the drug can be quickly dispersed, dissolved out and absorbed in gastrointestinal tracts.

Description

technical field [0001] The invention relates to a flucytosine tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Flucytosine is used for the treatment of fungal infections caused by cryptococcus and candida, such as fungal sepsis, endocarditis, meningitis, and lung and urinary tract infections. Antifungal drugs are mainly used for skin and mucous membrane candidiasis, Candida endocarditis, candida arthritis, cryptococcal meningitis, and chromomycosis; however, blood phase should be checked regularly during the medication period, and patients with hepatic and renal insufficiency and blood diseases and pregnant women should use it with caution, and patients with severe renal insufficiency are contraindicated. Existing flucytosine products are generally capsules, injections, and tablets. Because fungi are prone to develop resistance to flucytosine, fungal drug resistance can be found in a long course of treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K31/513A61K31/427A61K36/899A61K36/064A61K36/48A61K35/745A61K35/747A61K35/744A61P3/02A61P1/00A61P31/10
CPCA61K9/2054A61K9/2095A61K9/2059A61K31/513A61K31/427A61K36/899A61K36/064A61K36/48A61K35/745A61K35/747A61K35/744A61P3/02A61P1/00A61P31/10A61K2300/00
Inventor 郝静梅
Owner 药大制药有限公司
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