Composite material for selectively separating and enriching podophyllotoxin and preparation method thereof

Abstract

The invention relates to a composite material for selectively separating and enriching podophyllotoxin and a preparation method thereof. The preparation method comprises the following steps: adding podophyllotoxin as a template molecule, graphene oxide, modified hydroxy propyl cellulose, a functional monomer, a cross-linking agent and an initiator into a polymerization solvent; then reacting in an inert atmosphere to synthesize a molecularly imprinted polymer, and washing off the template molecule podophyllotoxin to obtain the composite material, wherein the modified hydroxy propyl cellulose is prepared by the following steps: under the catalytic action of triethylamine, modifying hydroxy propyl cellulose by using acryloyl chloride, so as to obtain methacryloyl-hydroxy propyl cellulose containing a carbon-carbon double bond. The composite material prepared by the invention has the advantages of stable selectivity, relatively high extraction efficiency, rapid detection and the like, and can realize selective separation and enrichment of podophyllotoxin in complex samples such as a water sample and the like.

Description

technical field [0001] The invention relates to the fields of preparation of molecularly imprinted polymer materials and solid phase extraction, in particular to a composite material for selective separation and enrichment of podophyllotoxin and a preparation method thereof. Background technique [0002] Podophyllum is a perennial herb belonging to the subfamily Podophyllidae of the Berberidaceae family. Modern pharmacological studies have shown that the main component, podophyllotoxin, has significant effects in anti-cancer and anti-virus, and has received more and more attention. As a natural medicinal material, dozens of lignan compounds can be obtained from the podophyllum fruit alone. In addition, there are also a variety of flavonoids, mainly including quercetin, kaempferol and their glycosides. Make the separation and extraction of podophyllotoxin more difficult. At the same time, podophyllotoxin, as a drug, will enter the environment through the human body or in ot...

AI Technical Summary

Problems solved by technology

However, there are two main problems in traditional molecularly imprinted polymer materials: I. There is agglomeration phenomenon in the material, which embeds the specific recognition site; II. The specific adsorption capacity of the material is low.

At present, various pretreatment technologies generally have a polarized development trend, that is, their applicability drops sharply when pursuing high selectivity, and when pursuing method applicability to achieve high-throughput analysis, the selectivity of sample pretreatment methods is poor

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