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Anti-aging repair nanoemulsion and application thereof

A nano-emulsion and nano-technology, applied in cosmetic preparations, medical preparations containing active ingredients, cosmetics, etc., to achieve remarkable efficacy, good anti-aging repair function, and good anti-aging function

Active Publication Date: 2021-07-13
山东福瑞达生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many anti-wrinkle and anti-aging skin care products / cosmetics at present, there are few reports of using natural raw materials as the main active ingredients to make nano-emulsions for anti-wrinkle and anti-aging. cell availability

Method used

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  • Anti-aging repair nanoemulsion and application thereof
  • Anti-aging repair nanoemulsion and application thereof
  • Anti-aging repair nanoemulsion and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0047] Preparation of Astragalus extract:

[0048] 1) Take the dried Astragalus, soak it, wash the silt and salt on the surface, then dry it in the air, pulverize it, pass it through a 200-mesh sieve, and use cobalt 60 to sterilize it with radiation intensity of 7500- 8500kGy;

[0049] 2) Soak the powder in 2% NaOH solution, at 60°C, ultrasonically extract for 1 h, take a water bath for 4 h, and filter with suction to obtain the supernatant, concentrate, and use chloroform and n-butanol solution (the volume ratio of chloroform: n-butanol 4:1 mixed solution) shake vigorously for 15-20min, stand still for 30min, remove the protein layer and organic solvent layer, repeat several times until there is no protein. Then the chloroform was removed by rotary evaporation, dialyzed for 3-4 days with a dialysis bag, and then freeze-dried to obtain the algae polysaccharides in Starwood sp.

[0050] The seaweed polysaccharide content in the above extract is 60-70% (w / W), the rhamnose cont...

Embodiment 1

[0052] Proportion (weight ratio): SETHIMULSE NANOSOFT nanoemulsifier 5%, dioctyl carbonate 4%, polydimethylsiloxane 1%, Ganoderma lucidum two-way fermentation broth of Chinese herbal medicine, 1% star point algae extract, glycerin 2%, butylene glycol 4%, polyacrylate crosslinked polymer-6 0.3%, PE 9010 0.4%, purified water 77.3%.

[0053] Preparation method of emulsion:

[0054] S1: Oil phase preparation: Add SETHIMULSE NANOSOFT nanoemulsifier into the oil phase (dioctyl carbonate and polydimethylsiloxane), stir slowly (280r / min) until a uniform liquid is formed, and heat to 60-75°C Stir at constant temperature for 10 minutes;

[0055] S2: Water phase preparation: heat purified water, polyacrylate cross-linked polymer-6, glycerin, and butanediol to 60-65°C to form a uniform liquid II;

[0056] S3: Take 1 / 3 of liquid two, slowly add it to liquid one under constant temperature and slow stirring at 60-65°C (280r / min), stir and cool down after complete addition;

[0057] S4: Ad...

Embodiment 2

[0060] Proportion (by weight): SETHIMULSE NANOSOFT nanoemulsifier 8%, dioctyl carbonate 4%, caprylic acid / capric triglyceride 3%, polydimethylsiloxane 1%, Ganoderma lucidum bidirectional fermentation liquid of Chinese herbal medicine 15%, 1.5% of Star Point algae extract, 4% of glycerin, 3% of dipropylene glycol, 0.5% of sodium polyacrylate, 0.8% of caprylyl hydroxamic acid, and 59.2% of purified water.

[0061] Preparation method of emulsion:

[0062] S1: Preparation of oil phase: Add SETHIMULSE NANOSOFT nanoemulsifier into the oil phase, stir slowly (300r / min) until a uniform liquid is formed, heat to 60-75°C and stir for 10 minutes; the oil phase is dioctyl carbonate , caprylic / capric triglyceride and dimethicone;

[0063] S2: Preparation of water phase: heat purified water, sodium polyacrylate, glycerin, and dipropylene glycol to 60-65°C to form a uniform liquid II;

[0064] S3: Take 1 / 3 of liquid 2, slowly add it to liquid 1 under constant temperature and slow stirring ...

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Abstract

The invention discloses an anti-aging repair nanoemulsion and application thereof. The anti-aging repairing nano-particle-size emulsion is prepared by taking the ganoderma lucidum Chinese herbal medicine two-way fermentation liquor and the fortune silverweed extract as main effective components and adding the nano emulsifier, the grease, the polyhydric alcohol, the thickening agent and the preservative, so that the skin cell utilization degree of active substances is promoted, and a better skin care effect is achieved. Experiments prove that the nanoemulsion has a relatively strong anti-aging and repairing function on skin, can promote synthesis of human I-type collagen and inhibit generation of free radicals, has a relatively good anti-photoaging function, and can promote expression of skin barrier related genes, so that the nanoemulsion has a good application prospect in anti-aging and repairing of the skin.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to an anti-aging and repairing nanoemulsion and its application. Background technique [0002] Aging is any physiological change in the body that occurs over time, and the extent and rate of aging varies from individual to individual and is influenced by a variety of causes. Skin aging makes the skin's ability to protect the body and adjust its ability to decline. As a result, the skin cannot adapt to changes in the internal and external environment, and changes in the overall appearance of color, luster, shape, texture, etc., fine wrinkles, decreased elasticity, and sagging skin will appear. , rough, yellowish or sallow skin discoloration, telangiectasia, pigmented spots, etc. The formation process of wrinkles includes endogenous factors (endogenous inflammation, decreased cell viability, free radicals, mental stress, etc.) and exogenous factors (sun exposure, urban pollution, v...

Claims

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Application Information

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IPC IPC(8): A61K8/9794A61K8/9717A61K8/9728A61K8/06A61Q19/08A61Q19/00
CPCA61K8/9728A61K8/9717A61K8/9794A61K8/068A61Q19/08A61Q19/004A61K2800/85A61K2800/82A61K2800/84A61K2800/81A61K2800/21
Inventor 王晓娜韩婷婷杨素珍陈玉荣郭芳钰王兴凯陈博文
Owner 山东福瑞达生物股份有限公司
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