Preparation and application of amino acid-based polyurethane supramolecular high-viscosity gel patch
An amino acid-based, polyurethane technology, used in applications, surgical adhesives, medical science and other directions, can solve the problems of application limitations, unsatisfactory mechanical properties, poor material molding processability, etc., to achieve flexible mechanical properties, degradation products are safe and non-toxic, Healing effect
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example 1
[0051] The amino acid-based polyurethane supramolecular composite tissue adhesive prepared by the present invention is prepared from the following components by weight: 100 parts of polyethylene glycol, 60 parts of DMPA, 5 parts of cyclodextrin, 150 parts of isocyanate, triethylamine 8 parts, modified gelatin 30 parts, amino acid 25 parts, catalyst 0.5 parts, acetone 100 parts, medical distilled water 300 parts.
[0052] The preparation method of the designed tissue adhesive is as follows: (1) Weigh the polyester polyol containing hydroxyl (including but not limited to polyethylene glycol) and place it in a mortar, repeatedly grind it into powder, and pour it into a beaker After vacuum drying at 80 degrees to remove water; (2) adding the treated polyester polyol into a round bottom flask. Control the temperature to 80 degrees, redissolve it, and stir it to make it stir at a uniform speed. After 30 minutes, add a certain amount of cyclodextrin to make it mix evenly and fully; ...
example 2
[0054] The amino acid-based polyurethane tissue adhesive prepared by the present invention is prepared from the following components in parts by weight: 100 parts of polyethylene glycol, 80 parts of DMPA, 3 parts of cyclodextrin, 180 parts of isocyanate, 10 parts of triethylamine, 35 parts of modified gelatin, 20 parts of amino acid, 0.8 part of catalyst, 120 parts of acetone, 350 parts of medical distilled water.
[0055] The preparation method of the tissue adhesive of the present invention is as follows: (1) Weigh polyester polyols containing 2-3 hydroxyl groups (including but not limited to polycaprolactone) and grind them into powder, pour them into a beaker and undergo high-temperature reduction. Press and dry to remove water for 12 hours; (2) Add the treated polyester polyol into a round bottom flask, raise the temperature and keep the temperature at 80 degrees, dissolve it, add a predetermined amount of cyclodextrin three times after dissolving and stir it at a constant...
example 3
[0057] The amino acid-based polyurethane tissue adhesive prepared by the present invention is prepared from the following components in parts by weight: 100 parts of polyethylene glycol, 40 parts of DMPA, 15 parts of cyclodextrin, 130 parts of isocyanate, 5 parts of triethylamine, 35 parts of modified gelatin, 35 parts of amino acid, 0.5 part of catalyst, 120 parts of acetone, 280 parts of medical distilled water.
[0058] The preparation method of the tissue adhesive of the present invention is: (1) Weigh the polyester polyol containing bifunctional group (including but not limited to polylactic acid) and grind it into powder, pour it into a beaker, heat it and dry it under reduced pressure to remove water 24h; (2) Add the treated polyester polyol into the round bottom flask and heat it to 80 degrees until it is completely dissolved, then add a predetermined amount of cyclodextrin in three times and stir it at a constant speed to make it mix evenly and fully (3) Add the isocy...
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