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A repairing dressing containing ginseng extract and its preparation method

A technology of ginseng extraction and plant extracts, applied in bandages, medical science and other directions, can solve the problems of physical doping, inability to guarantee antibacterial properties, easy falling off, etc., and achieve high practicability, excellent water retention and moisturizing properties, and reasonable process design. Effect

Active Publication Date: 2022-06-28
蓝科医美科学技术(吉林)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the deepening of the research, we found that in order to improve the antibacterial performance of the gel dressing, antibacterial particles are generally added to the gel in the prior art, but the pure physical doping is used to cover it with the gel. Easy to fall off, the actual antibacterial performance cannot be guaranteed

Method used

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  • A repairing dressing containing ginseng extract and its preparation method

Examples

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Comparison scheme
Effect test

Embodiment 1

[0038] A preparation method of a repair dressing containing ginseng extract, comprising the following steps:

[0039] (1) Take starch, add 2 mL of sodium hydroxide, stir and mix for 20 min, alkalize at -18°C for 20 h, stand to thaw, then transfer to 50 mL of ethanol solution, stir and disperse for 1 h, add tris and benzyl ammonium chloride (catalyst) ), continue to stir for 10min, add 2-chloroethylamine hydrochloride, stir and react for 18h, filter and collect the product, wash, freeze-dry to obtain modified starch; the mass ratio of starch to 2-chloroethylamine hydrochloride is 1:2 .

[0040] (2) Take chitosan and acetic acid solution, mix and stir to obtain a mixed solution, the mass concentration of the mixed solution is 2.5%, spray the mixed solution into the sodium polyphosphate solution, react for 4 hours, take the precipitated beads, and transfer to sodium hydroxide Swell in the solution, add epichlorohydrin solution, continue the reaction for 24h, wash until neutral, ...

Embodiment 2

[0051] A preparation method of a repair dressing containing ginseng extract, comprising the following steps:

[0052] (1) Take starch, add 2 mL of sodium hydroxide, stir and mix for 25 min, alkalize at -18°C for 21 h, stand to thaw, then transfer to 50 mL of ethanol solution, stir and disperse for 1.2 h, add tris and benzyl ammonium chloride ( catalyst), continue stirring for 15min, add 2-chloroethylamine hydrochloride, stir and react for 19h, filter and collect the product, wash, freeze-dry to obtain modified starch; the mass ratio of starch to 2-chloroethylamine hydrochloride is 1: 2.

[0053] (2) Take chitosan and acetic acid solution, mix and stir to obtain a mixed solution, the mass concentration of the mixed solution is 2.5%, spray the mixed solution into the sodium polyphosphate solution, react for 4.5h, take the precipitated beads, and transfer them to hydroxide Swell in sodium solution, add epichlorohydrin solution, continue to react for 25h, wash until neutral, free...

Embodiment 3

[0064] A preparation method of a repair dressing containing ginseng extract, comprising the following steps:

[0065] (1) Take starch, add 2 mL of sodium hydroxide, stir and mix for 30 min, alkalize at -18°C for 22 h, stand to thaw, then transfer to 50 mL of ethanol solution, stir and disperse for 1.5 h, add tris and benzyl ammonium chloride ( catalyst), continue stirring for 20min, add 2-chloroethylamine hydrochloride, stir and react for 20h, filter and collect the product, wash, freeze-dry to obtain modified starch; the mass ratio of starch to 2-chloroethylamine hydrochloride is 1: 2.

[0066] (2) Take chitosan and acetic acid solution, mix and stir to obtain a mixed solution, the mass concentration of the mixed solution is 2.5%, spray the mixed solution into the sodium polyphosphate solution, react for 4.5h, take the precipitated beads, and transfer them to hydroxide Swell in sodium solution, add epichlorohydrin solution, continue to react for 26h, wash until neutral, free...

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Abstract

The invention discloses a repairing dressing containing ginseng extract and a preparation method thereof, wherein the main components are functionalized chitosan, oxidized sodium alginate, chitosan microspheres, plant extracts and other components to prepare A repair dressing containing ginseng extract with excellent antibacterial properties was obtained; a hydrogel was prepared with functionalized chitosan and oxidized sodium alginate as the main components, and the whole hydrogel presented a porous network, which was beneficial to The slow release effect of chitosan microspheres and plant extracts; the application introduces plant extracts, which are ginseng extracts and centella asiatica extracts, which can facilitate skin absorption on the one hand, and plant extracts also It has anti-inflammatory and antibacterial effects, improves the antibacterial properties of repair dressings, and avoids wound inflammation. The process design of the invention is reasonable, and the prepared repair dressing not only has excellent antibacterial performance, but also has excellent water retention and moisturizing performance, and can effectively promote wound repair.

Description

technical field [0001] The invention relates to the technical field of dressings, in particular to a repair dressing containing ginseng extract and a preparation method thereof. Background technique [0002] Hydrogel dressing is one of the more common dressings on the market. It is generally suitable for the repair of epidermal defect wounds, painful wounds and other wounds. When used, hydrogel dressings can provide a moist environment for the wound to promote wound healing. At the same time, it can absorb wound exudate and relieve wound pain. [0003] With the deepening of research, we found that in order to improve the antibacterial properties of gel dressings, antibacterial particles are generally added to the gel in the prior art. It is easy to fall off, and the actual antibacterial performance cannot be guaranteed. [0004] Based on the above situation, we disclose a repair dressing containing ginseng extract and a preparation method thereof, which have solved the tec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08B31/12
CPCA61L26/008A61L26/0085A61L26/0057A61L26/0023A61L26/0033A61L26/0066C08B31/125A61L2300/602A61L2300/45A61L2300/41A61L2300/404A61L2300/412A61L2300/252A61L2300/30C08L5/04C08L5/08C08L3/02
Inventor 曹原眭春徐阳
Owner 蓝科医美科学技术(吉林)有限公司
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