Preparation method of injectable adaptive natural hydrogel adhesive

Abstract

The preparation method of injectable self-adaptive natural hydrogel adhesive, first synthesizes gelatin-phenylboronic acid with carboxyphenylboronic acid and gelatin through amidation reaction, or synthesizes polysaccharide-phenylboronic acid with aminophenylboronic acid and natural polysaccharide; And through amidation React dopamine and gelatin or natural polysaccharides to synthesize gelatin-dopamine or polysaccharide-dopamine; then dissolve gelatin-phenylboronic acid / polysaccharide-phenylboronic acid in phosphate buffer solution, gelatin-dopamine / polysaccharide-dopamine in polyphenol-containing substances In the phosphate buffer solution, the two are mixed well, and the spontaneous esterification reaction between phenylboronic acid and polyphenols can occur, forming a reversible borate bond, and finally an injectable self-adaptive natural hydrogel adhesive is prepared. ; The hydrogel adhesive of the present invention has good bioadhesion and antibacterial and anti-inflammatory effects, and can be attached to the tissue surface and play a repairing role; it has good mechanical self-adaptive properties and can match different dynamic tissues deformation and frequency.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a preparation method of an injectable self-adaptive natural hydrogel adhesive for repairing lung damage. Background technique [0002] Pneumothorax (pneumothorax) refers to the gas into the pleural cavity, resulting in a state of pneumothorax, known as pneumothorax. The lung tissue and visceral pleura are usually ruptured due to lung disease or external force, or the tiny emphysema bubbles near the lung surface are ruptured, and the air in the lungs and bronchi escapes into the pleural cavity. Generally speaking, those caused by chest wall or lung trauma are called traumatic pneumothorax; those caused by spontaneous rupture of lung tissue due to disease are called "spontaneous pneumothorax". The incidence of traumatic pneumothorax accounts for 15% to 50% in blunt trauma and 30% to 87.6% in penetrating trauma. Mostly because the lung is punctured by the broken end of t...

AI Technical Summary

Problems solved by technology

There is no clinically effective method for repairing damaged lung tissue. The main reasons are as follows: (1) The lung tissue cannot be sutured with surgical needles and threads, because it will cause new air leakage points; (2) The lung tissue is soft and dynamic. The contraction-expansion entity, the mechanical hardness of the existing medical adhesive is too large, and the adhesion on the surface of the lung tissue cannot adapt to the dynamic change of the lung surface deformation, resulting in uncoordinated local deformation and excessive strain, which may cause Additional lung function damage; (3) The cost of thoracotomy is high, the patient is damaged greatly, and the operation is difficult. Even with minimally invasive surgery, the wound is still much larger than that of acupuncture or catheter