Manganese dioxide/iron platinum composite nanomaterial with synergistic catalysis function and preparation method and application thereof

Abstract

The invention provides a manganese dioxide / iron platinum composite nanomaterial with a synergistic catalysis function and a preparation method and application thereof, and belongs to the technical field of antitumor drugs. FePt nanoparticles, unsaturated fatty acid and a polar organic solvent are ultrasonically mixed to obtain a mixed solution of the FePt nanoparticles and the unsaturated fatty acid. The preparation method comprises the following steps that a pre-dispersion liquid is mixed with a potassium permanganate solution, a reduction reaction is carried out, potassium permanganate is reduced into manganese dioxide by using unsaturated fatty acid in the pre-dispersion liquid, the unsaturated fatty acid is attached to the surfaces of the FePt nanoparticles, carboxyl of the unsaturated fatty acid can be combined with manganese dioxide, manganese dioxide grows on the surfaces of the FePt nanoparticles, and MnO2@FePt nanoparticles are obtained. The MnO2@FePt nanomaterials are stirred and mixed with glucose oxidase, bovine serum albumin and water, and the glucose oxidase and the bovine serum albumin can be loaded on the surface of manganese dioxide.

Description

technical field [0001] The invention relates to the technical field of antitumor drugs, in particular to a manganese dioxide / iron-platinum composite nanomaterial with synergistic catalytic function and its preparation method and application. Background technique [0002] Tumor has become one of the major diseases threatening human health, and its morbidity and mortality are still rising. At present, the conventional treatment methods for tumors include surgical resection, chemotherapy and radiotherapy, etc. However, these treatments often have disadvantages such as large side effects, high recurrence rate, and low treatment efficiency. [0003] In recent years, many new tumor treatment methods have been developed based on catalytic reactions in vivo, such as chemokinetic therapy and starvation therapy. Among them, chemokinetic therapy is to use the Fenton reaction or Fenton-like reaction of inorganic metal nanomaterials to convert hydrogen peroxide (H 2 o 2 ) catalyzes th...

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Problems solved by technology

[0004] However, the above catalytic reactions have their own limitations in practical applications

Due to the H in cells 2 o 2 The content is limited, resulting in insufficient amount of OH catalyzed in the Fenton reaction, which limits the chemokinetic therapy in tumor treatment.

On the other hand, GOx catalyzes the glucose decomposition reaction and needs to consume oxygen, which is obviously contradictory to the acidic and hypoxic environment of tumor tissue itself, which greatly limits the application of this catalytic therapy in tumor treatment.

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