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Polyether sulfone hemodialysis membrane with heparin-like modified coating as well as preparation method and application of polyether sulfone hemodialysis membrane

A hemodialysis and modified coating technology, which is applied in the field of hemodialysis membranes and medical materials, can solve the problems of high price and thrombocytopenia, and achieve the effects of various performance improvements, simple structure, and broad market application prospects

Active Publication Date: 2021-10-29
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The search found that Chinese patent CN110917892B discloses a hemodialysis membrane that intervenes in oxidative stress and anticoagulation and its preparation method. -Trihydroxymethylaminomethane buffer solution, anticoagulant-phosphate buffer solution to treat the hemodialysis membrane, although the modified hemodialysis membrane thus prepared can inhibit oxidative stress and prevent thrombosis, but the selected anticoagulant It is a heparin compound, which is not only expensive but also causes thrombocytopenia, which can lead to problems such as spontaneous bleeding (see R.Luo, J. Zhang, W. Zhuang, L. Deng, L. Li, H. Yu, J. Wang , N. Huang, Y. Wang, Multifunctional coatings that mimic the endothelium: Surface bound active heparin nanoparticles with: In situation generation of nitric oxide from nitrogen, J. Mater. Chem. B.6 (2018) 5582–5595)

Method used

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  • Polyether sulfone hemodialysis membrane with heparin-like modified coating as well as preparation method and application of polyether sulfone hemodialysis membrane
  • Polyether sulfone hemodialysis membrane with heparin-like modified coating as well as preparation method and application of polyether sulfone hemodialysis membrane
  • Polyether sulfone hemodialysis membrane with heparin-like modified coating as well as preparation method and application of polyether sulfone hemodialysis membrane

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Embodiment 1

[0026] The modification principle of embodiment 1 of the present invention and concrete reaction are as figure 1 Shown, the following is the specific preparation process:

[0027] (1) Pretreat the polyethersulfone membrane by immersing it in ethanol at 25°C for 0.5h.

[0028] (2) Take out the polyethersulfone membrane pretreated in (1), wash it with deionized water, soak it in pH=8.5 and contain α-aminosuccinic acid monoamide (concentration in the solution is 10wt%), single Ning (concentration in the solution is 2wt%) mixed aqueous solution, immersion modification at 40 ℃ for 12h.

[0029] (3) After taking out the polyethersulfone membrane modified in (2) and washing it with deionized water, soak it again in an aqueous solution of 3-mercapto-1-propanesulfonate with a concentration of 10 wt%, and soak it at 40°C Modification 10h.

[0030] (4) The modified polyethersulfone membrane in (3) is taken out and fully washed with deionized water to obtain a coated modified polyether...

Embodiment 2

[0047] (1) Pretreat the polyethersulfone membrane by immersing it in ethanol at 25°C for 0.5h.

[0048] (2) Take out the polyethersulfone membrane pretreated in (1), wash it with deionized water, soak it in pH=8.5 and contain α-aminosuccinic acid monoamide (concentration in the solution is 1wt%), single Ning (concentration in the solution is 2wt%) mixed aqueous solution, immersion modification at 40 ℃ for 12h.

[0049] (3) After taking out the modified polyethersulfone membrane in (2) and washing it with deionized water, soak it again in an aqueous solution of 3-mercapto-1-propanesulfonate with a concentration of 1 wt%, and soak it at 40°C Modification 12h.

[0050] (4) The modified polyethersulfone membrane in (3) is taken out and fully washed with deionized water to obtain a coated modified polyethersulfone hemodialysis membrane.

Embodiment 3

[0052] (1) Soak the polyethersulfone membrane in isopropanol at 25°C for 0.5h pretreatment.

[0053] (2) The polyethersulfone membrane pretreated in (1) is taken out, washed with deionized water, soaked in pH=7.8 and containing 2-amino-4-formamidobutyric acid (concentration in the solution is 10wt%) ), tannin (concentration in the solution is 2wt%) in the mixed aqueous solution, immersion modification at 25 ℃ for 12h.

[0054] (3) After taking out the polyethersulfone membrane modified in (2) and washing it with deionized water, soak it again in an aqueous solution of 3-mercapto-1-propanesulfonate with a concentration of 10 wt%, and soak it at 25°C Modification 12h.

[0055] (4) The modified polyethersulfone membrane in (3) is taken out and fully washed with deionized water to obtain a coated modified polyethersulfone hemodialysis membrane.

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Abstract

The invention relates to a polyether sulfone hemodialysis membrane with a heparin-like modified coating as well as a preparation method and application of the polyether sulfone hemodialysis membrane. The preparation method comprises the steps of firstly, soaking the polyether sulfone hemodialysis membrane in an alcohol solvent, taking out the polyether sulfone hemodialysis membrane, soaking the polyether sulfone hemodialysis membrane in a modification liquid composed of a carboxyl-containing water-soluble monomer and a polyphenol water-soluble substance, taking out the polyether sulfone hemodialysis membrane, soaking the polyether sulfone hemodialysis membrane in a sulfonic acid group-containing water-soluble monomer modification liquid, and finally, taking out, cleaning and drying. The heparin-like modified coating loaded with carboxyl and sulfo groups is constructed on the surface of the hemodialysis membrane through the covalent reaction of amino, sulfydryl and catechol on polyphenol and the self-polymerization deposition adhesion effect of polyphenol, so that the hydrophilicity, the blood compatibility and the pollution resistance of the membrane material are remarkably improved.

Description

technical field [0001] The invention relates to the technical field of hemodialysis membranes and medical materials, in particular to a polyethersulfone hemodialysis membrane with a heparin-like modified coating and its preparation method and application. Background technique [0002] Chronic kidney disease (CKD) is a clinical syndrome with high morbidity and mortality, and it is also a serious disease causing kidney damage and dysfunction (U. Eduok, A. Abdelrasoul, A. Shoker, H. Doan, Recent developments, current challenges and future perspectives on cellulosichemodialysis membranes for highly efficient clearance of uremic toxins, Mater. Today Commun. 27(2021) 102183). End-stage renal disease is characterized by severe illness, high medical expenses, and difficulty in recovery. Once onset, renal function can drop below 10% of normal value (R.J.Glassock, C.Winearls, The global burden of chronic kidney disease: How valid are the estimates ?, Nephron-Clin. Pract. 110 (2008) 3...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D67/00B01D69/02B01D71/34B01D71/42B01D71/68A61M1/16
CPCB01D67/0002B01D67/0006B01D71/68B01D71/34B01D71/42B01D69/02A61M1/16
Inventor 吴力立张泽真董凌枫肖子煜张超灿
Owner WUHAN UNIV OF TECH