Unlock instant, AI-driven research and patent intelligence for your innovation.

Capsule coating of NMN and preparation method and application of NMN capsule

A coating and capsule technology, used in capsule delivery, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problem of decomposition into other substances, unstable chemical properties of NMN, and little practical effect, etc. problems, to achieve the effect of improving utilization and long-term efficacy

Active Publication Date: 2021-11-12
SHANDONG RUNDE BIOTECH CO LTD
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical properties of NMN are unstable, and it is easily oxidized and decomposed into other substances after being affected by light and oxygen. In addition, NMN is also easily decomposed in gastric juice, resulting in low utilization of NMN by oral administration , little practical effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Capsule coating of NMN and preparation method and application of NMN capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method for NMN capsules, comprising the steps of:

[0025] (1) By weight, 5 parts of shellac, 1 part of hydroxypropyl methylcellulose, 0.5 part of magnesium stearate, 3 parts of sorbitol, 1 part of titanium dioxide, and 45 parts of ethanol are mixed and stirred evenly to obtain Inner layer coating liquid, set aside.

[0026] (2) In parts by weight, 8 parts of sodium alginate, 0.5 parts of sodium carboxymethyl cellulose, 0.7 parts of fatty acid glycerides, 0.5 parts of magnesium stearate, 1.2 parts of polyvinyl acetate, 4 parts of glycerin, phthalate Mix 0.5 parts of dimethyl formate, 1 part of bone powder and 45 parts of water, and then stir evenly to obtain an outer layer coating liquid, which is set aside.

[0027] (3) Mix NMN, granulating agent (glycerol monolaurate and soybean lecithin at a mass ratio of 1.2:1), water at a mass ratio of 4:2:5, stir evenly, and then place in a granulator Medium granulation to obtain NMN granules.

[0028] (4) Spray t...

Embodiment 2

[0030] A preparation method for NMN capsules, comprising the steps of:

[0031] (1) By weight, 3 parts of shellac, 0.5 part of hydroxypropyl methylcellulose, 0.3 part of magnesium stearate, 2 parts of sorbitol, 0.8 part of titanium dioxide, and 30 parts of ethanol are mixed and stirred evenly to obtain Inner layer coating liquid, set aside.

[0032] (2) In parts by weight, 6 parts of sodium alginate, 0.3 parts of sodium carboxymethyl cellulose, 0.4 parts of fatty acid glycerides, 0.1 parts of magnesium stearate, 0.8 parts of polyvinyl acetate, 1 part of glycerin, phthalate Mix 0.6 parts of dimethyl formate, 0.5 parts of bone powder and 30 parts of water, and then stir evenly to obtain an outer layer coating solution, which is set aside.

[0033] (3) Mix NMN, granulating agent (glycerol monooleate and egg yolk lecithin at a mass ratio of 1.3:1), water at a mass ratio of 3.5:1.5:4, stir evenly, and then place in granulation Granulate in the machine to obtain NMN granules.

[...

Embodiment 3

[0036] A preparation method for NMN capsules, comprising the steps of:

[0037] (1) By weight, 6 parts of shellac, 1.2 parts of hydroxypropyl methylcellulose, 1.2 parts of magnesium stearate, 1 part of sorbitol, 0.6 part of titanium dioxide, and 45 parts of ethanol are mixed and stirred evenly to obtain Inner layer coating liquid, set aside.

[0038] (2) In parts by weight, 9 parts of sodium alginate, 0.5 parts of sodium carboxymethyl cellulose, 0.5 parts of fatty acid glycerides, 0.6 parts of magnesium stearate, 1.2 parts of polyvinyl acetate, 6 parts of glycerin, phthalate 1 part of dimethyl formate, 1 part of bone powder and 45 parts of water are mixed and stirred evenly to obtain an outer layer coating liquid, which is set aside.

[0039] (3) Mix NMN, granulating agent (glyceryl monostearate and egg yolk lecithin at a mass ratio of 1.3:1), water at a mass ratio of 3.5:2:4.5, stir evenly, and then place Granulate in a granulator to obtain NMN granules.

[0040] (4) Spray...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an NMN capsule coating and a preparation method and application of an NMN capsule. The coating is prepared from an inner coating and an outer coating, wherein the inner coating is prepared from the following components in parts by weight: 3 to 6 parts of shellac, 0.3 to 1.5 parts of hydroxypropyl methyl cellulose, 0.1 to 1.2 parts of magnesium stearate, 1 to 4 parts of sorbitol, 0.8 to 1.2 parts of titanium dioxide and 30 to 55 parts of ethanol; and the outer coating is prepared from the following components in parts by weight: 6 to 9 parts of sodium alginate, 0.3 to 0.8 part of sodium carboxymethyl cellulose, 0.4 to 0.7 part of fatty glyceride, 0.1 to 0.6 part of magnesium stearate, 0.8 to 2 parts of polyvinyl acetate, 1 to 8 parts of glycerol, 0.5 to 1 part of dimethyl phthalate, 0.5 to 1.5 parts of bone meal and 30 to 55 parts of water. The coating disclosed by the invention not only can prevent NMN from being influenced by light and oxygen, but also can enable NMN to smoothly pass through gastric juice without being disintegrated and to be disintegrated and absorbed after entering intestinal tracts, so that the utilization rate of NMN is increased.

Description

technical field [0001] The invention relates to the technical field of NMN preparation, in particular to a capsule coating of NMN and a preparation method and application of NMN capsules. Background technique [0002] The full name of NMN is β-nicotinamide mononucleotide, which is a derivative of nicotinic acid. Niacin is an essential vitamin for the human body. Niacin exists in the form of nicotinamide in the body, and it is converted into coenzyme 1 (NAD+) in the human body, which plays a role in many biological redox reactions. Activities are related to coenzyme 1, including energy metabolism, gene stability, nerve conduction, metabolism, etc. Studies have confirmed that the content of NAD+ decreases by 50% every 20 years with the increase of age. With the decrease of NAD+ content in the body, aging will also be accelerated, which triggers various symptoms of aging in the body. [0003] Oral NMN products can effectively supplement NMN in the human body. However, the ch...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/706A61K35/32A61K47/02A61K47/10A61K47/14A61K47/26A61K47/32A61K47/36A61K47/38A61P39/06A61P3/02
CPCA61K9/4816A61K9/4891A61K9/4833A61K31/706A61K47/36A61K47/38A61K47/26A61K47/32A61K47/14A61K47/10A61K47/02A61K35/32A61P39/06A61P3/02A61K2300/00
Inventor 卢健行李飞苏艺马善丽王芳赵鹏
Owner SHANDONG RUNDE BIOTECH CO LTD