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Cephalosporin compound and application thereof to preparation of medicine for treating diabetes and complications

Pending Publication Date: 2021-11-23
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is no prior art proof that cephalosporin antibiotics have the function of treating diabetes

Method used

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  • Cephalosporin compound and application thereof to preparation of medicine for treating diabetes and complications
  • Cephalosporin compound and application thereof to preparation of medicine for treating diabetes and complications
  • Cephalosporin compound and application thereof to preparation of medicine for treating diabetes and complications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1, the effect of cefotaxime sodium in treating diabetes in mice and its complications

[0095] 1. Animal feeding

[0096] Experimental animals: 8-week-old SPF grade C57BL / 6N male mice, weighing 18-22 g, never used any drugs before the experiment, from Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. The experimental animals were adaptively fed for one week in an environment with a temperature of 24-26°C and a 12h / 12h alternation of day and night. The animals were given food and water freely, and then grouped experiments were carried out.

[0097]2. Drugs and reagents:

[0098] The drugs used in the present invention include: Cefotaxime sodium; Metformin hydrochloride (Metformin); Streptozocin (STZ).

[0099] Preparation of reagents: (1) Citric acid buffer solution: add 2.1g citric acid to 100mL distilled water to prepare solution A, add 2.94g sodium citrate to 100mL distilled water to prepare solution B. Mix liquid A and liq...

Embodiment 2

[0146] Embodiment two, the effect of ceftriaxone sodium in treating diabetes in mice and its complications

[0147] 1. Animal feeding method is as shown in embodiment one:

[0148] 2. Drugs and reagents:

[0149] The drugs used in the present invention include: Ceftriaxone Sodium; Metformin hydrochloride (Metformin); Streptozocin (STZ).

[0150] Preparation of reagents: (1) Citric acid buffer solution: add 2.1g citric acid to 100mL distilled water to prepare solution A, add 2.94g sodium citrate to 100mL distilled water to prepare solution B. Mix liquid A and liquid B at a ratio of 1:1.32 or 1:1, adjust the pH to 4.2-4.5, and filter the mixed solution with a 2.22 μm filter.

[0151] ⑴ Ceftriaxone sodium solution (16mg / kg): prepared with physiological saline

[0152] ⑵Metformin hydrochloride solution (200mg / kg): prepared with normal saline

[0153] 3. Establishment of type 2 diabetes model in C57BL / 6N mice

[0154] Type 2 diabetes model group (Model): 56, after three weeks ...

Embodiment 3

[0167] Embodiment three, the effect of cefodizime sodium treatment mouse diabetes and its complications

[0168] 1. Animal feeding method is as shown in embodiment one:

[0169] 2. Drugs and reagents:

[0170] The drugs used in the present invention include: Cefodizime sodium; Metformin hydrochloride (Metformin); Streptozocin (STZ).

[0171] Preparation of reagents: (1) Citric acid buffer solution: add 2.1g citric acid to 100mL distilled water to prepare solution A, add 2.94g sodium citrate to 100mL distilled water to prepare solution B. Mix liquid A and liquid B at a ratio of 1:1.32 or 1:1, adjust the pH to 4.2-4.5, and filter the mixed solution with a 2.22 μm filter.

[0172] ⑴ Cefodizime sodium solution (16mg / kg): prepared with physiological saline

[0173] ⑵Metformin hydrochloride solution (200mg / kg): prepared with normal saline

[0174] 3. Establishment of type 2 diabetes model in C57BL / 6N mice

[0175] Type 2 diabetes model group (Model): 56, after three weeks of fe...

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Abstract

The invention relates to the technical field of medicines, in particular to a new application of a cephalosporin compound to preparation of a medicine for treating diabetes. The structural formula of the cephalosporin compound is shown in the formula I. Experimental results show that the cephalosporin compound can improve glycometabolism of a mouse with type 2 diabetes, improve insulin sensitivity and improve insulin resistance, and can reduce the blood sugar of the mouse with type 2 diabetes is reduced, and the curative effect of reducing the blood sugar by using the cephalosporin compound is 12.5 times that of metformin. The contents of urine protein, urine creatinine and urea nitrogen in the mouse with type 2 diabetes are reduced, so that the cephalosporin compound can protect the renal function of the mouse with diabetes and treat nephropathy caused by diabetes. The content of triglyceride, low-density lipoprotein cholesterol and total cholesterol in the mouse with type 2 diabetes is reduced, the blood fat level is adjusted, and the lipid metabolism of the mouse with diabetes is improved, so that the cephalosporin compound can be used for treating cardiovascular complications of diabetes. The cephalosporin compound can be clinically popularized and applied.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cephalosporin compound and its application in the preparation of medicines for treating diabetes and complications. Background technique [0002] Diabetes is a metabolic disease characterized by high blood sugar. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. Diabetes is a major disease that endangers human health. Diabetes can be divided into type 1 diabetes and type 2 diabetes. The International Diabetes Federation estimates that about 387 million people are currently diagnosed with diabetes, of which type 2 diabetes accounts for more than 90%. It is estimated that by 2035, the number of people with diabetes will reach 595 million. Type 2 diabetes is a type of diabetes due to relative insufficiency of insulin secretion and / or insulin resistance as the main etiology. Insulin relative insufficiency means that patients with typ...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61P3/10A61P27/02A61P9/10A61P15/00A61P17/02A61P9/14A61P1/02A61P9/00A61P3/06A61P13/12A23L33/00
CPCA61K31/546A61P3/10A61P27/02A61P9/10A61P15/00A61P17/02A61P9/14A61P1/02A61P9/00A61P3/06A61P13/12A23L33/00A23V2002/00
Inventor 陈新平李纯吴桐雨
Owner LANZHOU UNIVERSITY
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