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Amphiphilic graphene quantum dot modified by water-soluble pillararene, preparation method and application thereof

A technology of graphene quantum dots and water-soluble pillar aromatic hydrocarbons, which is applied in the preparation of organic compounds, ether preparation, and ester reaction preparation of ethers, etc. Insufficient affinity and other problems, to avoid the introduction of impurities, improve affinity, and simple methods

Active Publication Date: 2021-08-20
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, most of the synthesized graphene quantum dots are hydrophilic or lipophilic, and can only be used in a single solvent, which greatly limits the conditions of use of graphene quantum dots for cell imaging.
Traditional hydrophilic carbon dots or graphene quantum dots, due to the existence of a hydrophobic interface, do not have a good affinity with the cell membrane during imaging and cannot obtain clear images

Method used

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  • Amphiphilic graphene quantum dot modified by water-soluble pillararene, preparation method and application thereof
  • Amphiphilic graphene quantum dot modified by water-soluble pillararene, preparation method and application thereof
  • Amphiphilic graphene quantum dot modified by water-soluble pillararene, preparation method and application thereof

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[0031] A method for preparing amphiphilic graphene quantum dots modified by water-soluble pillar aromatics, comprising the following steps: (1) preparing amphiphilic graphene quantum dots; (2) preparing water-soluble pillar aromatic hydrocarbons; Amphiphilic graphene quantum dots are mixed with water-soluble pillar arenes in aqueous solution, the alkyl chains on the amphiphilic graphene quantum dots are combined with the cavity of the pillar arenes through hydrophobic interaction, and the ammonium salts with cations on the pillar arenes are combined with The hydroxyl groups on the amphiphilic graphene quantum dots are combined by electrostatic interaction to obtain water-soluble pillar arene-modified amphiphilic graphene quantum dots.

[0032] The mixing in the step (3) is: the mass ratio of the amphiphilic graphene quantum dots to the water-soluble pillar arene is 1:1-4. Only within the above mass ratio range can the water-soluble pillararene be well combined with the amphiph...

Embodiment 1

[0037] The embodiment of the present invention provides a method for preparing water-soluble pillararene-modified amphiphilic graphene quantum dots, the specific steps are as follows:

[0038] Step 1: Mix 3.3.3g, 30mmol of hydroquinone and 11.056g, 80mmol of anhydrous potassium carbonate in a 250mL three-round-bottomed flask, and stir at 60°C for 2h under a nitrogen atmosphere. Then, 40 mL excess of 1,2-dibromoethane was added. The reaction mixture was stirred at 60 °C under nitrogen atmosphere for 24 h and filtered. The filtrate was evaporated on a rotary evaporator to remove 1,2-dibromoethane and solvent. The residue was dissolved in 100 mL of chloroform, washed three times with 50 mL of sodium hydroxide solution and twice with 50 mL of water. The extract was dried over anhydrous magnesium sulfate. Remove CHCl 3 , dried under vacuum at 40°C to obtain 1,4-bis(2-bromoethoxy)benzene with a purity of 35% as a light brown powder, and its synthesis diagram is shown in Figure ...

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Abstract

The invention discloses a water-soluble pillararene modified amphiphilic graphene quantum dot, a preparation method and application. The water-soluble pillararene modified amphipathic graphene quantum dot is prepared by modifying an amphipathic graphene quantum dot with water-soluble pillararene so as to obtain the water-soluble pillararene modified amphipathic graphene quantum dot, wherein the amphiphilic graphene quantum dot and the water-soluble pillararene are combined through hydrophobic interaction and electrostatic interaction to form the amphiphilic graphene quantum dot modified by the water-soluble pillararene. According to the invention, the preparation method is easy to operate and good in repeatability; and the prepared modified amphiphilic graphene quantum dot emits strong green fluorescence, wherein after water-soluble pillararene modification, the fluorescence intensity is enhanced, the affinity is high, the quantum dot can penetrate through a cell membrane more easily, and the quantum dot has low toxicity and biocompatibility and can be used for cell imaging.

Description

technical field [0001] The application relates to a water-soluble pillar arene-modified amphiphilic graphene quantum dot, a preparation method and an application. Background technique [0002] Due to the quantum confinement effect and boundary effect, graphene quantum dots have been paid attention to in fluorescent materials. Graphene quantum dots (GQDs) can be regarded as small graphite fragments, usually single-layer, double-layer or multi-layer (3-10) zero-dimensional graphite nanomaterials with lateral dimensions less than 100 nm, which have unique fluorescent properties. At present, most of the synthesized graphene quantum dots are hydrophilic or lipophilic, and can only be used in a single solvent, which greatly limits the use conditions of graphene quantum dots for cell imaging. Traditional hydrophilic carbon dots or graphene quantum dots, due to the existence of a hydrophobic interface, do not have a good affinity with the cell membrane during imaging and cannot obt...

Claims

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Application Information

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IPC IPC(8): C09K11/65C09K11/02B82Y20/00B82Y40/00C01B32/15C07C213/02C07C217/20G01N21/64
CPCC09K11/65C09K11/025B82Y20/00B82Y40/00C01B32/15C07C213/02C07C41/30C07C41/16G01N21/6486C07C217/20C07C43/225
Inventor 郑莹莹邹昊柳兵
Owner ZHEJIANG SCI-TECH UNIV
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