The invention discloses a damp-proof and anti-collision computer host protection device. The device comprises a shell, a main protection plate, a top plate, an auxiliary protection plate, a main limiting plate, an auxiliary limiting plate, a limiting spring, a telescopic spring, an auxiliary protection groove, a drawer, a connecting rod, a pull ring, a sliding rod, a fixed rod, a movable block, apull rod, an arc-shaped plate, a protection spring, a rotating rod, a connecting block, a connecting spring and a convex block; main protection grooves are symmetrically formed in the two corresponding sides of the shell. The auxiliary protection groove is formed in one end of the shell. The limiting spring and the telescopic spring are extruded through the main protection plate and the auxiliaryprotection plate; the limiting spring and the telescopic spring generate reverse elastic force after being compressed; the main protection plate or the auxiliary protection plate is pushed to move inthe direction away from a containing groove, so that the host is fixed, air in the host is dehumidified through the drying agent, the damp-proof function is achieved, the host is protected, the time consumed for repairing the host is saved, and the working efficiency is improved.