Preparation method of controllably degradable bone implantation composite material

A composite material and bone implantation technology, applied in the field of preparation of bone implant composite materials, can solve the problems of increased loosening rate of metal bone implants, poor integration of implants and bone, and loosening of implants. Does not cause local inflammation, no hemolytic activity, and does not affect the effect of osteogenesis

Inactive Publication Date: 2021-08-20
杭州鹿扬科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The vast majority of bone implant materials are metal, and the elastic modulus of metal and bone is very different. The interface between the material and bone will form a stress barrier, which makes the implant and bone not well integrated, and even causes osteolysis around the material. lead to implant loosening and failure
Epidemiological studies have confirmed that compared with the normal population, the loosening rate of metal bone implants in diabetic patients is significantly higher, among which the loosening rate of spinal screws is as high as 30%. Loosening causes implant failure and may damage the surrounding area. The bones, muscles, nerves and blood vessels and other tissues in the body have caused great pain and even life-threatening to patients, but this serious clinical problem has not been effectively solved at present

Method used

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  • Preparation method of controllably degradable bone implantation composite material
  • Preparation method of controllably degradable bone implantation composite material
  • Preparation method of controllably degradable bone implantation composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] [Example 1]: A controllable degradable bone implant composite material:

[0074] This embodiment provides a controllable degradable bone implant composite material, which includes:

[0075] 38.0wt% nano-bioglass material and 61.0wt% amino acid polymer as the main structure;

[0076] 1.0 wt% modified calcium carbonate whiskers / natural rubber latex compound as a synergistic ingredient;

[0077] Wherein, graphene is added in the modified calcium carbonate whisker / natural rubber latex compound as synergistic composition;

[0078] The graphene contains 20wt% reduced graphene.

[0079] The bone implant composite material described in this example was prepared through the following steps:

[0080] 1. ε-aminocaproic acid, arginine nonamer and other α-amino acids are miscible in deionized water, dehydrated under nitrogen protection, heated to 215°C for 2 hours, and then heated to 235°C for 2 hours;

[0081] 2. Add nano-biological glass material and synergistic component modi...

Embodiment 2

[0092] [Example 2]: Another kind of bone implant composite material:

[0093] This embodiment provides another bone implant composite material, its formula and preparation method are basically the same as in Example 1, the only difference is that no modified calcium carbonate whiskers are added to the bone implant composite material in this embodiment / Natural latex compound as a synergistic component, that is, the bone implant composite material contains 38.0wt% nano-biological glass material and 62.0wt% amino acid polymer; except that this point is different, all the other formulas and preparation steps are the same as those in Example 1 and made bone implant composites.

Embodiment 3

[0094] [Example 3]: Another kind of bone implant composite material:

[0095] This embodiment provides another bone implant composite material, its formula and preparation method are basically the same as in Example 1, the only difference is that in this embodiment, when preparing calcium carbonate whiskers / natural rubber latex composite, calcium carbonate Whiskers were completely dispersed in deionized water without modification by stearic acid to obtain a whisker dispersion; except for this point, the rest of the formula and preparation steps were the same as in Example 1 to obtain a bone implant composite material.

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a controllably degradable bone implantation composite material and a preparation method thereof. The bone implantation composite material comprises a nano bioglass material as a main structure, an amino acid polymer, and a modified calcium carbonate whisker / natural latex compound as a synergistic component, wherein graphene is added into the modified calcium carbonate whisker / natural latex compound serving as the synergistic component. According to the preparation method, the raw materials of the bone implantation composite material have good biological activity and biocompatibility, interaction between tissues and cells and the material is facilitated, the composite material has enough mechanical strength, meanwhile, the composite material can be rapidly degraded in the later period, the degradation rate of the bone implantation composite material can be adjusted by changing components, and the controllable degradation of the bone implantation composite material is realized.

Description

[0001] Original application number: 2020102527221, name: Controlled degradation of bone implant composite material and its preparation method, application date: April 02, 2020. technical field [0002] The invention relates to the technical field of biomedical materials, in particular to a preparation method of a controllable degradable bone implant composite material. Background technique [0003] Orthopedic disease is one of the diseases with high morbidity, which seriously affects the quality of life of patients. Bone defects are common in orthopedic diseases. Traditional bone defect treatment methods include autologous bone graft, allogeneic bone graft, and artificial bone graft. Autologous bone is an ideal material for bone defect repair, but the bone harvesting process increases the trauma and pain of patients, and the source of bone supply is limited, making it difficult to shape; allogeneic bone has immune rejection, and can spread diseases or cause postoperative co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/18A61L27/02A61L27/08A61L27/16A61L27/50A61L27/58
CPCA61L27/025A61L27/08A61L27/10A61L27/165A61L27/18A61L27/50A61L27/58A61L2300/412A61L2400/12A61L2430/02C08L77/04C08L9/04
Inventor 不公告发明人
Owner 杭州鹿扬科技有限公司
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