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Preparation method of multi-composite-process layered intravascular stent

A technology of vascular stent and composite process, which is applied in the field of vascular stent forming system based on electrospinning and micro-imprinting technology, can solve the problems of difficult stent layered structure, achieve high stent strength, ensure mechanical strength, and be easy to control Effect

Inactive Publication Date: 2021-08-24
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these traditional methods have obtained relatively successful vascular stents or stents with a vascular network, it is difficult to achieve a hierarchical structure of the stent in the current process for preparing vascular stents.

Method used

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  • Preparation method of multi-composite-process layered intravascular stent
  • Preparation method of multi-composite-process layered intravascular stent
  • Preparation method of multi-composite-process layered intravascular stent

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preparation example Construction

[0044] And disclose a kind of preparation method of multi-composite process layered vascular stent, comprising the following steps:

[0045] (1) Forming the basic film of the inner layer of the blood vessel: the solid particles of the raw material are melted into a liquid state and then transferred to the embossing machine platform. Using micro-imprinting technology, the liquid material is embossed into a film by adjusting the air pressure, temperature and time, and then at room temperature Cool to obtain the base film;

[0046] (2) Form the tubular structure of the vascular stent: use the pre-prepared through-hole cylinder, insert the tweezers from one end of the through-hole cylinder, and extend the other end, clamp the base film and drag it into the through-hole cylinder, The base film is curled into a tubular scaffold under the action of the inner wall of the through-hole cylinder;

[0047] (3) Forming the outer layer of the vascular stent: Driven by the three-axis motion...

Embodiment 1

[0050] see figure 1 , a layered vascular stent forming system based on electrospinning and micro-imprinting technology, including a feeding system 1, a spinning collection system 2, a three-axis motion platform 3, and a power supply 4. The feeding system 1 is directly connected to the syringe of the needle Connected; the spinning collection system 2 is fixedly installed on the XY axis platform of the three-axis motion platform 3, the positive pole of the power supply 4 is connected to the metal part of the syringe needle 5, and the negative pole is connected to the metal part of the spinning collector 6.

Embodiment 2

[0052] This embodiment is basically the same as Embodiment 1, the difference is only in:

[0053] The feeding system 1 includes a micropump syringe 7 and a connecting conduit 8, and the micropump actuator is driven by the micropump controller to push the syringe piston cylinder to extrude the spinning material;

[0054] The spinning collection system 2 is fixedly connected to the XY axis plane of the three-axis motion platform 3, the positive pole of the power supply 4 is connected to the metal part of the syringe needle 5, and the negative pole is connected to the metal part of the spinning collector 6, so that the syringe needle 5 and the spinning collection system 2 to form a high-voltage electric field.

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Abstract

The invention discloses a layered intravascular stent forming method based on combination of electrostatic spinning and a micro-imprint technology. The method comprises the following steps: firstly, preparing a basic film as an inner layer of a blood vessel through the micro-imprint technology; the preparation method comprises the following steps: preparing a thin film, clamping the thin film into a tubular shape through a pre-designed mold, assembling the thin film on a rotating motor, finally forming the outermost layer of the intravascular stent through an electrostatic spinning process under the driving of a three-axis motion platform, and finally forming a double-layer intravascular stent with enough mechanical strength, the inner layer provides a growth environment, and the outer layer mainly provides mechanical properties. The device has the advantages of being high in automation degree, easy to control, high in stent strength and the like, and is suitable for forming intravascular stents with layered structures and various materials in tissue engineering.

Description

technical field [0001] The invention relates to the technical fields of mechanical manufacturing and biomanufacturing, and more specifically relates to a vascular stent forming system and method based on electrospinning and micro-imprinting technologies, which can realize the preparation of double-layer vascular stents. Background technique [0002] In today's society, people pay more and more attention to the problem of cardiovascular diseases. In the clinic, due to the lack of reliable alternatives such as autologous vascular stents, the treatment of angiogenesis is affected. Therefore, there is an urgent clinical need for a large number of vascular substitutes, and the construction of functional tissue vascular scaffolds has broad application prospects. [0003] The inner diameter of blood vessels in the human body ranges from 5 microns to 25 mm. The blood vessels involved in hemostasis are mainly arterioles, venules, capillaries and microcirculatory blood vessels. Althou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61F2/07
CPCA61F2/06A61F2/07A61F2240/001
Inventor 刘媛媛胡俊超王斌简志安陆春翔张毅高闯郭子龙刘娜兰伟霞岳涛
Owner SHANGHAI UNIV
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