Gene medicine for preventing and treating neovascular eye diseases

A technology for eye diseases and genes, which is applied in the fields of cardiovascular system diseases, gene therapy, sensory diseases, etc., can solve the problems that subjects are prone to infection and inflammation, difficult to apply, etc., to achieve inhibition of proliferation and migration activity, inhibition of proliferation, The effect of inhibiting angiogenesis ability
CN113481237APending Publication Date: 2021-10-08厦门朔望医药科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
厦门朔望医药科技有限公司
Publication Date
2021-10-08

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Abstract

The invention discloses a gene medicine for preventing and treating neovascular eye diseases. The invention relates to the technical field of gene medicines, in particular to a recombinant vector which comprises a PEDF or PEDF functional fragment gene and a shRNA fragment targeting human VEGFA (vascular endothelial growth factor A). The invention also provides application of the recombinant vector in preparation of medicines for preventing or treating angiogenesis-related eye diseases. The PEDF overexpression and VEGFA interference adeno-associated virus involved in the invention can interfere with the expression level of the VEGFA in vascular endothelial cells, effectively down-regulate the protein level of the VEGFA, further inhibit the proliferation and migration activity of the vascular endothelial cells, and inhibit the angiogenesis ability of the vascular endothelial cells, so that a new target and approach for the treatment of wet maculopathy is provided.
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Description

technical field

[0001] The invention relates to the technical field of gene medicine, in particular to a gene medicine for preventing or treating eye diseases related to angiogenesis. Background technique

[0002] Angiogenic diseases are mainly caused by an imbalance between pro-angiogenic and anti-angiogenic factors. Stimulating factors such as biological force, hyperoxia, thrombus, immune and inflammatory responses, and genetic mutations can all cause abnormalities in angiogenesis. Angiogenesis in the eye can occur in the retina, choroid, and cornea, and uninhibited angiogenesis can lead to severe visual impairment. The new blood vessels are secretory, and the accumulation of secretions in the long-term will eventually lead to the damage of retinal function. In addition, abnormal growth of blood vessels can lead to abnormal tissue structure and impaired corneal transparency. Ophthalmic diseases associated with neovascularization include wet maculopathy, diabetic retinop...

Claims

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