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Anti-photosensitive vitamin K2 microcapsule preparation and preparation method thereof

A technology of vitamins and preparations, which is applied in food ingredients as antioxidants, food forming, dough processing, etc. It can solve the problems of limited vitamin loss protection, less involvement of vitamin loss, and difficulty in realizing it, achieving excellent brewability and , Excellent preparation stability, solve the effect of easy degradation

Pending Publication Date: 2021-12-24
INNOBIO CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above patents all disclose the preparation methods of vitamin microcapsules or powders. Some of these methods involve expensive equipment and are generally difficult to realize. At the same time, they are less involved in the loss of vitamins caused by environmental factors, especially vitamins caused by temperature and light. The loss protection is more limited

Method used

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  • Anti-photosensitive vitamin K2 microcapsule preparation and preparation method thereof
  • Anti-photosensitive vitamin K2 microcapsule preparation and preparation method thereof
  • Anti-photosensitive vitamin K2 microcapsule preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Under the condition of avoiding light and passing nitrogen, weigh 120g MCT in a 500ml beaker, keep the temperature at 42°C, add 3g vitamin E, disperse evenly, add 5g vitamin K2, stir until completely dispersed, and obtain an oil phase.

[0035] Weigh 900g of water into a 2000ml beaker, keep the temperature at 58°C, add 400g of sodium starch octenyl succinate, 478g of solid corn syrup and 5g of sodium ascorbate, stir and disperse evenly, cool the emulsion to 42°C, adjust the pH to 3.0 with acetic acid, An aqueous phase is obtained.

[0036]Weigh 250g of water into a 500ml beaker, control the temperature at 24°C, add 2.5g of xanthan gum to it, stir and disperse evenly, add 0.4g of titanium dioxide, 4.1g of benzophenone, and 12g of benzoin resin, stir and disperse evenly, and obtain photostable agent combination solution, the emulsion viscosity is 227mPa·s.

[0037] Put the oil phase into the water phase, stir and emulsify for 30 minutes, disperse at high speed for 12 min...

Embodiment 2

[0040] Under the condition of avoiding light and passing nitrogen, weigh 35g soybean oil into a 250ml beaker, keep the temperature at 44°C, add 2g BHT, disperse evenly, add 1.5g vitamin K2, stir until completely dispersed, and obtain an oil phase.

[0041] Weigh 200g of water into a 1000ml beaker, keep the temperature at 60°C, add 63g of sodium starch octenyl succinate, 64g of solid corn syrup and 3g of ascorbic acid, stir and disperse evenly, cool the emulsion to 44°C, adjust the pH to 3.2 with citric acid, An aqueous phase is obtained.

[0042] Weigh 40g of water into a 250ml beaker, control the temperature at 22°C, add 0.4g of hydroxypropylmethylcellulose to it, stir and disperse evenly, add 0.08g of titanium dioxide, 1.2g of benzophenone, 3.7g of benzoin resin, stir and disperse evenly , to obtain light stabilizer combination solution, the emulsion viscosity is 206mPa·s.

[0043] Put the oil phase into the water phase, stir and emulsify for 33 minutes, disperse at high sp...

Embodiment 3

[0046] Under the condition of avoiding light and passing nitrogen, weigh 500g of olive oil in a 1000ml beaker, keep the temperature at 43°C, add 40g of rosemary extract, disperse evenly, add 20g of vitamin K2, stir until completely dispersed, and obtain an oil phase.

[0047] Weigh 4500g water into a 1000ml beaker, keep the temperature at 60°C, add 1640g sodium starch octenyl succinate, 1840g maltoligosaccharide and 62g sodium ascorbate, stir and disperse evenly, cool the emulsion to 43°C, adjust the pH to 3.1 with malic acid , to obtain the aqueous phase.

[0048] Weigh 460g of water into a 2500ml beaker, control the temperature at 26°C, add 4.6g of methylcellulose to it, stir and disperse evenly, add 1.1g of titanium dioxide, 12g of benzophenone, and 43g of benzoin resin, stir and disperse evenly, and obtain light stable agent combination solution, the viscosity of the emulsion is 174mPa·s.

[0049] Put the oil phase into the water phase, stir and emulsify for 35 minutes, d...

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Abstract

The invention discloses an anti-photosensitive vitamin K2 microcapsule preparation and a preparation method thereof. By adopting a light stabilizer combination with specific composition to be matched with a microencapsulation means, the sensitivity of vitamin K2 to light can be effectively reduced, an extremely strong anti-photosensitive effect is achieved, and besides, the anti-photosensitive vitamin K2 micro-capsule preparation has very good stability. 24-hour illumination retention rate of the obtained vitamin K2 product can reach 98% or above and far exceeds the illumination retention rate namely 18% of raw materials, besides, the three-month accelerated retention rate of the product exceeds 96%, and the stability is excellent. The product is simple in preparation process, has excellent reconstituability and preparation stability, and can be applied to various terminal environments. According to the invention, the problem that the vitamin K2 is unstable and especially easy to degrade in a light environment is solved, and the product can be widely applied to baking, solid beverages, beverages, capsules, tablets and the like.

Description

technical field [0001] The invention belongs to the technical field of microcapsules, and in particular relates to an anti-photosensitive vitamin K2 microcapsule preparation and a preparation method thereof. Background technique [0002] Vitamin K is a class of compounds with a benzoquinone structure, including fat-soluble vitamins K1 and K2 and water-soluble vitamins K3 and K4, among which the most important one is vitamin K2 with high activity and medicinal value. The most important physiological function of vitamin K is to maintain bone health, promote bone development, prevent and treat osteoporosis. The role of vitamin K2 is to activate the osteocalcin (Gla) in the matrix, mainly vitamin K-dependent protein (BGP). Under the action of vitamin K2, after the matrix osteocalcin is activated, many calcium binding sites are formed on the protein , this activated calcium-binding site is able to follow into the bone and bind calcium. Therefore, vitamin K2 has special signific...

Claims

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Application Information

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IPC IPC(8): A23L33/15A23L2/39A23L2/52A23P10/30A21D2/14A21D13/06
CPCA23L33/15A23L2/39A23L2/52A23P10/30A21D2/14A21D13/06A23V2002/00A23V2200/30A23V2250/022A23V2250/5086A23V2250/712A23V2250/7144A23V2300/26A23V2300/10A23V2250/708A23V2250/51088A23V2250/032A23V2200/02A23V2250/044A23V2250/21A23V2250/28Y02A40/90
Inventor 徐玉涛任翔田中乐范超陈剑彬吴文忠
Owner INNOBIO CORP LTD
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