Manganese dioxide/iron platinum composite nanomaterial with synergistic catalysis function and preparation method and application thereof

A composite nanomaterial and manganese dioxide technology, applied in the field of manganese dioxide/iron platinum composite nanomaterials and their preparation, can solve the problems of insufficient OH amount, limitation of chemokinetic therapy, consumption of oxygen, etc.

Active Publication Date: 2021-09-17
LINYI UNIVERSITY
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  • Abstract
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Problems solved by technology

[0004] However, the above catalytic reactions have their own limitations in practical applications
Due to the H in cells 2 o 2 The content is limited, resulting in insufficient amount of OH catalyzed in the Fenton reaction, which limits the chemokinetic therapy in tumor treatment.
On the other hand, GOx catalyzes the glucose decomposition reaction and needs to consume oxygen, which is obviously contradictory to the acidic and hypoxic environment of tumor tissue itself, which greatly limits the application of this catalytic therapy in tumor treatment.

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  • Manganese dioxide/iron platinum composite nanomaterial with synergistic catalysis function and preparation method and application thereof
  • Manganese dioxide/iron platinum composite nanomaterial with synergistic catalysis function and preparation method and application thereof
  • Manganese dioxide/iron platinum composite nanomaterial with synergistic catalysis function and preparation method and application thereof

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preparation example Construction

[0029] The invention provides a method for preparing a manganese dioxide / iron-platinum composite nanomaterial with synergistic catalytic function, comprising the following steps:

[0030] (1) Ultrasonic mixing of FePt nanoparticles, unsaturated fatty acid and polar organic solvent to remove the polar organic solvent to obtain a pre-dispersion;

[0031] (2) The predispersion liquid is mixed with potassium permanganate solution, and a reduction reaction is carried out to obtain MnO 2 @FePt nanomaterials;

[0032] (3) the MnO 2 The @FePt nanomaterial was stirred and mixed with glucose oxidase, bovine serum albumin, and water to obtain a manganese dioxide / iron platinum composite nanomaterial with synergistic catalytic function.

[0033] In the invention, FePt nanoparticles, unsaturated fatty acid and polar organic solvent are ultrasonically mixed, and then the polar organic solvent is removed to obtain a predispersion liquid. In the present invention, the particle diameter of t...

Embodiment 1

[0056] (1) Preparation of FePt nanoparticles

[0057] Add 0.39g of platinum acetylacetonate and 0.35g of iron acetylacetonate into 43mL of dioctyl ether and 0.78g of 1,2-hexadecanediol mixed solution, under the protection of argon, heat to 110°C for 15 minutes, add 0.22mL Oleylamine and 0.21mL oleic acid were heated to 295°C for 1 hour. After the reaction was completed, it was centrifuged and washed with ethanol to obtain FePt nanoparticles with a particle size of 3 nm.

[0058] (2)MnO 2 Preparation of @FePt:

[0059] 5 mg of FePt nanoparticles with a particle size of 3 nm were dispersed in 12 mL of chloroform, and 1.5 mL of oleic acid was added thereto after ultrasonication for 5 min. Sonication was continued for 25 min, and then the mixture was rotary evaporated to remove chloroform. Finally, the solid-liquid mixture after rotary evaporation was added to 30 mL of 20 mM potassium permanganate solution, and stirred at 25° C. overnight. After the reaction was completed, ce...

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Abstract

The invention provides a manganese dioxide / iron platinum composite nanomaterial with a synergistic catalysis function and a preparation method and application thereof, and belongs to the technical field of antitumor drugs. FePt nanoparticles, unsaturated fatty acid and a polar organic solvent are ultrasonically mixed to obtain a mixed solution of the FePt nanoparticles and the unsaturated fatty acid. The preparation method comprises the following steps that a pre-dispersion liquid is mixed with a potassium permanganate solution, a reduction reaction is carried out, potassium permanganate is reduced into manganese dioxide by using unsaturated fatty acid in the pre-dispersion liquid, the unsaturated fatty acid is attached to the surfaces of the FePt nanoparticles, carboxyl of the unsaturated fatty acid can be combined with manganese dioxide, manganese dioxide grows on the surfaces of the FePt nanoparticles, and MnO2@FePt nanoparticles are obtained. The MnO2@FePt nanomaterials are stirred and mixed with glucose oxidase, bovine serum albumin and water, and the glucose oxidase and the bovine serum albumin can be loaded on the surface of manganese dioxide.

Description

technical field [0001] The invention relates to the technical field of antitumor drugs, in particular to a manganese dioxide / iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application. Background technique [0002] Tumor has become one of the major diseases threatening human health, and its morbidity and mortality are still rising. At present, the conventional treatment methods for tumors include surgical resection, chemotherapy and radiotherapy, etc. However, these treatments often have disadvantages such as large side effects, high recurrence rate, and low treatment efficiency. [0003] In recent years, many new tumor treatment methods have been developed based on catalytic reactions in vivo, such as chemokinetic therapy and starvation therapy. Among them, chemokinetic therapy is to use the Fenton reaction or Fenton-like reaction of inorganic metal nanomaterials to convert hydrogen peroxide (H 2 o 2 ) catalyzes th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K47/54A61K47/69A61P35/00B82Y5/00B82Y30/00B82Y40/00A61K33/26A61K33/32A61K38/38
CPCA61K47/6923B82Y30/00B82Y5/00B82Y40/00A61P35/00A61K38/443C12Y101/03004A61K38/385A61K47/542A61K33/32A61K33/26A61K2300/00
Inventor 戴志超寇运凯田露胡尊富孙运强郑秀文
Owner LINYI UNIVERSITY
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