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Method for oil drug loading and rapid emulsification in tumor treatment and integrated small equipment

A technology for tumor treatment and small equipment, applied in anti-tumor drugs, chemical instruments and methods, mixed methods, etc., can solve the problem that drug-loaded oil emulsion cannot be pre-scaled for mass production, antibody and protein drugs are easily inactivated at high temperature, and drugs are insoluble. and other problems, to achieve the effect of simple and easy preparation process and equipment operation, improve surgical safety, and meet environmental protection requirements.

Pending Publication Date: 2021-12-10
太阳雨林(厦门)生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] 1. Poor solubility of drugs, many targeted drugs are insoluble in water, such as apatinib or sorafenib;
[0016] 2. Heat sensitivity of drugs, most antibodies and protein drugs are easily inactivated at high temperature;
[0017] 3. The demand for individualized treatment of tumor patients makes it impossible to mass-produce drug-loaded oil emulsions in advance, and can only be produced according to the potential safety hazards of the treatment plan

Method used

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  • Method for oil drug loading and rapid emulsification in tumor treatment and integrated small equipment
  • Method for oil drug loading and rapid emulsification in tumor treatment and integrated small equipment
  • Method for oil drug loading and rapid emulsification in tumor treatment and integrated small equipment

Examples

Experimental program
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Effect test

Embodiment 1

[0063] Example 1 Oil-loaded drug and rapid emulsification process in tumor treatment

[0064] The composition of oil-loaded micro-nano liposome emulsion: including oil carrier, anti-tumor drug, contrast agent, emulsifier and water phase, wherein the volume ratio of oil carrier to water phase is 2:8-5:5, the amount of emulsifier It is 3%-15% of the emulsion; the variety and dosage of the contained antitumor drugs are determined according to the individualized treatment plan.

[0065] The emulsifier refers to Span-80, polyoxyethylene hydrogenated castor oil HCO-40, isopropyl myristate, lecithin, cholesterol, β-sitosterol, glyceryl monostearate, glyceryl caprylate , Tween-80, poloxamer-188 or a combination of several.

[0066] The water phase is physiological saline, or 5% glucose solution, or a pH regulator, or a water-soluble emulsifier solution, or a water-soluble contrast agent solution, or a combination of two or more thereof.

[0067] The pH regulator is a phosphate buffe...

Embodiment 2

[0102] Embodiment 2 loads chemotherapeutic drug vegetable oil_doxorubicin rapeseed oil

[0103] For specific operations, refer to steps 1, 2 and 3 of the process flow 1 in Example 1. 60 mg of doxorubicin hydrochloride and 15 ml of rapeseed oil were placed in a reaction kettle, the reaction temperature was 40° C., the pressure was 8 MPa, the ultrasonic power was 100 W, and the ultrasonic time was 15 minutes to prepare the doxorubicin-loaded rapeseed oil.

Embodiment 3

[0104] Example 3 Loading Chemotherapy Drug Fatty Acid_Raltitrexed Docosahexaenoic Acid

[0105] For specific operations, refer to steps 1, 2 and 3 of the process flow 1 in Example 1. 4mg of raltitrexed, 10ml of docosahexaenoic acid, and 0.5g of erucic acid were placed in a reaction kettle, the reaction temperature was 50°C, the pressure was 15MPa, the ultrasonic power was 300W, and the ultrasonic time was 60min. Dicosahexaenoic acid.

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Abstract

The invention relates to a method for oil drug loading and rapid emulsification in tumor treatment and integrated small equipment. The grease has the characteristics of targeting and depositing in tumor tissues for a long time, and also has the effect of treating tumors. Under the assistance of supercritical CO2 and ultrasound, an oil carrier is directly loaded with a drug and emulsified to form a stable nano-liposome emulsion, so that real targeted drug loading is realized, an unsafe oil carrier is changed into a safe liposome emulsion, and the oil carrier can be directly and safely injected into arteries, veins, lymph and tissues of the whole body. The method can also be used for preparing drug-loading oil, and emulsification is not needed; or liposomal emulsions of non-drug-loaded oil are prepared to meet different therapeutic regimens. The integrated equipment comprises a CO2 supply unit, a material supplementing unit, a preparation unit, a sterilization unit and a collector; and the equipment is small in size, convenient to transfer and convenient to use, tumor individualized treatment medicaments can be prepared on site in an operating room and a liquid preparation chamber according to different treatment schemes, and the treatment requirements of different tumor patients are met.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a method for oil loading and rapid emulsification in tumor treatment and integrated small equipment. Background technique [0002] Vegetable oil is a compound composed of higher fatty acids and glycerol. It is widely distributed in nature. It is the oil obtained from the fruits, seeds, and germs of plants. The main components are esters produced by straight-chain higher fatty acids and glycerol. In addition to palmitic acid, stearic acid and oleic acid, the fatty acids in vegetable oil also contain a variety of unsaturated acids, such as erucic acid, oleic acid, ricinoleic acid and so on. [0003] Animal oil can be divided into oils of terrestrial warm-blooded animals and poultry, such as tallow, suet, lard, etc., which are generally solid, and its main components are triglycerides of palmitic acid and stearic acid; marine mammals and fish Oils and fats, such as whale oil, fi...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/44A61K49/04A61K49/18A61P35/00B01F3/08B01F13/10B01J19/08B01J19/10
CPCB01J19/10B01J19/087A61K9/107A61K47/44A61K9/0019A61K49/0438A61P35/00A61K49/1806
Inventor 赵一麟周媛媛刘凤武周旭陈炜斌
Owner 太阳雨林(厦门)生物医药有限公司